Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2017

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Guidelines for family-centered care in neuro-ICU populations: caveats for routine palliative care., Michel T Torbey, Gretchen M Brophy, Panayiotis N Varelas, Julian Bösel, Edward Manno, Mary Kay Bader, Jose I Suarez, David Seder, and W David Freeman

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In vitro evaluation of the Fresenius Kabi CATSmart Autotransfusion System., Melissa Alberts, Robert C Groom, Richard Walczak, Robert Kramer, Adrienne Karpiel, Jeanette Dieter, Lisa Sheth, Nathaniel H Greene, and Edmund H Jooste

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Is it time for entrustable professional activities for residency program directors?, Robert G Bing-You, Eric Holmboe, Kalli Varaklis, and Jo Linder

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Is it time for goal-directed therapy in perfusion?, Robert C Groom

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Management of a patient requiring intrathecal drain insertion and removal in the setting of concomitant dual antiplatelet therapy with clopidogrel and aspirin: a case report., Christopher W Connors and Janie D Nguyen

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Mechanical chest compressions improve rate of return of spontaneous circulation and allow for initiation of percutaneous circulatory support during cardiac arrest in the cardiac catheterization laboratory., Joseph M Venturini, Elizabeth Retzer, J Raider Estrada, Janet Friant, David Beiser, Dana Edelson, Jonathan Paul, John Blair, Sandeep Nathan, and Atman P Shah

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MicroRNA transfer between bone marrow adipose and multiple myeloma cells., Luna Soley, Carolyne Falank, and Michaela R Reagan

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National Breast Reconstruction Utilization in the Setting of Postmastectomy Radiotherapy., Shantanu N Razdan, Peter G Cordeiro, Claudia R Albornoz, Joseph J Disa, Hina J Panchal, Alice Y Ho, Adeyiza O Momoh, and Evan Matros

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Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration., Pan Li, Aldona A Karaczyn, Rose McGlauflin, Amanda J Favreau-Lessard, Edward Jachimowicz, Calvin P Vary, Kailin Xu, Don M Wojchowski, and Pradeep Sathyanarayana

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Point-of-care ultrasound use, accuracy, and impact on clinical decision making in Rwanda hospitals., Patricia C Henwood, David C Mackenzie, Andrew S Liteplo, Joshua S Rempell, Alice F Murray, Megan M Leo, Damas Dukundane, Anthony J Dean, Stephen Rulisa, and Vicki E Noble

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Recent advances in the field of ovarian tissue cryopreservation and opportunities for research., Camille Ladanyi, Amir Mor, Mindy S Christianson, Namisha Dhillon, and James H Segars

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Stroke: a road map for subacute management., Jane G Morris, Emily Carter MD, and Stephen A Martin

Stroke: A road map for subacute management: Time is of the essence when a patient has signs and symptoms suggestive of a stroke or TIA. What should your initial approach and diagnostic work-up be?, Jane G. Morris, Emily L. Carter, and Stephen A. Martin

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Technology-enhanced focus groups as a component of instrument development., Tania D. Strout and Rachel L. DeFazio

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The need for optimized crystalloid-based resuscitation., Avi Yitzhak, Yuval Glick, Avi Benov, Roy Nadler, Joseph F Rappold, and Elon Glassberg

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Cardiac outcomes after ischemic stroke or transient ischemic attack: effects of pioglitazone in patients with insulin resistance without diabetes mellitus., Lawrence H Young, Catherine M Viscoli, Jeptha P Curtis, Silvio E Inzucchi, Gregory G Schwartz, Anne M Lovejoy, Karen L Furie, Mark J Gorman, Robin Conwit, J Dawn Abbott, Daniel L Jacoby, Daniel M Kolansky, Steven E Pfau, Frederick S Ling, and Walter N Kernan

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Adipose, bone, and myeloma: contributions from the microenvironment., Michelle M McDonald, Heather Fairfield, Carolyne Falank, and Michaela R. Reagan

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Adolescent female with abdominal pain., Diane Walsh, Rebecca B Bloch, and Tania D Strout

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Alcohol Flush and Flex Protocol (Affp) to Decrease the Risk of Residual Bacterial Colonization Prior to Eus or Duodenoscope Insertion: Report of Use in 2915 Cases...Digestive Disease Week (DDW) 2017 American Society for Gastrointestinal Endoscopy (ASGE) Program and Abstracts, Chicago, Illinois, 6–9 May 2017., Tian Gao, Matthew Warndorf, David A. Klibansky, Daniil Rolshud, Andreas Stefan, August J. Valenti, and Douglas A. Howell

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An evaluation of the opportunities for collaborative practice occurring in and the impact of interprofessional education on advanced pharmacy practice experiences., Elena M Umland, Jonathan Valenzano, Caitlin Brown, and Carolyn Giordano

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Elevated intra-articular cobalt and chromium levels in mechanically assisted crevice corrosion in metal-on-polyethylene total hip arthroplasty., Brian J McGrory, Abigail M Payson, and Johanna A MacKenzie

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ERBB signaling attenuates proinflammatory activation of nonclassical monocytes., Sergey Ryzhov, Anton Matafonov, Cristi L Galindo, Qinkun Zhang, Truc-Linh Tran, Daniel J Lenihan, Carrie Geisberg Lenneman, Igor Feoktistov, and Douglas B Sawyer

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Expression and function of ABCG2 and XIAP in glioblastomas., Ivette F Emery, Archana Gopalan, Stephanie Wood, Kin-Hoe Chow, Chiara Battelli, Joshy George, Hagen Blaszyk, Jeffrey Florman, and Kyuson Yun

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Fat and bone: where are we now?, Paul Dimitri and Cliff Rosen

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Governing roles for Trib3 pseudokinase during stress erythropoiesis., Arvind Dev, Ruth Asch, Edward Jachimowicz, Nicole Rainville, Ashley Johnson, Emily Greenfest-Allen, and Don M Wojchowski

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Higher Doses of Fish Oil-Based Lipid Emulsions Used to Treat Inadequate Weight Gain and Rising Triene:Tetraene Ratio in a Severely Malnourished Infant With Intestinal Failure-Associated Liver Disease., Mary Riedy, Brittany DePaula, Mark Puder, Kathleen M Gura, and Kevin A Sztam

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(Re)Building a Kidney., Leif Oxburgh, Thomas J Carroll, Ondine Cleaver, Daniel R Gossett, Deborah K Hoshizaki, Jeffrey A Hubbell, Benjamin D Humphreys, Sanjay Jain, Jan Jensen, David L Kaplan, Carl Kesselman, Christian J Ketchum, Melissa H Little, Andrew P McMahon, Stuart J Shankland, Jason R Spence, M Todd Valerius, Jason A Wertheim, Oliver Wessely, Ying Zheng, and Iain A Drummond

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Sa1389 Ercp Placed Short Biliary Self-Expanding Metal Stents (SSEMS) and Neoadjuvant Therapy of Borderline Pancreatic Cancer in 100 Patients...Digestive Disease Week (DDW) 2017 American Society for Gastrointestinal Endoscopy (ASGE) Program and Abstracts, Chicago, Illinois, 6–9 May 2017., John Walker, Tian Gao, Andreas Stefan, Daniil Rolshud, David A. Klibansky, Douglas A. Howell, Gina Z. Blaszyk, and Lisa A. Rutstein

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Seasonal Patterns in Eastern Equine Encephalitis Virus Antibody in Songbirds in Southern Maine., Susan P Elias, Patrick Keenan, Joan L Kenney, Sara R Morris, Kristen M Covino, Sara Robinson, Kimberly A Foss, Peter W Rand, Charles Lubelczyk, Eleanor H Lacombe, John-Paul Mutebi, David Evers, and Robert P Smith

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Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep., Brian J Piper, Rebecca M DeKeuster, Monica L Beals, Catherine M Cobb, Corey A Burchman, Leah Perkinson, Shayne T Lynn, Stephanie D Nichols, and Alexander T Abess

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The central nervous system and bone metabolism: an evolving story., Paul Dimitri and Cliff Rosen

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Tolerance of uncertainty: conceptual analysis, integrative model, and implications for healthcare., Marij A Hillen, Caitlin M Gutheil, Tania D Strout, Ellen M A Smets, and Paul K J Han

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Unusual Lesion of the Bile Duct Diagnosed With Digital Cholangioscopy and Biopsy...Digestive Disease Week (DDW) 2017 American Society for Gastrointestinal Endoscopy (ASGE) Program and Abstracts, Chicago, Illinois, 6–9 May 2017, Tian Gao, Douglas A. Howell, and Daniil Rolshud

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Woman with severe headache., Randy M Kring and David C Mackenzie

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A systematic review of transition studies of pulmonary arterial hypertension specific medications., Avraham Sofer, Michael J Ryan, Ryan J Tedford, Joel A Wirth, and Wassim H Fares

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Cardio-Oncology-a rapidly evolving and expanding field of medicine., Daniel J Lenihan and Douglas B Sawyer

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Cardio-oncology: the role of big data., Anant Mandawat, Andrew E Williams, and Sanjeev A Francis

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“Choosing Wisely” Imaging Recommendations: Initial Implementation in New England Emergency Departments., Ali S. Raja

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"Choosing Wisely" imaging recommendations: initial implementation in New England emergency departments., Ali S Raja, Arjun K Venkatesh, Nathan Mick, Cristopher P Zabbo, Kohei Hasegawa, Janice A Espinola, Jane C Bittner, and Carlos A Camargo

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Determinants of follow-up failure in patients undergoing vascular surgery procedures., Dejah R Judelson, Jessica P Simons, Julie M Flahive, Virendra I Patel, Christopher T Healey, Brian W Nolan, Daniel J Bertges, and Andres Schanzer

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Disclosing the uncertainty associated with prognostic estimates in breast cancer., Ellen G Engelhardt, Arwen H Pieterse, Paul K J Han, Nanny van Duijn-Bakker, Frans Cluitmans, Ed Maartense, Monique M E M Bos, Nir I Weijl, Cornelis J A Punt, Patricia Quarles van Ufford-Mannesse, Harm Sleeboom, Johanneke E A Portielje, Koos J M van der Hoeven, F J Sherida Woei-A-Jin, Judith R Kroep, Hanneke C J M de Haes, Ellen M A Smets, and Anne M Stiggelbout

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Emergency Medicine Faculty Are Poor at Predicting Burnout in Individual Trainees: An Exploratory Study., Dave W Lu, Patrick M Lank, and Jeremy B Branzetti

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Factors associated with deciding between risk-reducing salpingo-oophorectomy and ovarian cancer screening among high-risk women enrolled in GOG-0199: an NRG Oncology/Gynecologic Oncology Group study., Phuong L Mai, Marion Piedmonte, Paul K Han, Richard P Moser, Joan L Walker, Gustavo Rodriguez, John Boggess, Thomas J Rutherford, Oliver Zivanovic, David E Cohn, J Tate Thigpen, Robert M Wenham, Michael L Friedlander, Chad A Hamilton, Jamie Bakkum-Gamez, Alexander B Olawaiye, Martee L Hensley, Mark H Greene, Helen Q Huang, and Lari Wenzel

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IGFBP-4 regulates adult skeletal growth in a sex-specific manner., David E Maridas, Victoria E DeMambro, Phuong T Le, Kenichi Nagano, Roland Baron, Subburaman Mohan, and Clifford J Rosen

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Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1., Yong-Ri Jin, J Patrizia Stohn, Qiaozeng Wang, Kenichi Nagano, Roland Baron, Mary L Bouxsein, Clifford J Rosen, Vyacheslav A Adarichev, and Volkhard Lindner

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Personal Digital Assistant-Based Self-Work Sampling Study of Pediatric Interns Quantifies Workday and Educational Value., Joyce K Campbell, Michael V Ortiz, Mary C Ottolini, Sarah Birch, and Dewesh Agrawal

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Public perceptions of expert disagreement: Bias and incompetence or a complex and random world?, Nathan F Dieckmann, Branden B Johnson, Robin Gregory, Marcus Mayorga, Paul K J Han, and Paul Slovic

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Survey of neonatal intensive care unit nurse attitudes toward therapeutic hypothermia treatment., Alexa Craig, Christine James, Janelle Bainter, Francis L Lucas, Scott Evans, and John Glazer

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Tacrolimus interaction with nafcillin resulting in significant decreases in tacrolimus concentrations: a case report., Minkey Wungwattana and Marizela Savic

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Therapeutic options to treat pediatric obesity., Allen F Browne

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Usefulness of a noninvasive device to identify elevated left ventricular filling pressure using finger photoplethysmography during a Valsalva maneuver., Panagis Galiatsatos, Theingi Tiffany Win, Jennifer Monti, Peter V Johnston, William Herzog, Jeffrey C Trost, Chao-Wei Hwang, Gene Y Fridman, Nae-Yuh Wang, and Harry A Silber

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Valproate protein binding is highly variable in ICU patients and not predicted by total serum concentrations: a case series and literature review., Richard R Riker, David J Gagnon, Colman Hatton, Teresa May, David B Seder, Katie Stokem, and Gilles L Fraser

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The airway in inhalational injury: diagnosis and management., A Sabri, H Dabbous, A Dowli, and R Barazi

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Parathyroid hormone directs bone marrow mesenchymal cell fate., Yi Fan, Jun-Ichi Hanai, Phuong T Le, Ruiye Bi, David Maridas, Victoria DeMambro, Carolina A Figueroa, Serkan Kir, Xuedong Zhou, Michael Mannstadt, Roland Baron, Roderick T Bronson, Mark C Horowitz, Joy Y Wu, John P Bilezikian, David W Dempster, Clifford J Rosen, and Beate Lanske

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Bone-fat interaction., Elizabeth Rendina-Ruedy and Clifford J Rosen

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Effect of adjunct femoral endarterectomy in lower extremity bypass on perioperative and 1-year outcomes., Peter A Soden; Sara L Zettervall; Katie E Shean; Sarah E. Deery MD, MPH; Jeffrey A Kalish; Christopher T. Healey; Nikhil Kansal; Marc L Schermerhorn; and Vascular Study Group of New England (VSGNE)

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Harms of cervical cancer screening in the United States and the Netherlands., Dik Habbema, Sheila Weinmann, Marc Arbyn, Aruna Kamineni, Andrew E Williams, Inge M C M de Kok, Folkert van Kemenade, Terry S Field, Joost van Rosmalen, and Martin L Brown

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Increased utilization of cervical disk arthroplasty in university hospitals with regional variation and socioeconomic discrepancies., Sheri K Palejwala, Anand I Rughani, and Travis M Dumont

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Pioglitazone and risk for bone fracture: safety data from a randomized clinical trial., Catherine M Viscoli, Silvio E Inzucchi, Lawrence H Young, Karl L Insogna, Robin Conwit, Karen L Furie, Mark Gorman, Michael A Kelly, Anne M Lovejoy, and Walter N Kernan

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Project IMPACT pilot report: feasibility of implementing a hospital-to-home transition bundle., Leah A Mallory, Snezana Nena Osorio, B Stephen Prato, Jennifer DiPace, Lisa Schmutter, Paula Soung, Amanda Rogers, William J Woodall, Kayla Burley, Sandra Gage, and David Cooperberg

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Real-time H2 O2 measurements in bone marrow mesenchymal stem cells (MSCs) show increased antioxidant capacity in cells from osteoporotic women., Flavia Román, Carla Urra, Omar Porras, Ana María Pino, Clifford J. Rosen, and Juan Pablo Rodríguez

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Spontaneous elbow hemarthrosis identified by point-of-care ultrasound., David C Mackenzie and Scott McCorvey

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The development of an international standard set of outcomes measures for evaluating the treatment of overactive bladder., S J. Pulliam, C E. Foust-Wright, and A Morse

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Ultrasound gel minimizes third body debris with partial hardware removal in joint arthroplasty., Aidan C McGrory, Lee Replogle, and Donald Endrizzi

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Patient-reported outcome metrics in total joint arthroplasty., Adam Rana and Shaleen Vira

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Social Contexts in Medicine: A Patient-Centered Curriculum Empowering Medical Students to Provide Contextualized Care., Carolyn Drake, Melissa Keeport, Alice Chapman, and Chayan Chakraborti

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Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction., Tom J Parry, Anindita Ganguly, Erika L Troy, J Luis Guerrero, Jennifer F Iaci, Maya Srinivas, Andrea M Vecchione, Donald C Button, Craig S Hackett, Ronald Zolty, Douglas B Sawyer, and Anthony O Caggiano

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Cancer incidence in patients with hereditary hemorrhagic telangiectasia., Christine W. Duarte, Adam W. Black, F Lee Lucas, and Calvin P H Vary

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Cervical spine MRI in patients with negative CT: a prospective, multicenter study of the Research Consortium of New England Centers for Trauma (ReCONECT)., Adrian A Maung, Dirk C Johnson, Kimberly Barre, Thomas Peponis, Tomaz Mesar, George C Velmahos, Daniel McGrail, George Kasotakis, Ronald I Gross, Michael S Rosenblatt, Kristen C Sihler, Robert J Winchell, Walter Cholewczynski, Kathryn L Butler, Stephen R Odom, and Kimberly A Davis

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Diagnosis of Severe Acute Lower Gastrointestinal Bleeding With CTA., Samantha L. Wood, Louis Eubank, and Tania D. Strout

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Factor analysis of the scale of prodromal symptoms: data from the early detection and intervention for the prevention of psychosis program., Ivy F Tso, Stephan F Taylor, Tyler B Grove, Tara Niendam, Steven Adelsheim, Andrea Auther, Barbara Cornblatt, Cameron S Carter, Roderick Calkins, J Daniel Ragland, Tamara Sale, and William R McFarlane

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Human NUMB6 induces epithelial-mesenchymal transition and enhances breast cancer cells migration and Invasion., Aldona A. Karaczyn, Tamara L Adams, Robert Y S Cheng, Nicholas N Matluk, and Joseph M Verdi

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ICU clinicians underestimate breathing discomfort in ventilated subjects., Andrew P Binks, Steven Desjardin, and Richard Riker

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Intensity in End-of-Life Care for Medicare Patients Dying with Melanoma (S741)., Rebecca Hutchinson, Lee Lucas, and Kathleen Fairfield

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Mechanisms of marrow adiposity and its implications for skeletal health., Annegreet G Veldhuis-Vlug and Clifford J Rosen

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Minor papilla endotherapy in patients with ventral duct obstruction: identification and management., Nicholas G Brown, Douglas A. Howell, Brian C Brauer, John Walker, Sachin Wani, and Raj J Shah

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One-year pivotal trial outcomes of the Nellix system for endovascular aneurysm sealing., Jeffrey P Carpenter, Robert Cuff, Clifford Buckley, Christopher Healey, Sajjad Hussain, Michel M P J Reijnen, Jose Trani, and Dittmar Böckler

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Reducing Acute Kidney Injury Due to Contrast Material: How Nurses Can Improve Patient Safety., Peggy Lambert, Kristine Chaisson, Susan Horton, Carmen Petrin, Emily Marshall, Sue Bowden, Lynn Scott, Sheila Conley, Janette Stender, Gertrude Kent, Ellen Hopkins, Brian Smith, Anita Nicholson, Nancy Roy, Brenda Homsted, Cindy Downs, Cathy S Ross, Jeremiah Brown, and Northern New England Cardiovascular Disease Study Group

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Social Media in Nurse Anesthesia: A Model of a Reproducible Educational Podcast., Kristin Andrejco, Jon Lowrance, Brad Morgan, Cassidy Padgett, and Shawn Collins

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The effect of anticoagulation on bleeding-related complications following ureteroscopy., Mary E Westerman, Joseph A Scales, Vidit Sharma, Derek J Gearman, Johann P Ingimarsson, and Amy E Krambeck

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Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity., Zhaofei Wu, M Elena Martinez, Donald L St Germain, and Arturo Hernandez

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Valproate for agitation in critically ill patients: a retrospective study., David J. Gagnon, Gabriel V Fontaine, Kathryn E. Smith, Richard R. Riker, Russell R Miller, Patricia A. Lerwick, F L. Lucas, John T. Dziodzio, Kristen C. Sihler, and Gilles L. Fraser

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Vitamin D intake and the risk of incident kidney stones., Pietro Manuel Ferraro, Eric N. Taylor, Giovanni Gambaro, and Gary C Curhan

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Integrating GWAS and co-expression network data identifies bone mineral density genes SPTBN1 and MARK3 and an osteoblast functional module., Gina M Calabrese, Larry D Mesner, Joseph P Stains, Steven M Tommasini, Mark C Horowitz, Clifford J Rosen, and Charles R Farber

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Dyslipidemia: Current Therapies And Guidelines For Treatment, Edward T. Carreras and Donna M. Polk

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Parent vessel occlusion for treatment of cerebral aneurysms: Is there still an indication? A series of 17 patients., Nishant Ganesh Kumar, Travis R Ladner, Imad S Kahn, Scott L Zuckerman, Christopher B Baker, Deborah Cushing, Matthew R Sanborn, J Mocco, and Robert D Ecker

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Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy., Timothy P Fitzgibbons, Yvonne J K Edwards, Peter Shaw, Aline Iskandar, Mohamed Ahmed, Josiah Bote, Tejen Shah, Sumita Sinha, Robert E Gerszten, John F Keaney, Michael R Zile, and Gerard P Aurigemma

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Airway management and mechanical ventilation in acute brain injury., D B Seder and J Bösel

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An Investigation of the Relationship Between Emergency Medicine Trainee Burnout and Clinical Performance in a High-fidelity Simulation Environment., Dave W Lu, Scott M Dresden, D Mark Courtney, and David H Salzman

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A Quality Improvement Program to Reduce Potential Overtreatment of Diabetes Among Veterans at High Risk of Hypoglycemia., Versha G. Vimalandanda, Kristine DeSotto, TeChieh Chen, Jenny Mullakary, James Schlosser, Cliona Archambeault, Jordan Peck, Hannah Cassidy, Paul R. Conlin, Stewart Evans, Mark McConnell, and Eric Shirley

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Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature., Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, and Christine M Sorenson

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Can creating a Behavioral Task Force on the medical and surgical floor increase staff satisfaction rates?, Amy Lee

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Corrigendum: Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men., Daniel Price, Debra Burris, Anna Cloutier, Carol B Thompson, James K Rilling, and Richmond R Thompson

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Development of a Traumatic Brain Injury (TBI) Order Set at Maine Medical Center, Sarah Bockian, Emily Esslinger, and Martha Weatherhead

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Development of a Traumatic Brain Injury (TBI) Order Set at Maine Medical Center, Sarah Bockian, Emily Esslinger, and Martha Weatherhead

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Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest)., Rea P Anunciado-Koza, Justin Manuel, Randall L Mynatt, Jingying Zhang, Leslie P Kozak, and Robert A Koza

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Does medication safety and diversion education improve medication securement practices in SCU compared to current practice?, Natasha Stankiewicz

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Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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First-trimester chorionic bump--association with fetal aneuploidy in a high-risk population., Joseph R Wax, Angelina Cartin, Christian Litton, Michael G Pinette, and F L Lucas

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Growth factor regulation in the nephrogenic zone of the developing kidney., Leif Oxburgh, Sree Deepthi Muthukrishnan, and Aaron Brown