Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2016

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Multimodal Eph/Ephrin signaling controls several phases of urogenital development., Christiane Peuckert, Bejan Aresh, Pavlo Holenya, Derek Adams, Smitha Sreedharan, Annika Porthin, Louise Andersson, Hanna Pettersson, Stefan Wölfl, Rüdiger Klein, Leif Oxburgh, and Klas Kullander

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PPARG post-translational modifications regulate bone formation and bone resorption., L A Stechschulte, P J Czernik, Z C Rotter, F N Tausif, C A Corzo, D P Marciano, A Asteian, J Zheng, J B Bruning, T M Kamenecka, C J. Rosen, P R Griffin, and B Lecka-Czernik

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Prostate cancer: radiotherapy might improve survival, even in the oldest men., Stephen T. Ryan and Jesse D. Sammon

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Selecting clinical diagnoses: logical strategies informed by experience., Donald Edward Stanley and Daniel G Campos

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Surgical management of osteoarthritis of the knee: evidence-based guideline., Brian J J. McGrory, Kristy L Weber, David S Jevsevar, and Kaitlyn Sevarino

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The Future of the Academic Cardiothoracic Surgeon: Results of the TSRA/TSDA In-Training Examination Survey., Elizabeth H Stephens, Asad A Shah, Michael P Robich, Dustin M Walters, Walter F DeNino, Muhammad Aftab, Vakhtang Tchantchaleishvili, Amanda L Eilers, Robert D Rice, Andrew B Goldstone, Ryan C Shelstad, Tarek Malas, Marisa Cevasco, Erin A Gillaspie, and Damien J LaPar

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Thrombotic complications following the administration of high-dose prothrombin complex concentrate for acute warfarin reversal., Wesley R Zemrak, Erin Kelley, Nicole L Kovacic, Deirdre M Mooney, Jane G Morris, Casey Z MacVane, and Jeffrey A Rosenblatt

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Workplace violence in health care - it's not "part of the job"., Joseph R. Wax, Michael G. Pinette, and Angelina Cartin

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Cardiac and renovascular complications in type 2 diabetes--is there hope?, Julie R. Ingelfinger and Clifford J. Rosen

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BMP antagonist Gremlin 2 limits inflammation after myocardial infarction., Lehanna N Sanders, John A Schoenhard, Mohamed A Saleh, Amrita Mukherjee, Sergey Ryzhov, William G McMaster, Kristof Nolan, Richard J Gumina, Thomas B Thompson, Mark A Magnuson, David G Harrison, and Antonis K Hatzopoulos

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Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus., Mohammed Talha Shekhani, Toni S Forde, Altynai Adilbayeva, Mohamed Ramez, Askhat Myngbay, Yergali Bexeitov, Volkhard Lindner, and Vyacheslav A Adarichev

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MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling., Jino Park, Soojin Kim, Joongho Joh, Scot C. Remick, Donald M Miller, Jun Yan, Zeyad Kanaan, Ju-Hsien Chao, Maxwell M Krem, Soumit K Basu, Shotaro Hagiwara, Lukas Kenner, Richard Moriggl, Kevin D Bunting, and William Tse

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CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells., Kathleen A Bishop, Anne Harrington, Evguenia Kouranova, Edward J Weinstein, Clifford J Rosen, Xiaoxia Cui, and Lucy Liaw

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Network analysis implicates Alpha-Synuclein (Snca) in the regulation of ovariectomy-Induced bone loss., Gina Calabrese, Larry D Mesner, Patricia L Foley, Clifford J. Rosen, and Charles R Farber

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Abstract 649: Biobank collaboration enables cancer modeling with high quality biospecimens and data, Lindsay Shopland, Ivette Emery, Todd Hoffert, Rise Aalberg, Petra Helbig, Susan E. LaPierre, Vicky Sanders, Kevin D. Mills, Tara Hill, Aysha Sheikh, Michael Jones, Anne Breggia, and Jens Rueter

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A Day in the Life of a Telehealth Home Healthcare Aide., Mia Millefoglie

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Biomarkers p16, Human Papillomavirus and p53 Predict Recurrence and Survival in Early Stage Squamous Cell Carcinoma of the Vulva., Casey M Hay, Jason A Lachance, F L Lucas, Kahsi A Smith, and Michael A Jones

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Difference in effectiveness of medication adherence intervention by health literacy level., Ashli A Owen-Smith, David H Smith, Cynthia S Rand, Jeffrey O Tom, Reesa Laws, Amy Waterbury, Andrew Williams, and William M Vollmer

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Does bathing frequency matter in pediatric atopic dermatitis?, Ivan D. Cardona, Leland Stillman, and Neal Jain

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Gender and Cardiothoracic Surgery Training: Specialty Interests, Satisfaction, and Career Pathways., Elizabeth H Stephens, Michael P Robich, Dustin M Walters, Walter F DeNino, Muhammad Aftab, Vakhtang Tchantchaleishvili, Amanda L Eilers, Robert D Rice, Andrew B Goldstone, Ryan C Shlestad, Tarek Malas, Marisa Cevasco, Erin A Gillaspie, Amy G Fiedler, Damien J LaPar, and Asad A Shah

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Novel biological therapies targeting heart failure: myocardial rejuvenation., Amanda J. Favreau-Lessard, Sergey Ryzhov, and Douglas B. Sawyer

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Randomized phase II evaluation of bevacizumab versus bevacizumab plus fosbretabulin in recurrent ovarian, tubal, or peritoneal carcinoma: an NRG Oncology/Gynecologic Oncology Group study., Bradley J Monk, Michael W Sill, Joan L Walker, Christopher J. Darus, Gregory Sutton, Krishnansu S Tewari, Lainie P Martin, Jeanne M Schilder, Robert L Coleman, Jai Balkissoon, and Carol Aghajanian

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Sustainable Mechanism to Reduce Emergency Department (ED) Length of Stay: The Use of ED Holding (ED Transition) Orders to Reduce ED Length of Stay., Samir A Haydar, Tania D Strout, and Michael R Baumann

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Sustainable Mechanism to Reduce Emergency Department (ED) Length of Stay: The Use of ED Holding (ED Transition) Orders to Reduce ED Length of Stay., Samir A. Haydar, Tania D. Strout, Michael R. Baumann, and Mark Hauswald

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The bioengineered kidney: science or science fiction?, Leif Oxburgh and Thomas J Carroll

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Treatment of Distal Anterior Circulation Aneurysms With the Pipeline Embolization Device: A US Multicenter Experience., Ning Lin, Giuseppe Lanzino, Demetrius K Lopes, Adam S Arthur, Christopher S Ogilvy, Robert D Ecker, Travis M Dumont, Raymond D Turner, M Reid Gooch, Alan S Boulos, Peter Kan, Kenneth V Snyder, Elad I Levy, and Adnan H Siddiqui

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Use and misuse of opioids in Maine: results from pharmacists, the prescription monitoring, and the diversion alert programs., Brian J Piper, Clare E Desrosiers, John W Lipovsky, Matthew A Rodney, Robert P Baker, Kenneth L McCall, Stephanie D. Nichols, and Sarah L Martin

Workplace Violence in Health Care--It's Not "Part of the Job"., Joseph R. Wax, Michael G. Pinette, and Angelina Cartin

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Nonvitamin K anticoagulant agents in patients with advanced chronic kidney disease or on dialysis with AF., Kevin E Chan, Robert P Giugliano, Manesh R Patel, Stuart Abramson, Meg Jardine, Sophia Zhao, Vlado Perkovic, Franklin W Maddux, and Jonathan P Piccini

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Early debris formation with a porous tantalum glenoid component: radiographic analysis with 2-year minimum follow-up., Donald P. Endrizzi, Johanna A. Mackenzie, and Patrick D G Henry

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Scanning electron microscopy of macerated tissue to visualize the extracellular matrix., Matthew K Stephenson, Sean Lenihan, Roman Covarrubias, Ryan M Huttinger, Richard J Gumina, Douglas B. Sawyer, and Cristi L Galindo

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A multistate model predicting mortality, length of stay, and readmission for surgical patients., David E Clark, Kaitlin R Ostrander, and Brad M Cushing

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Appraisal of the Quality of Neurosurgery Clinical Practice Guidelines., Katrina Ducis, Jeffrey E Florman, and Anand I Rughani

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A randomized trial of videoconference-delivered cognitive behavioral therapy for survivors of breast cancer with self-reported cognitive dysfunction., Robert J. Ferguson, Sandra T. Sigmon, Andrew J. Pritchard, Sharon L. LaBrie, Rachel E. Goetze, Christine M. Fink, and A Merrill Garrett

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A Retrospective Chart Review of Bleeding After Circumcision to Build Evidence-Based Practice in Newborn Care., Patircia Crosby and Julie V. Fortier

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Biophysical and biochemical screening for the risk of preterm labor: an update., Joseph R. Wax, Angelina Cartin, and Michael G. Pinette

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Bone marrow adipose tissue: formation, function and regulation., Karla J Suchacki, William P Cawthorn, and Clifford J Rosen

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Building a patient-reported outcome metric database: one hospital's experience., Adam J. Rana

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Could Clinical Outcome Registries Bring Us Closer to Consensus?, Robert C Groom

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Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice., M J Devlin, D J Brooks, C Conlon, M van Vliet, L Louis, C J. Rosen, and M L Bouxsein

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Delirium recall - an integrative review., Valerie Fuller

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Development: Unique genetic determinants of human kidney development., Leif Oxburgh

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Diagnosis and Management of Hematuria., Gabriella J Avellino, Sanchita Bose, and David S Wang

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Diagnosis and management of lower urinary tract dysfunction., Robert C. McDonough and Stephen T. Ryan

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Diagnosis and surgical management of male pelvic, inguinal, and testicular pain., Gabriel V. Belanger and Graham T. VerLee

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Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores., Mary Ann Asson-Batres, Sergey Ryzhov, Oleg Tikhomirov, Christine W Duarte, Clare Bates Congdon, Craig R Lessard, Samuel McFarland, Cecile Rochette-Egly, Truc-Linh Tran, Cristi L Galindo, Amanda J Favreau-Lessard, and Douglas B Sawyer

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Enhancing Nephrology Career Interest through the ASN Kidney TREKS Program., Laura J Maursetter, Lauren D Stern, Stephen M Sozio, Ankit B Patel, Reena Rao, Hitesh H Shah, Katlyn Leight, Mark D Okusa, Mark L Zeidel, and Mark G Parker

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Gender incongruity in children with and without disorders of sexual differentiation., Jerrold Olshan, Toni Eimicke, and Erin Belfort

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Genetic counseling for patients considering screening and diagnosis for chromosomal abnormalities., Renée L. Chard and Mary E Norton

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Getting the SCOOP-survey of cardiovascular outcomes from oncology patients during survivorship., Nirmanmoh Bhatia, Daniel Lenihan, Douglas B. Sawyer, and Carrie G Lenneman

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Hypofractionated Conformal Radiotherapy with Concurrent Full-Dose Gemcitabine Versus Standard Fractionation Radiotherapy with Concurrent Fluorouracil for Unresectable Pancreatic Cancer: a Multi-Institution Experience., Sunpreet Rakhra, Jonathan B Strauss, John Robertson, Cornelius J McGinn, Thomas Kim, Jiayi Huang, Andrew Blake, Irene Helenowski, John P Hayes, Mary Mulcahy, and William Small

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Inhibition of ovarian tumor growth by targeting the HU177 cryptic collagen epitope., Jennifer M M. Caron, Jacquelyn J. Ames, Liangru Contois, Leonard Liebes, Robert Friesel, Franco Muggia, Calvin PH Vary, Leif Oxburgh, and Peter C Brooks

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In reply to Brillhart et al., Chris R Welter, J Matthew Sholl, Tania D Strout, and Ben Woodard

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IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation., Gang Xi, Xinchun Shen, Clifford J Rosen, and David R Clemmons

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Optimising health and safety of people who inject drugs during transition from acute to outpatient care: narrative review with clinical checklist., Kinna Thakarar, Zoe M Weinstein, and Alexander Y Walley

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Pediatric urology for the general surgeon., David J. Chalmers and Vijaya M Vemulakonda

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Peripheral atherectomy: applications and techniques., Derek Mittleider and Erich Russell

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Preface., Lisa T. Beaule and Moritz H. Hansen

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Prescription Monitoring Program Trends Among Individuals Arrested in Maine for Trafficking Prescription Drugs in 2014., Kenneth McCall, Stephanie D Nichols, Christina Holt, Leslie Ochs, Gary Cattabriga, and Chunhao Tu

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Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes., Shantanu N Razdan, Vishal Patel, Sarah Jewell, and Colleen M McCarthy

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Stromal β-catenin overexpression contributes to the pathogenesis of renal dysplasia., Felix J Boivin, Sanjay Sarin, Pari Dabas, Michele Karolak, Leif Oxburgh, and Darren Bridgewater

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The National Children's Study: recruitment outcomes using an enhanced household-based approach., Laura L. Blaisdell, Jennifer A Zellner, Alison A King, Elaine Faustman, Mari Wilhelm, Mark L Hudak, and Robert D Annett

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The Role of the Psychiatry Resident in Integrative Behavioral Care., Anna Katharina Trede

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The use of bowel in urologic reconstructive surgery., Moritz H. Hansen, Matthew Hayn, and Patrick Murray

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Urologic emergencies., Adam E. Ludvigson and Lisa T. Beaule

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Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer., Maria Raffaella Ambrosio, Claudia Di Serio, Giovanna Danza, Bruno Jim Rocca, Alessandro Ginori, Igor Prudovsky, Niccolò Marchionni, Maria Teresa Del Vecchio, and Francesca Tarantini

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Academic emergency medicine physicians' knowledge of mechanical ventilation., Susan R Wilcox, Tania D. Strout, Jeffrey I Schneider, Patricia M Mitchell, Jessica Smith, Lucienne Lutfy-Clayton, Evie G Marcolini, Ani Aydin, Todd A Seigel, and Jeremy B Richards

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Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet., Rea P Anunciado-Koza, David C Higgins, and Robert A Koza

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Cervical Flap After Trachelectomy to Maintain Vaginal Length., Patricia Lynn Hudson and Mary C Brandes

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Early Detection, Intervention and Prevention of Psychosis Program: Community Outreach and Early Identification at Six U.S. Sites., Sarah Lynch, William R McFarlane, Brenda Joly, Steven Adelsheim, Andrea Auther, Barbara A Cornblatt, Margaret Migliorati, J Daniel Ragland, Tamara Sale, Elizabeth Spring, Roderick Calkins, Cameron S Carter, Rebecca Jaynes, Stephan F Taylor, and Donna Downing

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Falls in A Tertiary Care Hospital-Association With Delirium: A Replication Study., Rhonda L Babine, Kristiina E Hyrkäs, Deborah A Bachand, Joanne L Chapman, Valerie J Fuller, Cynthia A Honess, and Heidi R Wierman

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Guidewire Assisted Complete Endoscopic Division of a Windsock Duodenal Diverticulum: The Roping and Transecting Technique., John Walker, Matthew Warndorf, David Y. Lo, and Douglas A. Howell

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Improving Technology Permits Accurate Diagnosis and Localization of Main Duct IPMN...2016 DDW (Digestive Disease Week) ASGE (American Society for Gastrointestinal Endoscopy) Program and Abstracts 21 May 2016-24 May 2016, San Diego, California, Matthew Warndorf, John Walker, Gene Bakis, Andreas Stefan, and Douglas A. Howell

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Sa1003 Alcohol Flush and Flex Protocol to Decrease the Risk of Residual Bacterial Colonization Prior to EUS or Duodenoscope Insertion: Preliminary Experience., Matthew Warndorf, David A. Klibanksy, Daniil Rolshud, Andreas Stefan, August J. Valenti, and Douglas A. Howell

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Targeting vasculogenesis to prevent progression in multiple myeloma., M Moschetta, Y Mishima, Y Kawano, S Manier, B Paiva, L Palomera, Y Aljawai, A Calcinotto, C Unitt, I Sahin, A Sacco, S Glavey, J Shi, M R Reagan, F Prosper, M Bellone, M Chesi, L P Bergsagel, A Vacca, A M Roccaro, and I M Ghobrial

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The Use of Enteric Contrast Media for Diagnostic CT, MRI, and Ultrasound in Infants and Children: A Practical Approach., Michael J Callahan, Jennifer M Talmadge, Robert MacDougall, Carlo Buonomo, and George A Taylor

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Tu1522 Endoscopic Tissue Diagnosis of Cholangiocarcinoma; Is Directed Biopsy Needed?...2016 DDW (Digestive Disease Week) ASGE (American Society for Gastrointestinal Endoscopy) Program and Abstracts 21 May 2016-24 May 2016, San Diego, California, John Walker, Matthew Warndorf, Lisa Rutstein, Hagen Blaszyk, and Douglas A. Howell

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Unknown Risks: Parental Hesitation about Vaccination., Laura L Blaisdell, Caitlin Gutheil, Norbert A M Hootsmans, and Paul K J Han

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Gemtuzumab Ozogamicin Reduces Relapse Risk in FLT3/ITD Acute Myeloid Leukemia: A Report from the Children's Oncology Group., Katherine Tarlock, Todd A Alonzo, Robert B Gerbing, Susana C Raimondi, Betsy A Hirsch, Lillian Sung, Jessica A Pollard, Richard Aplenc, Michael R Loken, Alan S Gamis, and Soheil Meshinchi

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Determinants of prostate specific antigen screening among black men in the United States in the contemporary era., Deepansh Dalela, Firas Abdollah, Toni K Choueiri, Paul K Han, Moritz Hansen, Paul L Nguyen, Akshay Sood, Mani Menon, Quoc-Dien Trinh, and Jesse Sammon

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Early tracheostomy in ventilated stroke patients: Study protocol of the international multicentre randomized trial SETPOINT2 (Stroke-related Early Tracheostomy vs. Prolonged Orotracheal Intubation in Neurocritical care Trial 2)., Silvia Schönenberger, Wolf-Dirk Niesen, Hannah Fuhrer, Colleen Bauza, Christina Klose, Meinhard Kieser, José I Suarez, David B Seder, Julian Bösel, SETPOINT2-Study Group, and IGNITE-Study Group

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Evolving hemodynamics on intra-aortic balloon pump support in takotsubo cardiomyopathy., Waseem Chaudhry and Esther Shao

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Extracellular nucleotide regulation and signaling in cardiac fibrosis., Tatiana Novitskaya, Elena Chepurko, Roman Covarrubias, Sergey Novitskiy, Sergey V Ryzhov, Igor Feoktistov, and Richard J Gumina

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Knowledge and values for cancer screening decisions: results from a national survey., Richard M Hoffman, Joann G Elmore, Michael P Pignone, Bethany S Gerstein, Carrie A Levin, and Kathleen M Fairfield

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Physical Activity and the Risk of Primary Hyperparathyroidism., Anand Vaidya, Gary C Curhan, Julie M Paik, Molin Wang, and Eric N Taylor

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Same-Day Discharge Following Laparoscopic Appendectomy for Uncomplicated Acute Appendicitis as a Measure of Quality in the Pediatric Population., Jeffrey M Halter, Baird Mallory, Ian R Neilson, and Monica Langer

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Surgical adjuncts to noncompressible torso hemorrhage as tools for patient blood management., Joseph F Rappold and Grant V Bochicchio

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Targeting Simulation-Based Assessment for the Pediatric Milestones: A Survey of Simulation Experts and Program Directors., Leah A. Mallory, Sharon Calaman, Marjorie Lee White, Cara Doughty, Karen Mangold, Joseph Lopreiato, Marc Auerbach, and Todd P. Chang

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Cardio-Oncology: An Update on Cardiotoxicity of Cancer-Related Treatment., Carrie G Lenneman and Douglas B Sawyer

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RAS/MAPK activation Is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: therapeutic cooperation between MEK and PD-1/PD-L1 immune checkpoint inhibitors., Sherene Loi, Sathana Dushyanthen, Paul A Beavis, Roberto Salgado, Carsten Denkert, Peter Savas, Susan Combs, David L Rimm, Jennifer M Giltnane, Monica V Estrada, Violeta Sánchez, Melinda E Sanders, Rebecca S Cook, Mark A Pilkinton, Simon A Mallal, Kai Wang, Vincent A Miller, Phil J Stephens, Roman Yelensky, Franco D Doimi, Henry Gómez, Sergey V Ryzhov, Phillip K Darcy, Carlos L Arteaga, and Justin M Balko

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Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype., Qing He, Hongyu Jing, Lucy Liaw, Lindsey Gower, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Aberrant expression of Twist1 in diseased articular cartilage and a potential role in the modulation of osteoarthritis severity., Rosa M Guzzo, Farhang Alaee, David Paglia, Jason D Gibson, Douglas Spicer, and Hicham Drissi

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Acute Kidney Disease After Liver and Heart Transplantation., Ana P Rossi and John P Vella

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A twelve-year consecutive case experience in thoracic reconstruction., Jenny T Chen, Laura A Bonneau, Tracey L. Weigel, James D Maloney, Francisco Castro, Nikita Shulzhenko, and Michael L Bentz

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Building Bridges: Implementing Pedagogical Changes Within Nursing Education and Practice...28th Annual Scientific Session, June 2-6, 2017, Baltimore, Maryland., Kristiina Myrkas, Carla Randall, and Krista Meinersmann

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CD33 Expression and Its Association With Gemtuzumab Ozogamicin Response: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531., Jessica A Pollard, Michael Loken, Robert B Gerbing, Susana C Raimondi, Betsy A Hirsch, Richard Aplenc, Irwin D Bernstein, Alan S Gamis, Todd A Alonzo, and Soheil Meshinchi

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Cost-Effectiveness Analysis of Breast Reconstruction Options in the Setting of Postmastectomy Radiotherapy Using the BREAST-Q., Shantanu N Razdan, Peter G Cordeiro, Claudia R Albornoz, Teresa Ro, Wess A Cohen, Babak J Mehrara, Colleen M McCarthy, Joseph J Disa, Andrea L Pusic, and Evan Matros

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Cultural Sensitivity and Challenges in Management of the Transgender Patient With ESRD in Transplantation., Deborah Ann Hoch, Maya Bulman, and Dorn W McMahon

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Direct and Indirect Costs Following Living Kidney Donation: Findings From the KDOC Study., J R Rodrigue, J D Schold, P Morrissey, J Whiting, J Vella, L K Kayler, D Katz, J Jones, B Kaplan, A Fleishman, M Pavlakis, and D A Mandelbrot

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Growth of human breast tissues from patient cells in 3D hydrogel scaffolds., Ethan S Sokol, Daniel H Miller, Anne Breggia, Kevin C Spencer, Lisa M Arendt, and Piyush B Gupta