Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. MaineHealth Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2016

Implementation of a COPD inpatient clinical pathway with a dedicated respiratory therapist team., Sally Brewer, Sally Whitten, and John Dziodzio

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Intended and unintended consequences of constraining clinician prescribing: the case of antipsychotics., John W Devlin, Pamela Smithburger, Jason M Kane, Gilles L. Fraser, and Yoanna Skrobik

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Inter-rater reliability of the APD, SFU and UTD grading systems in fetal sonography and MRI., D J. Chalmers, M L Meyers, K E Brodie, C Palmer, and J B Campbell

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Personalized prediction of psychosis: external validation of the NAPLS-2 psychosis risk calculator with the EDIPPP Project., Ricardo E Carrión, Barbara A Cornblatt, Cynthia Z Burton, Ivy F Tso, Andrea M Auther, Steven Adelsheim, Roderick Calkins, Cameron S Carter, Tara Niendam, Tamara G Sale, Stephan F Taylor, and William R. McFarlane

Photo Quiz 360®. Last Issue's Answer: Sweet Syndrome., Katherine G. Garlo, Nicholas Perros, Robert Smith, and Katy Linskey

Phot Quiz 360. New Rash and Fever in a Woman With Inflammatory Bowel Disease., Katherine G. Garlo, Nicholas Perros, Robert Smith, and Katy Linskey

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Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss., U T Iwaniec, K A Philbrick, C P Wong, J L Gordon, A M Kahler-Quesada, D A Olson, A J Branscum, J L Sargent, V E DeMambro, C J Rosen, and R T Turner

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Sedation quality in intensive care: which interventions work?, Richard R. Riker and Gilles L. Fraser

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Sef Regulates Epithelial-Mesenchymal Transition in Breast Cancer Cells., Qing He, Yan Gong, Lindsey Gower, Xuehui Yang, and Robert E Friesel

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Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study., Geoffrey Buckle, Louise Maranda, Jodi Skiles, John Michael Ong'echa, Joslyn Foley, Mara Epstein, Terry A Vik, Andrew Schroeder, Jennifer Lemberger, Alan Rosmarin, Scot C Remick, Jeffrey A Bailey, John Vulule, Juliana A Otieno, and Ann M Moormann

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Abdominal adipose tissue in MGUS and multiple myeloma., Joyce Veld, Elizabeth K O'Donnell, Michaela R. Reagan, Andrew J Yee, Martin Torriani, Clifford J. Rosen, and Miriam A Bredella

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A case of possible iatrogenic ketamine-Induced mania in a patient being treated for postoperative pain., Stephanie D. Nichols, Maya Bulman, Annya Tisher, and John J. Campbell

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Collaborative care and integration: changing roles and changing Identity of the child and adolescent psychiatrist?, Sandra L. Fritsch, Abigail Schlesinger, Amy D Habeger, Barry Sarvet, and Joyce N Harrison

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Decompressive craniectomy for severe traumatic brain injury: clinical study, literature review and meta-analysis., Gene A. Grindlinger, David H. Skavdahl, Robert D. Ecker, and Matthew R. Sanborn

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Family Interventions for Schizophrenia and the Psychoses: A Review., William R McFarlane

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Family Interventions for Schizophrenia and the Psychoses: A Review., William R. McFarlane

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From Guidelines to Practice: How Do Clinical Practice Standards Align with Established Recommendations for Duration of Parenteral Nutrition Therapy?, S Tate, M Creech, and L Tate

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Geographic access to interventional cardiology services in one rural state., James P Rhudy, Anne W Alexandrov, Kristiina E Hyrkäs, Rita A Jablonski-Jaudon, Erica R Pryor, Henry E Wang, and Marie A Bakitas

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How to implement alternative payment models in your total joint arthroplasty practice., Adam J. Rana

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HP1BP3 expression determines maternal behavior and offspring survival., B P Garfinkel, S Arad, S M Neuner, S Netser, S Wagner, C C Kaczorowski, C J. Rosen, M Gal, H Soreq, and J Orly

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Insights Into nephrolithiasis from the Nurses' Health Studies., Megan L Prochaska, Eric N. Taylor, and Gary C Curhan

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Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships With Mouse Adipose Tissues., Lucy Liaw, Igor Prudovsky, Robert A Koza, Rea V Anunciado-Koza, Matthew E Siviski, Volkhard Lindner, Robert E Friesel, Clifford J Rosen, Paul R S Baker, Brigitte Simons, and Calvin P H Vary

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Method of Meal Tray Delivery, Timing of Blood Glucose Testing and Insulin Administration. A Pilot Study., A T. Truong

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Narcotic Independence After Pancreatic Duct Stenting Predicts Narcotic Independence After Lateral Pancreaticojejunostomy for Chronic Pancreatitis., Richard S Kwon, Benjamin E Young, William F Marsteller, Christopher Lawrence, Bechien U Wu, Linda S Lee, Daniel Mullady, David A Klibansky, Timothy B Gardner, and Diane M Simeone

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Premeasured chordal loops for mitral valve repair., Marc Gillinov, Reed Quinn, Faraz Kerendi, Vince Gaudiani, Richard Shemin, Glenn Barnhart, Edward Raines, Marc W Gerdisch, and Michael Banbury

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Shared decision-making as an existential journey: aiming for restored autonomous capacity., Pål Gulbrandsen, Marla L Clayman, Mary Catherine Beach, Paul K. Han, Emily F Boss, Eirik H Ofstad, and Glyn Elwyn

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The chorionic bump: etiologic insights from two pathologic pregnancies., Joseph R. Wax, Hagen Blaszyk, Michael Jones, Angelina Cartin, and Michael G. Pinette

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The effect of a 4-hour moderate and 1-hour intense exercise session versus resting condition on luteinizing hormone (LH) level, variation, and pulsatility in six healthy male subjects., J L. Chiang, M P. Leondires, Wendy Craig, F L. Lucas, and D I. Spratt

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The health and libraries of public use retrospective study (HeLPURS)., Sam Zager, Amy Haskins, Katherine Maland, and Christina Holt

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AAOS Clinical Practice Guideline: Surgical Management of Osteoarthritis of the Knee: evidence-based guideline., Kristy L Weber, David S Jevsevar, and Brian J. McGrory

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A blown pupil and intracranial hemorrhage in a 4-week-old: a case of delayed onset vitamin K deficiency bleeding, a rare "can't miss" diagnosis., Ryley Enz and Robert S. Anderson Jr

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A dimeric peptide with erythropoiesis-stimulating activity uniquely affects erythropoietin receptor ligation and cell surface expression., Rakesh Verma, Jennifer M Green, Peter J Schatz, and Don M Wojchowski

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Assessing patients' experiences with communication across the cancer care continuum., Kathleen M Mazor, Richard L Street, Valerie M Sue, Andrew E Williams, Borsika A Rabin, and Neeraj K Arora

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Clinical and research considerations for patients with hypertensive acute heart failure: a consensus statement from the Society for Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group., Sean P Collins, Phillip D Levy, Jennifer L Martindale, Mark E Dunlap, Alan B Storrow, Peter S Pang, Nancy M Albert, G Michael Felker, Gregory J Fermann, Gregg C Fonarow, Michael M Givertz, Judd E Hollander, David E Lanfear, Daniel J Lenihan, JoAnn M Lindenfeld, W Frank Peacock, Douglas B. Sawyer, John R Teerlink, and Javed Butler

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Clinical and research considerations for patients with hypertensive acute heart failure: a consensus statement from the Society of Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group., Sean P Collins, Phillip D Levy, Jennifer L Martindale, Mark E Dunlap, Alan B Storrow, Peter S Pang, Nancy M Albert, G Michael Felker, Gregory J Fermann, Gregg C Fonarow, Michael M Givertz, Judd E Hollander, David J Lanfear, Daniel J Lenihan, JoAnn M Lindenfeld, W Frank Peacock, Douglas B. Sawyer, John R Teerlink, and Javed Butler

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Determinants of cancer screening in Asian-Americans., Quoc-Dien Trinh, Hanhan Li, Christian P Meyer, Julian Hanske, Toni K Choueiri, Gally Reznor, Stuart R Lipsitz, Adam S Kibel, Paul K. Han, Paul L Nguyen, Mani Menon, and Jesse D Sammon

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Factors Affecting Physicians' Intentions to Communicate Personalized Prognostic Information to Cancer Patients at the End of Life: An Experimental Vignette Study., Paul K J Han, Nathan F Dieckmann, Christina Holt, Caitlin Gutheil, and Ellen Peters

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Free serum valproate concentration more reliable than total concentration in critically ill patients., Colman Hatton, Richard R. Riker, David J. Gagnon, Teresa May, David B. Seder, and Gilles L. Fraser

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Health literacy-listening skill and patient questions following cancer prevention and screening discussions., Kathleen M Mazor, Donald L Rubin, Douglas W Roblin, Andrew E Williams, Paul K J Han, Bridget Gaglio, Sarah L Cutrona, Mary E Costanza, and Joann L Wagner

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Holmium laser for the surgical treatment of benign prostatic hyperplasia., Portia Thurmond, Sanchita Bose, and Lori B Lerner

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Managing the patient with pulmonary hypertension: specialty care centers, coordinated care, and patient support., Murali M Chakinala, Maribeth Duncan, and Joel Wirth

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Maternal Antiretroviral Therapy Is Associated with Lower Risk of Diarrhea in Early Childhood., Kevin A Sztam, Enju Liu, Karim P Manji, Roland Kupka, Rodrick Kisenge, Said Aboud, Wafaie W Fawzi, Ronald J Bosch, and Christopher P Duggan

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MCT8 deficiency in male mice mitigates the phenotypic abnormalities associated with the absence of a functional type 3 deiodinase., J Patrizia Stohn, M Elena Martinez, Kassey Matoin, Beatriz Morte, Juan Bernal, Valerie Anne Galton, Donald St Germain, and Arturo Hernandez

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Multimodal Eph/Ephrin signaling controls several phases of urogenital development., Christiane Peuckert, Bejan Aresh, Pavlo Holenya, Derek Adams, Smitha Sreedharan, Annika Porthin, Louise Andersson, Hanna Pettersson, Stefan Wölfl, Rüdiger Klein, Leif Oxburgh, and Klas Kullander

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PPARG post-translational modifications regulate bone formation and bone resorption., L A Stechschulte, P J Czernik, Z C Rotter, F N Tausif, C A Corzo, D P Marciano, A Asteian, J Zheng, J B Bruning, T M Kamenecka, C J. Rosen, P R Griffin, and B Lecka-Czernik

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Prostate cancer: radiotherapy might improve survival, even in the oldest men., Stephen T. Ryan and Jesse D. Sammon

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Selecting clinical diagnoses: logical strategies informed by experience., Donald Edward Stanley and Daniel G Campos

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Surgical management of osteoarthritis of the knee: evidence-based guideline., Brian J J. McGrory, Kristy L Weber, David S Jevsevar, and Kaitlyn Sevarino

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The Future of the Academic Cardiothoracic Surgeon: Results of the TSRA/TSDA In-Training Examination Survey., Elizabeth H Stephens, Asad A Shah, Michael P Robich, Dustin M Walters, Walter F DeNino, Muhammad Aftab, Vakhtang Tchantchaleishvili, Amanda L Eilers, Robert D Rice, Andrew B Goldstone, Ryan C Shelstad, Tarek Malas, Marisa Cevasco, Erin A Gillaspie, and Damien J LaPar

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Thrombotic complications following the administration of high-dose prothrombin complex concentrate for acute warfarin reversal., Wesley R Zemrak, Erin Kelley, Nicole L Kovacic, Deirdre M Mooney, Jane G Morris, Casey Z MacVane, and Jeffrey A Rosenblatt

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Workplace violence in health care - it's not "part of the job"., Joseph R. Wax, Michael G. Pinette, and Angelina Cartin

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Cardiac and renovascular complications in type 2 diabetes--is there hope?, Julie R. Ingelfinger and Clifford J. Rosen

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BMP antagonist Gremlin 2 limits inflammation after myocardial infarction., Lehanna N Sanders, John A Schoenhard, Mohamed A Saleh, Amrita Mukherjee, Sergey Ryzhov, William G McMaster, Kristof Nolan, Richard J Gumina, Thomas B Thompson, Mark A Magnuson, David G Harrison, and Antonis K Hatzopoulos

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Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus., Mohammed Talha Shekhani, Toni S Forde, Altynai Adilbayeva, Mohamed Ramez, Askhat Myngbay, Yergali Bexeitov, Volkhard Lindner, and Vyacheslav A Adarichev

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MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling., Jino Park, Soojin Kim, Joongho Joh, Scot C. Remick, Donald M Miller, Jun Yan, Zeyad Kanaan, Ju-Hsien Chao, Maxwell M Krem, Soumit K Basu, Shotaro Hagiwara, Lukas Kenner, Richard Moriggl, Kevin D Bunting, and William Tse

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CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells., Kathleen A Bishop, Anne Harrington, Evguenia Kouranova, Edward J Weinstein, Clifford J Rosen, Xiaoxia Cui, and Lucy Liaw

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Network analysis implicates Alpha-Synuclein (Snca) in the regulation of ovariectomy-Induced bone loss., Gina Calabrese, Larry D Mesner, Patricia L Foley, Clifford J. Rosen, and Charles R Farber

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Abstract 649: Biobank collaboration enables cancer modeling with high quality biospecimens and data, Lindsay Shopland, Ivette Emery, Todd Hoffert, Rise Aalberg, Petra Helbig, Susan E. LaPierre, Vicky Sanders, Kevin D. Mills, Tara Hill, Aysha Sheikh, Michael Jones, Anne Breggia, and Jens Rueter

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A Day in the Life of a Telehealth Home Healthcare Aide., Mia Millefoglie

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Biomarkers p16, Human Papillomavirus and p53 Predict Recurrence and Survival in Early Stage Squamous Cell Carcinoma of the Vulva., Casey M Hay, Jason A Lachance, F L Lucas, Kahsi A Smith, and Michael A Jones

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Difference in effectiveness of medication adherence intervention by health literacy level., Ashli A Owen-Smith, David H Smith, Cynthia S Rand, Jeffrey O Tom, Reesa Laws, Amy Waterbury, Andrew Williams, and William M Vollmer

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Does bathing frequency matter in pediatric atopic dermatitis?, Ivan D. Cardona, Leland Stillman, and Neal Jain

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Gender and Cardiothoracic Surgery Training: Specialty Interests, Satisfaction, and Career Pathways., Elizabeth H Stephens, Michael P Robich, Dustin M Walters, Walter F DeNino, Muhammad Aftab, Vakhtang Tchantchaleishvili, Amanda L Eilers, Robert D Rice, Andrew B Goldstone, Ryan C Shlestad, Tarek Malas, Marisa Cevasco, Erin A Gillaspie, Amy G Fiedler, Damien J LaPar, and Asad A Shah

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Novel biological therapies targeting heart failure: myocardial rejuvenation., Amanda J. Favreau-Lessard, Sergey Ryzhov, and Douglas B. Sawyer

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Randomized phase II evaluation of bevacizumab versus bevacizumab plus fosbretabulin in recurrent ovarian, tubal, or peritoneal carcinoma: an NRG Oncology/Gynecologic Oncology Group study., Bradley J Monk, Michael W Sill, Joan L Walker, Christopher J. Darus, Gregory Sutton, Krishnansu S Tewari, Lainie P Martin, Jeanne M Schilder, Robert L Coleman, Jai Balkissoon, and Carol Aghajanian

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Sustainable Mechanism to Reduce Emergency Department (ED) Length of Stay: The Use of ED Holding (ED Transition) Orders to Reduce ED Length of Stay., Samir A Haydar, Tania D Strout, and Michael R Baumann

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Sustainable Mechanism to Reduce Emergency Department (ED) Length of Stay: The Use of ED Holding (ED Transition) Orders to Reduce ED Length of Stay., Samir A. Haydar, Tania D. Strout, Michael R. Baumann, and Mark Hauswald

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The bioengineered kidney: science or science fiction?, Leif Oxburgh and Thomas J Carroll

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Treatment of Distal Anterior Circulation Aneurysms With the Pipeline Embolization Device: A US Multicenter Experience., Ning Lin, Giuseppe Lanzino, Demetrius K Lopes, Adam S Arthur, Christopher S Ogilvy, Robert D Ecker, Travis M Dumont, Raymond D Turner, M Reid Gooch, Alan S Boulos, Peter Kan, Kenneth V Snyder, Elad I Levy, and Adnan H Siddiqui

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Use and misuse of opioids in Maine: results from pharmacists, the prescription monitoring, and the diversion alert programs., Brian J Piper, Clare E Desrosiers, John W Lipovsky, Matthew A Rodney, Robert P Baker, Kenneth L McCall, Stephanie D. Nichols, and Sarah L Martin

Workplace Violence in Health Care--It's Not "Part of the Job"., Joseph R. Wax, Michael G. Pinette, and Angelina Cartin

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Nonvitamin K anticoagulant agents in patients with advanced chronic kidney disease or on dialysis with AF., Kevin E Chan, Robert P Giugliano, Manesh R Patel, Stuart Abramson, Meg Jardine, Sophia Zhao, Vlado Perkovic, Franklin W Maddux, and Jonathan P Piccini

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Early debris formation with a porous tantalum glenoid component: radiographic analysis with 2-year minimum follow-up., Donald P. Endrizzi, Johanna A. Mackenzie, and Patrick D G Henry

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Scanning electron microscopy of macerated tissue to visualize the extracellular matrix., Matthew K Stephenson, Sean Lenihan, Roman Covarrubias, Ryan M Huttinger, Richard J Gumina, Douglas B. Sawyer, and Cristi L Galindo

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A multistate model predicting mortality, length of stay, and readmission for surgical patients., David E Clark, Kaitlin R Ostrander, and Brad M Cushing

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Appraisal of the Quality of Neurosurgery Clinical Practice Guidelines., Katrina Ducis, Jeffrey E Florman, and Anand I Rughani

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A randomized trial of videoconference-delivered cognitive behavioral therapy for survivors of breast cancer with self-reported cognitive dysfunction., Robert J. Ferguson, Sandra T. Sigmon, Andrew J. Pritchard, Sharon L. LaBrie, Rachel E. Goetze, Christine M. Fink, and A Merrill Garrett

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A Retrospective Chart Review of Bleeding After Circumcision to Build Evidence-Based Practice in Newborn Care., Patircia Crosby and Julie V. Fortier

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Biophysical and biochemical screening for the risk of preterm labor: an update., Joseph R. Wax, Angelina Cartin, and Michael G. Pinette

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Bone marrow adipose tissue: formation, function and regulation., Karla J Suchacki, William P Cawthorn, and Clifford J Rosen

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Building a patient-reported outcome metric database: one hospital's experience., Adam J. Rana

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Could Clinical Outcome Registries Bring Us Closer to Consensus?, Robert C Groom

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Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice., M J Devlin, D J Brooks, C Conlon, M van Vliet, L Louis, C J. Rosen, and M L Bouxsein

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Delirium recall - an integrative review., Valerie Fuller

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Development: Unique genetic determinants of human kidney development., Leif Oxburgh

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Diagnosis and Management of Hematuria., Gabriella J Avellino, Sanchita Bose, and David S Wang

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Diagnosis and management of lower urinary tract dysfunction., Robert C. McDonough and Stephen T. Ryan

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Diagnosis and surgical management of male pelvic, inguinal, and testicular pain., Gabriel V. Belanger and Graham T. VerLee

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Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores., Mary Ann Asson-Batres, Sergey Ryzhov, Oleg Tikhomirov, Christine W Duarte, Clare Bates Congdon, Craig R Lessard, Samuel McFarland, Cecile Rochette-Egly, Truc-Linh Tran, Cristi L Galindo, Amanda J Favreau-Lessard, and Douglas B Sawyer

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Enhancing Nephrology Career Interest through the ASN Kidney TREKS Program., Laura J Maursetter, Lauren D Stern, Stephen M Sozio, Ankit B Patel, Reena Rao, Hitesh H Shah, Katlyn Leight, Mark D Okusa, Mark L Zeidel, and Mark G Parker

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Gender incongruity in children with and without disorders of sexual differentiation., Jerrold Olshan, Toni Eimicke, and Erin Belfort

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Genetic counseling for patients considering screening and diagnosis for chromosomal abnormalities., Renée L. Chard and Mary E Norton

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Getting the SCOOP-survey of cardiovascular outcomes from oncology patients during survivorship., Nirmanmoh Bhatia, Daniel Lenihan, Douglas B. Sawyer, and Carrie G Lenneman

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Hypofractionated Conformal Radiotherapy with Concurrent Full-Dose Gemcitabine Versus Standard Fractionation Radiotherapy with Concurrent Fluorouracil for Unresectable Pancreatic Cancer: a Multi-Institution Experience., Sunpreet Rakhra, Jonathan B Strauss, John Robertson, Cornelius J McGinn, Thomas Kim, Jiayi Huang, Andrew Blake, Irene Helenowski, John P Hayes, Mary Mulcahy, and William Small

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Inhibition of ovarian tumor growth by targeting the HU177 cryptic collagen epitope., Jennifer M M. Caron, Jacquelyn J. Ames, Liangru Contois, Leonard Liebes, Robert Friesel, Franco Muggia, Calvin PH Vary, Leif Oxburgh, and Peter C Brooks

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In reply to Brillhart et al., Chris R Welter, J Matthew Sholl, Tania D Strout, and Ben Woodard

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IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation., Gang Xi, Xinchun Shen, Clifford J Rosen, and David R Clemmons

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Optimising health and safety of people who inject drugs during transition from acute to outpatient care: narrative review with clinical checklist., Kinna Thakarar, Zoe M Weinstein, and Alexander Y Walley

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Pediatric urology for the general surgeon., David J. Chalmers and Vijaya M Vemulakonda

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Peripheral atherectomy: applications and techniques., Derek Mittleider and Erich Russell