Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. MaineHealth Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2017

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Pioglitazone and risk for bone fracture: safety data from a randomized clinical trial., Catherine M Viscoli, Silvio E Inzucchi, Lawrence H Young, Karl L Insogna, Robin Conwit, Karen L Furie, Mark Gorman, Michael A Kelly, Anne M Lovejoy, and Walter N Kernan

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Project IMPACT pilot report: feasibility of implementing a hospital-to-home transition bundle., Leah A Mallory, Snezana Nena Osorio, B Stephen Prato, Jennifer DiPace, Lisa Schmutter, Paula Soung, Amanda Rogers, William J Woodall, Kayla Burley, Sandra Gage, and David Cooperberg

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Real-time H2 O2 measurements in bone marrow mesenchymal stem cells (MSCs) show increased antioxidant capacity in cells from osteoporotic women., Flavia Román, Carla Urra, Omar Porras, Ana María Pino, Clifford J. Rosen, and Juan Pablo Rodríguez

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Spontaneous elbow hemarthrosis identified by point-of-care ultrasound., David C Mackenzie and Scott McCorvey

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The development of an international standard set of outcomes measures for evaluating the treatment of overactive bladder., S J. Pulliam, C E. Foust-Wright, and A Morse

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Ultrasound gel minimizes third body debris with partial hardware removal in joint arthroplasty., Aidan C McGrory, Lee Replogle, and Donald Endrizzi

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Patient-reported outcome metrics in total joint arthroplasty., Adam Rana and Shaleen Vira

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Social Contexts in Medicine: A Patient-Centered Curriculum Empowering Medical Students to Provide Contextualized Care., Carolyn Drake, Melissa Keeport, Alice Chapman, and Chayan Chakraborti

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Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction., Tom J Parry, Anindita Ganguly, Erika L Troy, J Luis Guerrero, Jennifer F Iaci, Maya Srinivas, Andrea M Vecchione, Donald C Button, Craig S Hackett, Ronald Zolty, Douglas B Sawyer, and Anthony O Caggiano

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Cancer incidence in patients with hereditary hemorrhagic telangiectasia., Christine W. Duarte, Adam W. Black, F Lee Lucas, and Calvin P H Vary

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Cervical spine MRI in patients with negative CT: a prospective, multicenter study of the Research Consortium of New England Centers for Trauma (ReCONECT)., Adrian A Maung, Dirk C Johnson, Kimberly Barre, Thomas Peponis, Tomaz Mesar, George C Velmahos, Daniel McGrail, George Kasotakis, Ronald I Gross, Michael S Rosenblatt, Kristen C Sihler, Robert J Winchell, Walter Cholewczynski, Kathryn L Butler, Stephen R Odom, and Kimberly A Davis

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Diagnosis of Severe Acute Lower Gastrointestinal Bleeding With CTA., Samantha L. Wood, Louis Eubank, and Tania D. Strout

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Factor analysis of the scale of prodromal symptoms: data from the early detection and intervention for the prevention of psychosis program., Ivy F Tso, Stephan F Taylor, Tyler B Grove, Tara Niendam, Steven Adelsheim, Andrea Auther, Barbara Cornblatt, Cameron S Carter, Roderick Calkins, J Daniel Ragland, Tamara Sale, and William R McFarlane

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Human NUMB6 induces epithelial-mesenchymal transition and enhances breast cancer cells migration and Invasion., Aldona A. Karaczyn, Tamara L Adams, Robert Y S Cheng, Nicholas N Matluk, and Joseph M Verdi

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ICU clinicians underestimate breathing discomfort in ventilated subjects., Andrew P Binks, Steven Desjardin, and Richard Riker

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Intensity in End-of-Life Care for Medicare Patients Dying with Melanoma (S741)., Rebecca Hutchinson, Lee Lucas, and Kathleen Fairfield

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Mechanisms of marrow adiposity and its implications for skeletal health., Annegreet G Veldhuis-Vlug and Clifford J Rosen

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Minor papilla endotherapy in patients with ventral duct obstruction: identification and management., Nicholas G Brown, Douglas A. Howell, Brian C Brauer, John Walker, Sachin Wani, and Raj J Shah

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One-year pivotal trial outcomes of the Nellix system for endovascular aneurysm sealing., Jeffrey P Carpenter, Robert Cuff, Clifford Buckley, Christopher Healey, Sajjad Hussain, Michel M P J Reijnen, Jose Trani, and Dittmar Böckler

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Reducing Acute Kidney Injury Due to Contrast Material: How Nurses Can Improve Patient Safety., Peggy Lambert, Kristine Chaisson, Susan Horton, Carmen Petrin, Emily Marshall, Sue Bowden, Lynn Scott, Sheila Conley, Janette Stender, Gertrude Kent, Ellen Hopkins, Brian Smith, Anita Nicholson, Nancy Roy, Brenda Homsted, Cindy Downs, Cathy S Ross, Jeremiah Brown, and Northern New England Cardiovascular Disease Study Group

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Social Media in Nurse Anesthesia: A Model of a Reproducible Educational Podcast., Kristin Andrejco, Jon Lowrance, Brad Morgan, Cassidy Padgett, and Shawn Collins

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The effect of anticoagulation on bleeding-related complications following ureteroscopy., Mary E Westerman, Joseph A Scales, Vidit Sharma, Derek J Gearman, Johann P Ingimarsson, and Amy E Krambeck

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Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity., Zhaofei Wu, M Elena Martinez, Donald L St Germain, and Arturo Hernandez

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Valproate for agitation in critically ill patients: a retrospective study., David J. Gagnon, Gabriel V Fontaine, Kathryn E. Smith, Richard R. Riker, Russell R Miller, Patricia A. Lerwick, F L. Lucas, John T. Dziodzio, Kristen C. Sihler, and Gilles L. Fraser

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Vitamin D intake and the risk of incident kidney stones., Pietro Manuel Ferraro, Eric N. Taylor, Giovanni Gambaro, and Gary C Curhan

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Integrating GWAS and co-expression network data identifies bone mineral density genes SPTBN1 and MARK3 and an osteoblast functional module., Gina M Calabrese, Larry D Mesner, Joseph P Stains, Steven M Tommasini, Mark C Horowitz, Clifford J Rosen, and Charles R Farber

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Dyslipidemia: Current Therapies And Guidelines For Treatment, Edward T. Carreras and Donna M. Polk

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Parent vessel occlusion for treatment of cerebral aneurysms: Is there still an indication? A series of 17 patients., Nishant Ganesh Kumar, Travis R Ladner, Imad S Kahn, Scott L Zuckerman, Christopher B Baker, Deborah Cushing, Matthew R Sanborn, J Mocco, and Robert D Ecker

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Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy., Timothy P Fitzgibbons, Yvonne J K Edwards, Peter Shaw, Aline Iskandar, Mohamed Ahmed, Josiah Bote, Tejen Shah, Sumita Sinha, Robert E Gerszten, John F Keaney, Michael R Zile, and Gerard P Aurigemma

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Airway management and mechanical ventilation in acute brain injury., D B Seder and J Bösel

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An Investigation of the Relationship Between Emergency Medicine Trainee Burnout and Clinical Performance in a High-fidelity Simulation Environment., Dave W Lu, Scott M Dresden, D Mark Courtney, and David H Salzman

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A Quality Improvement Program to Reduce Potential Overtreatment of Diabetes Among Veterans at High Risk of Hypoglycemia., Versha G. Vimalandanda, Kristine DeSotto, TeChieh Chen, Jenny Mullakary, James Schlosser, Cliona Archambeault, Jordan Peck, Hannah Cassidy, Paul R. Conlin, Stewart Evans, Mark McConnell, and Eric Shirley

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Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature., Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, and Christine M Sorenson

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Can creating a Behavioral Task Force on the medical and surgical floor increase staff satisfaction rates?, Amy Lee

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Corrigendum: Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men., Daniel Price, Debra Burris, Anna Cloutier, Carol B Thompson, James K Rilling, and Richmond R Thompson

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Development of a Traumatic Brain Injury (TBI) Order Set at Maine Medical Center, Sarah Bockian, Emily Esslinger, and Martha Weatherhead

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Development of a Traumatic Brain Injury (TBI) Order Set at Maine Medical Center, Sarah Bockian, Emily Esslinger, and Martha Weatherhead

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Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest)., Rea P Anunciado-Koza, Justin Manuel, Randall L Mynatt, Jingying Zhang, Leslie P Kozak, and Robert A Koza

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Does medication safety and diversion education improve medication securement practices in SCU compared to current practice?, Natasha Stankiewicz

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Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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First-trimester chorionic bump--association with fetal aneuploidy in a high-risk population., Joseph R Wax, Angelina Cartin, Christian Litton, Michael G Pinette, and F L Lucas

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Growth factor regulation in the nephrogenic zone of the developing kidney., Leif Oxburgh, Sree Deepthi Muthukrishnan, and Aaron Brown

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Increased number of circulating CD8/CD26 T cells in the blood of Duchenne muscular dystrophy patients is associated with augmented binding of adenosine deaminase and higher muscular strength scores., Jonathan H Soslow, Larry W Markham, W Bryan Burnette, Cristi L Galindo, Igor Feoktistov, Frank J Raucci, Bruce M Damon, Douglas B. Sawyer, and Sergey Ryzhov

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In reply to Hauswald., Samir A Haydar, Tania D Strout, and Michael R Baumann

Introduction: Cognition, Rarely Discussed., John J. Compbell III

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Is feedback to medical learners associated with characteristics of improved patient care?, Victoria Hayes, Robert Bing-You, Kalli Varaklis, Robert Trowbridge, Heather Kemp, and Dina McKelvy

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Is trucking along enough? An exploration of mid-career nurses’ satisfaction, Heather Docherty

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Liberation From Mechanical Ventilation in Critically Ill Adults: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline: Inspiratory Pressure Augmentation During Spontaneous Breathing Trials, Protocols Minimizing Sedation, and Noninvasive Ventilation Immediately After Extubation., Daniel R Ouellette, Sheena Patel, Timothy D Girard, Peter E Morris, Gregory A Schmidt, Jonathon D Truwit, Waleed Alhazzani, Suzanne M Burns, Scott K Epstein, Andres Esteban, Eddy Fan, Miguel Ferrer, Gilles L Fraser, Michelle Ng Gong, Catherine L Hough, Sangeeta Mehta, Rahul Nanchal, Amy J Pawlik, William D Schweickert, Curtis N Sessler, Thomas Strøm, and John P Kress

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Liberation From Mechanical Ventilation in Critically Ill Adults: Executive Summary of an Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline., Gregory A Schmidt, Timothy D Girard, John P Kress, Peter E Morris, Daniel R Ouellette, Waleed Alhazzani, Suzanne M Burns, Scott K Epstein, Andres Esteban, Eddy Fan, Miguel Ferrer, Gilles L Fraser, Michelle Ng Gong, Catherine L Hough, Sangeeta Mehta, Rahul Nanchal, Sheena Patel, Amy J Pawlik, William D Schweickert, Curtis N Sessler, Thomas Strøm, Kevin C Wilson, and Jonathon D Truwit

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Maine Medical Center Research Institute: 2017 Year in Review, Maine Medical Center Research Institute

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Medical humanities: Using MedHum to promote the goal of professional identity in UME, Michael P.H. Stanley

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Optimal Timing From Myocardial Infarction to Coronary Artery Bypass Grafting on Hospital Mortality., Elizabeth L Nichols, Jock N McCullough, Cathy S Ross, Robert S Kramer, Benjamin M Westbrook, John D Klemperer, Bruce J Leavitt, Jeremiah R Brown, Elaine Olmstead, Felix Hernandez, Gerald L Sardella, Carmine Frumiento, David Malenka, Anthony DiScipio, and Northern New England Cardiovascular Disease Study Group

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Predicting mortality of ruptured abdominal aortic aneurysms in the era of endovascular repair., Christopher T Healey, Michael Neilson, David Clark, Andres Schanzer, William Robinson, and Vascular Study Group of New England None

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Predictors of recurrent hospital admission for patients presenting with diabetic ketoacidosis and hyperglycemic hyperosmolar state., Annabel L Bradford, Courtney Champagne Crider, Xizheng Xu, and Syed Hasan Naqvi

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Statistical Forecasting Models Used to Predict Daily Patient Volumes in the Emergency Department: A Proposal for a Systematic Review, Jon White

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Stroke and myocardial infarction following bronchial artery embolization in a cystic fibrosis patient., Matt Hoffman, Joseph P Gerding, and Jonathan B Zuckerman

The bioengineering core, Michaela Reagan

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What are the barriers and facilitators to Nurses’ utilization of a Nurse Driven Protocol (NDP) for Indwelling Urinary Catheter (IUC) removal?, Brenda Clark

Submissions from 2016

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IDH2 mutations define a unique subtype of breast cancer with altered nuclear polarity., Sarah Chiang, Britta Weigelt, Huei-Chi Wen, Fresia Pareja, Ashwini Raghavendra, Luciano G Martelotto, Kathleen A Burke, Thais Basili, Anqi Li, Felipe C Geyer, Salvatore Piscuoglio, Charlotte K Y Ng, Achim A Jungbluth, Jörg Balss, Stefan Pusch, Gabrielle M Baker, Kimberly S Cole, Andreas von Deimling, Julie M Batten, Jonathan D Marotti, Hwei-Choo Soh, Benjamin L McCalip, Jonathan Serrano, Raymond S Lim, Kalliopi P Siziopikou, Song Lu, Xiaolong Liu, Tarek Hammour, Edi Brogi, Matija Snuderl, A John Iafrate, Jorge S Reis-Filho, and Stuart J Schnitt

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Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates., Martin L Basch, Rogers M Brown, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Renée K Edlund, Hongyuan Zhang, Christine R Norton, Thomas Gridley, Susan E Cole, Angelika Doetzlhofer, Mirjana Maletic-Savatic, Neil Segil, and Andrew K Groves

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Adverse reaction to metal debris with concomitant incidental crystalline arthropathy in hip arthroplasty., Edward J Testa and Brian J. McGrory

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American Telemedicine Association guidelines for TeleICU operations., Theresa M Davis, Connie Barden, Steve Dean, Amnon Gavish, Irene Goliash, Susan Goran, Andrew Graley, Pat Herr, William Jackson, Edward Loo, James P Marcin, John Morgan Morris, David E Morledge, Carol Olff, Teresa Rincon, Stephanie Rogers, Herb Rogove, Rebecca Rufo, Elizabeth Thomas, Marc T Zubrow, Elizabeth A Krupinski, and Jordana Bernard

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A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure., Daniel J Lenihan, Sarah A Anderson, Carrie Geisberg Lenneman, Evan Brittain, James A S Muldowney, Lisa Mendes, Ping Z Zhao, Jennifer Iaci, Stephen Frohwein, Ronald Zolty, Andrew Eisen, Douglas B Sawyer, and Anthony O Caggiano

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Circulating vascular endothelial growth factor and the risk of cardiovascular events., Bernhard M Kaess, Sarah R Preis, Alexa Beiser, Douglas B. Sawyer, Tai C Chen, Sudha Seshadri, and Ramachandran S Vasan

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Combined supine and prone imaging acquisition in cardiac SPECT: A turn for the better., Mylan C Cohen

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Conflicting health information: a critical research need., Delesha M Carpenter, Lorie L Geryk, Annie T Chen, Rebekah H Nagler, Nathan F Dieckmann, and Paul K J Han

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Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism., J Patrizia Stohn, M Elena Martinez, and Arturo Hernandez

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Development and evaluation of the "BRISK Scale," a brief observational measure of risk communication competence., Paul K J Han, Katherine Joekes, Greg Mills, Caitlin Gutheil, Kahsi Smith, Nancy E Cochran, and Glyn Elwyn

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Implementation of a simplistic bivalirudin-warfarin transition protocol Is associated with improved achievement of INR values within the therapeutic range., Amber R Rollins, Kathryn E Smith, and Wesley R Zemrak

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Intensive point-of-care ultrasound training with long-term follow-up in a cohort of Rwandan physicians., Patricia C Henwood, David C. Mackenzie, Joshua S Rempell, Emily Douglass, Damas Dukundane, Andrew S Liteplo, Megan M Leo, Alice F Murray, Samuel Vaillancourt, Anthony J Dean, Resa E Lewiss, Stephen Rulisa, Elizabeth Krebs, A K Raja Rao, Emmanuel Rudakemwa, Vincent Rusanganwa, Patrick Kyanmanywa, and Vicki E Noble

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New insights into bone marrow adipocytes: report from the first European meeting on bone marrow adiposity (BMA 2015)., Pierre Hardouin, Pierre J Marie, and Clifford J Rosen

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Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis., Kristopher J Swiger, Eitan A Friedman, Evan L Brittain, Kelsey A Tomasek, Shi Huang, Yan R Su, Douglas B Sawyer, and Daniel J Lenihan

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Pneumonia prevention in intubated patients given sucralfate versus proton-pump inhibitors and/or histamine II receptor blockers., Gene A Grindlinger, Sarah B Cairo, and Carole B Duperre

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The cost and outcome effectiveness of total hip replacement: technique choice and volume-output effects matter., Jonathan P Goldstein, George M. Babikian, Adam J. Rana, Johanna A. Mackenzie, and Andrew Millar

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Vitamin D deficiency - is there really a pandemic?, JoAnn E Manson, Patsy M Brannon, Clifford J Rosen, and Christine L Taylor

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A prospective randomized study of the efficacy of "Turning Point," an inpatient violence intervention program., Catherine Loveland-Jones, Lucas Ferrer, Scott Charles, Frederick Ramsey, Andrea van Zandt, Jill Volgraf, Thomas Santora, Abhijit Pathak, Jay Dujon, Lars Sjoholm, Joseph Rappold, and Amy Goldberg

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Closed mitral commissurotomy during pregnancy in East Africa., Robert Kramer, Reed Quinn, Agneta Odera, Robert Groom, Nancy Boulanger, Eric Gunnoe, and Russell White

Evidence-Based Interview Strategy for New Nurses., Kelly Strout, Jeff Nevers, Deborah Bachard, and Sarah P. Varney

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Gastroschisis in Uganda: opportunities for improved survival., Anne S Wesonga, Tamara N Fitzgerald, Ronald Kabuye, Samuel Kirunda, Monica Langer, Nasser Kakembo, Doruk Ozgediz, and John Sekabira

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Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14., Maria Elena Martinez, David F. Cox, Brian P. Youth, and Arturo Hernandez

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Prevalence and Risk Factors for Overweight and Obesity among HIV-Infected Adults in Dar es Salaam, Tanzania., Helen Semu, Rachel M Zack, Enju Liu, Ellen Hertzmark, Donna Spiegelman, Kevin Sztam, Claudia Hawkins, Guerino Chalamila, Aisa Muya, Hellen Siril, Ramadhani Mwiru, Deo Mtasiwa, and Wafaie Fawzi

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Regulation of glucose handling by the skeleton: insights from mouse and human studies., Jian-Min Liu, Clifford J Rosen, Patricia Ducy, Stavroula Kousteni, and Gerard Karsenty

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Relevance of Quality Measurement to Integrative Healthcare in the United States., James M Whedon, Molly Punzo, Regina Dehen, Martha Brown Menard, David Fogel, and Jennifer Olejownik

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Relevance of Quality Measurement to Integrative Healthcare in the United States., James M. Whedon, Molly Punzo, Regina Dehen, Martha Brown Menard, David Fogel, and Jennifer Olejownik

Spinal Cord Injury., Michael Abraham, Jason Brown, and Andrew D. Perron

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The evolving paradigm of individualized postresuscitation care after cardiac arrest., David B. Seder and Christine Lord

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The evolving paradigm of individualized postresuscitation care after cardiac arrest., David B Seder, Christine Lord, and David J Gagnon

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The Vascular Quality Initiative Cardiac Risk Index for prediction of myocardial infarction after vascular surgery., Daniel J Bertges, Dan Neal, Andres Schanzer, Salvatore T Scali, Philip P Goodney, Jens Eldrup-Jorgensen, and Jack L Cronenwett

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Transfer of acute care surgery patients in a rural state: a concerning trend., Brittany Misercola, Kristen Sihler, Molly Douglas, Stephen Ranney, and Jonathan Dreifus

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Type 2 diabetes and aging: a not so sweet scenario for bone., R Dhaliwal and C J Rosen

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Cardiac dysfunction due to cancer therapy: finding new directions., Sergey Ryzhov, Sanjeev Francis, and Douglas B Sawyer

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Building better bones with biologics - a new approach to osteoporosis?, Clifford J Rosen and Julie R Ingelfinger

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Dietary protein and potassium, diet-dependent net acid load, and risk of incident kidney stones., Pietro Manuel Ferraro, Ernest I Mandel, Gary C Curhan, Giovanni Gambaro, and Eric N. Taylor

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Development of the Emotion Dysregulation Inventory: a PROMIS®ing method for creating sensitive and unbiased questionnaires for autism spectrum disorder., Carla A Mazefsky, Taylor N Day, Matthew Siegel, Susan W White, Lan Yu, and Paul A Pilkonis

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131 Community Naloxone Distribution in a Largely Rural State: Impact of Legislation and Challenges Faced., C Swinburne, J M. Sholl, and T D. Strout

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Accuracy and Reliability of Gastric Ultrasound for Stomach Contents., D C. Mckenzie, A Azad, V E. Noble, and A S. Liteplo

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Alcohol Consumption in Ugandan HIV-Infected Household-Brewers Versus Non-Brewers., Kinna Thakarar, Stephen B Asiimwe, Debbie M Cheng, Leah Forman, Christine Ngabirano, Winnie R Muyindike, Nneka I Emenyonu, Jeffrey H Samet, and Judith A Hahn

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Characterization of fatty acid composition in bone marrow fluid from postmenopausal women: modification after hip fracture., Melissa Miranda, Ana María Pino, Karen Fuenzalida, Clifford J. Rosen, Germán Seitz, and J Pablo Rodríguez

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CPR in Whitewater Drowning Victims: Is it Possible to Perform Adequate Chest Compressions Through a Personal Flotation Device?, S McCorvey, M Caudell, E Lurie, and R D'Zio

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Haematoma expansion and vitamin K antagonist reversal., Wesley R. Zemrak, Kathryn E. Smith, David J. Gagnon, Stephen S. Rolfe, and David B. Seder