Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2017

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Increased number of circulating CD8/CD26 T cells in the blood of Duchenne muscular dystrophy patients is associated with augmented binding of adenosine deaminase and higher muscular strength scores., Jonathan H Soslow, Larry W Markham, W Bryan Burnette, Cristi L Galindo, Igor Feoktistov, Frank J Raucci, Bruce M Damon, Douglas B. Sawyer, and Sergey Ryzhov

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In reply to Hauswald., Samir A Haydar, Tania D Strout, and Michael R Baumann

Introduction: Cognition, Rarely Discussed., John J. Compbell III

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Is feedback to medical learners associated with characteristics of improved patient care?, Victoria Hayes, Robert Bing-You, Kalli Varaklis, Robert Trowbridge, Heather Kemp, and Dina McKelvy

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Is trucking along enough? An exploration of mid-career nurses’ satisfaction, Heather Docherty

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Liberation From Mechanical Ventilation in Critically Ill Adults: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline: Inspiratory Pressure Augmentation During Spontaneous Breathing Trials, Protocols Minimizing Sedation, and Noninvasive Ventilation Immediately After Extubation., Daniel R Ouellette, Sheena Patel, Timothy D Girard, Peter E Morris, Gregory A Schmidt, Jonathon D Truwit, Waleed Alhazzani, Suzanne M Burns, Scott K Epstein, Andres Esteban, Eddy Fan, Miguel Ferrer, Gilles L Fraser, Michelle Ng Gong, Catherine L Hough, Sangeeta Mehta, Rahul Nanchal, Amy J Pawlik, William D Schweickert, Curtis N Sessler, Thomas Strøm, and John P Kress

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Liberation From Mechanical Ventilation in Critically Ill Adults: Executive Summary of an Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline., Gregory A Schmidt, Timothy D Girard, John P Kress, Peter E Morris, Daniel R Ouellette, Waleed Alhazzani, Suzanne M Burns, Scott K Epstein, Andres Esteban, Eddy Fan, Miguel Ferrer, Gilles L Fraser, Michelle Ng Gong, Catherine L Hough, Sangeeta Mehta, Rahul Nanchal, Sheena Patel, Amy J Pawlik, William D Schweickert, Curtis N Sessler, Thomas Strøm, Kevin C Wilson, and Jonathon D Truwit

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Maine Medical Center Research Institute: 2017 Year in Review, Maine Medical Center Research Institute

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Medical humanities: Using MedHum to promote the goal of professional identity in UME, Michael P.H. Stanley

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Optimal Timing From Myocardial Infarction to Coronary Artery Bypass Grafting on Hospital Mortality., Elizabeth L Nichols, Jock N McCullough, Cathy S Ross, Robert S Kramer, Benjamin M Westbrook, John D Klemperer, Bruce J Leavitt, Jeremiah R Brown, Elaine Olmstead, Felix Hernandez, Gerald L Sardella, Carmine Frumiento, David Malenka, Anthony DiScipio, and Northern New England Cardiovascular Disease Study Group

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Predicting mortality of ruptured abdominal aortic aneurysms in the era of endovascular repair., Christopher T Healey, Michael Neilson, David Clark, Andres Schanzer, William Robinson, and Vascular Study Group of New England None

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Predictors of recurrent hospital admission for patients presenting with diabetic ketoacidosis and hyperglycemic hyperosmolar state., Annabel L Bradford, Courtney Champagne Crider, Xizheng Xu, and Syed Hasan Naqvi

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Statistical Forecasting Models Used to Predict Daily Patient Volumes in the Emergency Department: A Proposal for a Systematic Review, Jon White

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Stroke and myocardial infarction following bronchial artery embolization in a cystic fibrosis patient., Matt Hoffman, Joseph P Gerding, and Jonathan B Zuckerman

The bioengineering core, Michaela Reagan

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What are the barriers and facilitators to Nurses’ utilization of a Nurse Driven Protocol (NDP) for Indwelling Urinary Catheter (IUC) removal?, Brenda Clark

Submissions from 2016

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IDH2 mutations define a unique subtype of breast cancer with altered nuclear polarity., Sarah Chiang, Britta Weigelt, Huei-Chi Wen, Fresia Pareja, Ashwini Raghavendra, Luciano G Martelotto, Kathleen A Burke, Thais Basili, Anqi Li, Felipe C Geyer, Salvatore Piscuoglio, Charlotte K Y Ng, Achim A Jungbluth, Jörg Balss, Stefan Pusch, Gabrielle M Baker, Kimberly S Cole, Andreas von Deimling, Julie M Batten, Jonathan D Marotti, Hwei-Choo Soh, Benjamin L McCalip, Jonathan Serrano, Raymond S Lim, Kalliopi P Siziopikou, Song Lu, Xiaolong Liu, Tarek Hammour, Edi Brogi, Matija Snuderl, A John Iafrate, Jorge S Reis-Filho, and Stuart J Schnitt

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Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates., Martin L Basch, Rogers M Brown, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Renée K Edlund, Hongyuan Zhang, Christine R Norton, Thomas Gridley, Susan E Cole, Angelika Doetzlhofer, Mirjana Maletic-Savatic, Neil Segil, and Andrew K Groves

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Adverse reaction to metal debris with concomitant incidental crystalline arthropathy in hip arthroplasty., Edward J Testa and Brian J. McGrory

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American Telemedicine Association guidelines for TeleICU operations., Theresa M Davis, Connie Barden, Steve Dean, Amnon Gavish, Irene Goliash, Susan Goran, Andrew Graley, Pat Herr, William Jackson, Edward Loo, James P Marcin, John Morgan Morris, David E Morledge, Carol Olff, Teresa Rincon, Stephanie Rogers, Herb Rogove, Rebecca Rufo, Elizabeth Thomas, Marc T Zubrow, Elizabeth A Krupinski, and Jordana Bernard

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A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure., Daniel J Lenihan, Sarah A Anderson, Carrie Geisberg Lenneman, Evan Brittain, James A S Muldowney, Lisa Mendes, Ping Z Zhao, Jennifer Iaci, Stephen Frohwein, Ronald Zolty, Andrew Eisen, Douglas B Sawyer, and Anthony O Caggiano

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Circulating vascular endothelial growth factor and the risk of cardiovascular events., Bernhard M Kaess, Sarah R Preis, Alexa Beiser, Douglas B. Sawyer, Tai C Chen, Sudha Seshadri, and Ramachandran S Vasan

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Combined supine and prone imaging acquisition in cardiac SPECT: A turn for the better., Mylan C Cohen

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Conflicting health information: a critical research need., Delesha M Carpenter, Lorie L Geryk, Annie T Chen, Rebekah H Nagler, Nathan F Dieckmann, and Paul K J Han

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Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism., J Patrizia Stohn, M Elena Martinez, and Arturo Hernandez

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Development and evaluation of the "BRISK Scale," a brief observational measure of risk communication competence., Paul K J Han, Katherine Joekes, Greg Mills, Caitlin Gutheil, Kahsi Smith, Nancy E Cochran, and Glyn Elwyn

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Implementation of a simplistic bivalirudin-warfarin transition protocol Is associated with improved achievement of INR values within the therapeutic range., Amber R Rollins, Kathryn E Smith, and Wesley R Zemrak

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Intensive point-of-care ultrasound training with long-term follow-up in a cohort of Rwandan physicians., Patricia C Henwood, David C. Mackenzie, Joshua S Rempell, Emily Douglass, Damas Dukundane, Andrew S Liteplo, Megan M Leo, Alice F Murray, Samuel Vaillancourt, Anthony J Dean, Resa E Lewiss, Stephen Rulisa, Elizabeth Krebs, A K Raja Rao, Emmanuel Rudakemwa, Vincent Rusanganwa, Patrick Kyanmanywa, and Vicki E Noble

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New insights into bone marrow adipocytes: report from the first European meeting on bone marrow adiposity (BMA 2015)., Pierre Hardouin, Pierre J Marie, and Clifford J Rosen

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Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis., Kristopher J Swiger, Eitan A Friedman, Evan L Brittain, Kelsey A Tomasek, Shi Huang, Yan R Su, Douglas B Sawyer, and Daniel J Lenihan

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Pneumonia prevention in intubated patients given sucralfate versus proton-pump inhibitors and/or histamine II receptor blockers., Gene A Grindlinger, Sarah B Cairo, and Carole B Duperre

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The cost and outcome effectiveness of total hip replacement: technique choice and volume-output effects matter., Jonathan P Goldstein, George M. Babikian, Adam J. Rana, Johanna A. Mackenzie, and Andrew Millar

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Vitamin D deficiency - is there really a pandemic?, JoAnn E Manson, Patsy M Brannon, Clifford J Rosen, and Christine L Taylor

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A prospective randomized study of the efficacy of "Turning Point," an inpatient violence intervention program., Catherine Loveland-Jones, Lucas Ferrer, Scott Charles, Frederick Ramsey, Andrea van Zandt, Jill Volgraf, Thomas Santora, Abhijit Pathak, Jay Dujon, Lars Sjoholm, Joseph Rappold, and Amy Goldberg

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Closed mitral commissurotomy during pregnancy in East Africa., Robert Kramer, Reed Quinn, Agneta Odera, Robert Groom, Nancy Boulanger, Eric Gunnoe, and Russell White

Evidence-Based Interview Strategy for New Nurses., Kelly Strout, Jeff Nevers, Deborah Bachard, and Sarah P. Varney

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Gastroschisis in Uganda: opportunities for improved survival., Anne S Wesonga, Tamara N Fitzgerald, Ronald Kabuye, Samuel Kirunda, Monica Langer, Nasser Kakembo, Doruk Ozgediz, and John Sekabira

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Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14., Maria Elena Martinez, David F. Cox, Brian P. Youth, and Arturo Hernandez

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Prevalence and Risk Factors for Overweight and Obesity among HIV-Infected Adults in Dar es Salaam, Tanzania., Helen Semu, Rachel M Zack, Enju Liu, Ellen Hertzmark, Donna Spiegelman, Kevin Sztam, Claudia Hawkins, Guerino Chalamila, Aisa Muya, Hellen Siril, Ramadhani Mwiru, Deo Mtasiwa, and Wafaie Fawzi

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Regulation of glucose handling by the skeleton: insights from mouse and human studies., Jian-Min Liu, Clifford J Rosen, Patricia Ducy, Stavroula Kousteni, and Gerard Karsenty

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Relevance of Quality Measurement to Integrative Healthcare in the United States., James M Whedon, Molly Punzo, Regina Dehen, Martha Brown Menard, David Fogel, and Jennifer Olejownik

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Relevance of Quality Measurement to Integrative Healthcare in the United States., James M. Whedon, Molly Punzo, Regina Dehen, Martha Brown Menard, David Fogel, and Jennifer Olejownik

Spinal Cord Injury., Michael Abraham, Jason Brown, and Andrew D. Perron

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The evolving paradigm of individualized postresuscitation care after cardiac arrest., David B. Seder and Christine Lord

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The evolving paradigm of individualized postresuscitation care after cardiac arrest., David B Seder, Christine Lord, and David J Gagnon

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The Vascular Quality Initiative Cardiac Risk Index for prediction of myocardial infarction after vascular surgery., Daniel J Bertges, Dan Neal, Andres Schanzer, Salvatore T Scali, Philip P Goodney, Jens Eldrup-Jorgensen, and Jack L Cronenwett

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Transfer of acute care surgery patients in a rural state: a concerning trend., Brittany Misercola, Kristen Sihler, Molly Douglas, Stephen Ranney, and Jonathan Dreifus

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Type 2 diabetes and aging: a not so sweet scenario for bone., R Dhaliwal and C J Rosen

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Cardiac dysfunction due to cancer therapy: finding new directions., Sergey Ryzhov, Sanjeev Francis, and Douglas B Sawyer

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Building better bones with biologics - a new approach to osteoporosis?, Clifford J Rosen and Julie R Ingelfinger

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Dietary protein and potassium, diet-dependent net acid load, and risk of incident kidney stones., Pietro Manuel Ferraro, Ernest I Mandel, Gary C Curhan, Giovanni Gambaro, and Eric N. Taylor

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Development of the Emotion Dysregulation Inventory: a PROMIS®ing method for creating sensitive and unbiased questionnaires for autism spectrum disorder., Carla A Mazefsky, Taylor N Day, Matthew Siegel, Susan W White, Lan Yu, and Paul A Pilkonis

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131 Community Naloxone Distribution in a Largely Rural State: Impact of Legislation and Challenges Faced., C Swinburne, J M. Sholl, and T D. Strout

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Accuracy and Reliability of Gastric Ultrasound for Stomach Contents., D C. Mckenzie, A Azad, V E. Noble, and A S. Liteplo

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Alcohol Consumption in Ugandan HIV-Infected Household-Brewers Versus Non-Brewers., Kinna Thakarar, Stephen B Asiimwe, Debbie M Cheng, Leah Forman, Christine Ngabirano, Winnie R Muyindike, Nneka I Emenyonu, Jeffrey H Samet, and Judith A Hahn

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Characterization of fatty acid composition in bone marrow fluid from postmenopausal women: modification after hip fracture., Melissa Miranda, Ana María Pino, Karen Fuenzalida, Clifford J. Rosen, Germán Seitz, and J Pablo Rodríguez

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CPR in Whitewater Drowning Victims: Is it Possible to Perform Adequate Chest Compressions Through a Personal Flotation Device?, S McCorvey, M Caudell, E Lurie, and R D'Zio

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Haematoma expansion and vitamin K antagonist reversal., Wesley R. Zemrak, Kathryn E. Smith, David J. Gagnon, Stephen S. Rolfe, and David B. Seder

Implementation of a COPD inpatient clinical pathway with a dedicated respiratory therapist team., Sally Brewer, Sally Whitten, and John Dziodzio

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Intended and unintended consequences of constraining clinician prescribing: the case of antipsychotics., John W Devlin, Pamela Smithburger, Jason M Kane, Gilles L. Fraser, and Yoanna Skrobik

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Inter-rater reliability of the APD, SFU and UTD grading systems in fetal sonography and MRI., D J. Chalmers, M L Meyers, K E Brodie, C Palmer, and J B Campbell

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Personalized prediction of psychosis: external validation of the NAPLS-2 psychosis risk calculator with the EDIPPP Project., Ricardo E Carrión, Barbara A Cornblatt, Cynthia Z Burton, Ivy F Tso, Andrea M Auther, Steven Adelsheim, Roderick Calkins, Cameron S Carter, Tara Niendam, Tamara G Sale, Stephan F Taylor, and William R. McFarlane

Photo Quiz 360®. Last Issue's Answer: Sweet Syndrome., Katherine G. Garlo, Nicholas Perros, Robert Smith, and Katy Linskey

Phot Quiz 360. New Rash and Fever in a Woman With Inflammatory Bowel Disease., Katherine G. Garlo, Nicholas Perros, Robert Smith, and Katy Linskey

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Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss., U T Iwaniec, K A Philbrick, C P Wong, J L Gordon, A M Kahler-Quesada, D A Olson, A J Branscum, J L Sargent, V E DeMambro, C J Rosen, and R T Turner

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Sedation quality in intensive care: which interventions work?, Richard R. Riker and Gilles L. Fraser

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Sef Regulates Epithelial-Mesenchymal Transition in Breast Cancer Cells., Qing He, Yan Gong, Lindsey Gower, Xuehui Yang, and Robert E Friesel

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Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study., Geoffrey Buckle, Louise Maranda, Jodi Skiles, John Michael Ong'echa, Joslyn Foley, Mara Epstein, Terry A Vik, Andrew Schroeder, Jennifer Lemberger, Alan Rosmarin, Scot C Remick, Jeffrey A Bailey, John Vulule, Juliana A Otieno, and Ann M Moormann

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Abdominal adipose tissue in MGUS and multiple myeloma., Joyce Veld, Elizabeth K O'Donnell, Michaela R. Reagan, Andrew J Yee, Martin Torriani, Clifford J. Rosen, and Miriam A Bredella

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A case of possible iatrogenic ketamine-Induced mania in a patient being treated for postoperative pain., Stephanie D. Nichols, Maya Bulman, Annya Tisher, and John J. Campbell

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Collaborative care and integration: changing roles and changing Identity of the child and adolescent psychiatrist?, Sandra L. Fritsch, Abigail Schlesinger, Amy D Habeger, Barry Sarvet, and Joyce N Harrison

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Decompressive craniectomy for severe traumatic brain injury: clinical study, literature review and meta-analysis., Gene A. Grindlinger, David H. Skavdahl, Robert D. Ecker, and Matthew R. Sanborn

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Family Interventions for Schizophrenia and the Psychoses: A Review., William R McFarlane

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Family Interventions for Schizophrenia and the Psychoses: A Review., William R. McFarlane

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From Guidelines to Practice: How Do Clinical Practice Standards Align with Established Recommendations for Duration of Parenteral Nutrition Therapy?, S Tate, M Creech, and L Tate

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Geographic access to interventional cardiology services in one rural state., James P Rhudy, Anne W Alexandrov, Kristiina E Hyrkäs, Rita A Jablonski-Jaudon, Erica R Pryor, Henry E Wang, and Marie A Bakitas

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How to implement alternative payment models in your total joint arthroplasty practice., Adam J. Rana

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HP1BP3 expression determines maternal behavior and offspring survival., B P Garfinkel, S Arad, S M Neuner, S Netser, S Wagner, C C Kaczorowski, C J. Rosen, M Gal, H Soreq, and J Orly

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Insights Into nephrolithiasis from the Nurses' Health Studies., Megan L Prochaska, Eric N. Taylor, and Gary C Curhan

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Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships With Mouse Adipose Tissues., Lucy Liaw, Igor Prudovsky, Robert A Koza, Rea V Anunciado-Koza, Matthew E Siviski, Volkhard Lindner, Robert E Friesel, Clifford J Rosen, Paul R S Baker, Brigitte Simons, and Calvin P H Vary

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Method of Meal Tray Delivery, Timing of Blood Glucose Testing and Insulin Administration. A Pilot Study., A T. Truong

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Narcotic Independence After Pancreatic Duct Stenting Predicts Narcotic Independence After Lateral Pancreaticojejunostomy for Chronic Pancreatitis., Richard S Kwon, Benjamin E Young, William F Marsteller, Christopher Lawrence, Bechien U Wu, Linda S Lee, Daniel Mullady, David A Klibansky, Timothy B Gardner, and Diane M Simeone

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Premeasured chordal loops for mitral valve repair., Marc Gillinov, Reed Quinn, Faraz Kerendi, Vince Gaudiani, Richard Shemin, Glenn Barnhart, Edward Raines, Marc W Gerdisch, and Michael Banbury

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Shared decision-making as an existential journey: aiming for restored autonomous capacity., Pål Gulbrandsen, Marla L Clayman, Mary Catherine Beach, Paul K. Han, Emily F Boss, Eirik H Ofstad, and Glyn Elwyn

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The chorionic bump: etiologic insights from two pathologic pregnancies., Joseph R. Wax, Hagen Blaszyk, Michael Jones, Angelina Cartin, and Michael G. Pinette

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The effect of a 4-hour moderate and 1-hour intense exercise session versus resting condition on luteinizing hormone (LH) level, variation, and pulsatility in six healthy male subjects., J L. Chiang, M P. Leondires, Wendy Craig, F L. Lucas, and D I. Spratt

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The health and libraries of public use retrospective study (HeLPURS)., Sam Zager, Amy Haskins, Katherine Maland, and Christina Holt

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AAOS Clinical Practice Guideline: Surgical Management of Osteoarthritis of the Knee: evidence-based guideline., Kristy L Weber, David S Jevsevar, and Brian J. McGrory

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A blown pupil and intracranial hemorrhage in a 4-week-old: a case of delayed onset vitamin K deficiency bleeding, a rare "can't miss" diagnosis., Ryley Enz and Robert S. Anderson Jr

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A dimeric peptide with erythropoiesis-stimulating activity uniquely affects erythropoietin receptor ligation and cell surface expression., Rakesh Verma, Jennifer M Green, Peter J Schatz, and Don M Wojchowski

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Assessing patients' experiences with communication across the cancer care continuum., Kathleen M Mazor, Richard L Street, Valerie M Sue, Andrew E Williams, Borsika A Rabin, and Neeraj K Arora

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Clinical and research considerations for patients with hypertensive acute heart failure: a consensus statement from the Society for Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group., Sean P Collins, Phillip D Levy, Jennifer L Martindale, Mark E Dunlap, Alan B Storrow, Peter S Pang, Nancy M Albert, G Michael Felker, Gregory J Fermann, Gregg C Fonarow, Michael M Givertz, Judd E Hollander, David E Lanfear, Daniel J Lenihan, JoAnn M Lindenfeld, W Frank Peacock, Douglas B. Sawyer, John R Teerlink, and Javed Butler

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Clinical and research considerations for patients with hypertensive acute heart failure: a consensus statement from the Society of Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group., Sean P Collins, Phillip D Levy, Jennifer L Martindale, Mark E Dunlap, Alan B Storrow, Peter S Pang, Nancy M Albert, G Michael Felker, Gregory J Fermann, Gregg C Fonarow, Michael M Givertz, Judd E Hollander, David J Lanfear, Daniel J Lenihan, JoAnn M Lindenfeld, W Frank Peacock, Douglas B. Sawyer, John R Teerlink, and Javed Butler

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Determinants of cancer screening in Asian-Americans., Quoc-Dien Trinh, Hanhan Li, Christian P Meyer, Julian Hanske, Toni K Choueiri, Gally Reznor, Stuart R Lipsitz, Adam S Kibel, Paul K. Han, Paul L Nguyen, Mani Menon, and Jesse D Sammon

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Factors Affecting Physicians' Intentions to Communicate Personalized Prognostic Information to Cancer Patients at the End of Life: An Experimental Vignette Study., Paul K J Han, Nathan F Dieckmann, Christina Holt, Caitlin Gutheil, and Ellen Peters

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Free serum valproate concentration more reliable than total concentration in critically ill patients., Colman Hatton, Richard R. Riker, David J. Gagnon, Teresa May, David B. Seder, and Gilles L. Fraser

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Health literacy-listening skill and patient questions following cancer prevention and screening discussions., Kathleen M Mazor, Donald L Rubin, Douglas W Roblin, Andrew E Williams, Paul K J Han, Bridget Gaglio, Sarah L Cutrona, Mary E Costanza, and Joann L Wagner

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Holmium laser for the surgical treatment of benign prostatic hyperplasia., Portia Thurmond, Sanchita Bose, and Lori B Lerner

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Managing the patient with pulmonary hypertension: specialty care centers, coordinated care, and patient support., Murali M Chakinala, Maribeth Duncan, and Joel Wirth

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Maternal Antiretroviral Therapy Is Associated with Lower Risk of Diarrhea in Early Childhood., Kevin A Sztam, Enju Liu, Karim P Manji, Roland Kupka, Rodrick Kisenge, Said Aboud, Wafaie W Fawzi, Ronald J Bosch, and Christopher P Duggan