Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2018

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Stress and symptoms of depression in fathers of infants admitted to the NICU., Helen Cyr-Alves, Lynn Macken, and Kristiina Hyrkas

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Stroke distribution patterns and characteristics in Kenya's leading public health tertiary institutions: Kenyatta National Hospital and Moi Teaching and Referral Hospital., Lydia Kaduka, Anne Korir, Chrispine Owuor Oduor, Judith Kwasa, Jane Mbui, Sylvanos Wabwire, Robai Gakunga, Nathan Okerosi, Yvonne Opanga, Isaac Kisiang'ani, Mercy Rotich Chepkurui, Erastus Muniu, and Scot C Remick

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The effect of high-dose atorvastatin on neural activity and cognitive function., Beth A Taylor, Alecia D Dager, Gregory A Panza, Amanda L Zaleski, Shashwath Meda, Gregory Book, Michael C Stevens, Sarah Tartar, C Michael White, Donna M Polk, Godfrey D Pearlson, and Paul D Thompson

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Epitope-specific monoclonal antibodies to FSHβ increase bone mass., Yaoting Ji, Peng Liu, Tony Yuen, Shozeb Haider, Jiahuan He, Raquel Romero, Hao Chen, Madison Bloch, Se-Min Kim, Daria Lizneva, Lubna Munshi, Chunxue Zhou, Ping Lu, Jameel Iqbal, Zhen Cheng, Maria I New, Aaron J Hsueh, Zhuan Bian, Clifford J Rosen, Li Sun, and Mone Zaidi

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What resources are used in emergency departments in rural sub-Saharan Africa? A retrospective analysis of patient care in a district-level hospital in Uganda., Cindy Carol Bitter, Brian Rice, Usha Periyanayagam, Bradley Dreifuss, Heather Hammerstedt, Sara W Nelson, Mark Bisanzo, Samuel Maling, and Stacey Chamberlain

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Cumulative exposure to environmental pollutants during early pregnancy and reduced fetal growth: the Project Viva cohort., Lisa B Rokoff, Sheryl L Rifas-Shiman, Brent A Coull, Andres Cardenas, Antonia M Calafat, Xiaoyun Ye, Alexandros Gryparis, Joel Schwartz, Sharon K Sagiv, Diane R Gold, Emily Oken, and Abby F Fleisch

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3d Tissue Engineered In Vitro Models Of Cancer In Bone., Anna M Sitarski, Heather Fairfield, Carolyne Falank, and Michaela R Reagan

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A Quality Improvement Initiative to Increase Scoring Consistency and Accuracy of the Finnegan Tool: Challenges in Obtaining Reliable Assessments of Drug Withdrawal in Neonatal Abstinence Syndrome., Wendy Timpson, Cheryl Killoran, Louise Maranda, Alan Picarillo, and Elisabeth Bloch-Salisbury

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Clinical implications of bone marrow adiposity., A G Veldhuis-Vlug and C J Rosen

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Conceptual Considerations for Payment Bundling in Breast Reconstruction., Clifford C Sheckter, Shantanu N Razdan, Joseph J Disa, Babak J Mehrara, and Evan Matros

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Early life exposure to per- and polyfluoroalkyl substances and mid-childhood lipid and alanine aminotransferase levels., Ana M Mora, Abby F Fleisch, Sheryl L Rifas-Shiman, Jennifer A Woo Baidal, Larissa Pardo, Thomas F Webster, Antonia M Calafat, Xiaoyun Ye, Emily Oken, and Sharon K Sagiv

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Efficacy and efficiency of perioperative stellate ganglion blocks in cardiac surgery: a pilot study., Christopher W Connors, Wendy Craig, Scott A Buchanan, Justin M Poltak, James B Gagnon, and Craig S Curry

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ErbB2 promotes endothelial phenotype of human left ventricular epicardial highly proliferative cells (eHiPC)., Sergey Ryzhov, Michael P. Robich, Daniel J. Roberts, Amanda J. Favreau-Lessard, Sarah M. Peterson, Edward Jachimowicz, Rutwik Rath, Calvin P H Vary, Reed Quinn, Robert S. Kramer, and Douglas B. Sawyer

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Examination of the patient-focused impact of cancer telegenetics among a rural population: comparison with traditional in-person services., Nan M Solomons, Amanda E Lamb, Frances L Lucas, Eileen F McDonald, and Susan Miesfeldt

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High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice., Adriana Lelis Carvalho, Victoria E DeMambro, Anyonya R Guntur, Phuong Le, Kenichi Nagano, Roland Baron, Francisco José Albuquerque de Paula, and Katherine J Motyl

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Perinatal outcomes associated with isolated velamentous cord insertion in singleton and twin pregnancies., Joshua A Sinkin, Wendy Craig, Michael Jones, Michael G Pinette, and Joseph R Wax

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Psychiatric hospital treatment of youth with autism spectrum disorder in the United States: needs, outcomes, and policy., Kelly McGuire and Matthew Siegel

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Reply., Malte W Vetterlein, Jesse D Sammon, and Firas Abdollah

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Risk stratification in pediatric perforated appendicitis: Prospective correlation with outcomes and resource utilization., Yasmine Yousef, Fouad Youssef, Trish Dinh, Kartikey Pandya, Hayden Stagg, Michael Homsy, Robert Baird, Jean-Martin Laberge, Dan Poenaru, Pramod Puligandla, Kenneth Shaw, and Sherif Emil

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State-by-state variation in prostate-specific antigen screening trends following the 2011 United States Preventive Services Task Force panel update., Malte W Vetterlein, Deepansh Dalela, Jesse D Sammon, Patrick Karabon, Akshay Sood, Tarun Jindal, Christian P Meyer, Björn Löppenberg, Maxine Sun, Quoc-Dien Trinh, Mani Menon, and Firas Abdollah

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Tailored Rabbit Antithymocyte Globulin Induction Dosing for Kidney Transplantation., Namita Singh, Ana P Rossi, Marizela Savic, Ronald J Rubocki, Mark G Parker, and John P Vella

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The association between mortality and distance to treatment facility in patients with muscle invasive bladder cancer., Stephen Ryan, Emily C Serrell, Patrick Karabon, Gregory Mills, Moritz Hansen, Matthew Hayn, Mani Menon, Quoc-Dien Trinh, Firas Abdollah, and Jesse D Sammon

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The Right Answer., Jessica Hathaway

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The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis., Heather Fairfield, Carolyne Falank, Elizabeth Harris, Victoria Demambro, Michelle McDonald, Jessica A Pettitt, Sindhu T Mohanty, Peter Croucher, Ina Kramer, Michaela Kneissel, Clifford J Rosen, and Michaela R Reagan

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The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species., Anne H van der Spek, Kin Ki Jim, Aldona Karaczyn, Hermina C van Beeren, Mariëtte T Ackermans, Veerle M Darras, Christina M J E Vandenbroucke-Grauls, Arturo Hernandez, Matthijs C Brouwer, Eric Fliers, Diederik van de Beek, and Anita Boelen

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Pioglitazone prevents stroke in patients with a recent transient ischemic attack or ischemic stroke: a planned secondary analysis of the IRIS trial (Insulin Resistance Intervention After Stroke)., Shadi Yaghi, Karen L Furie, Catherine M Viscoli, Hooman Kamel, Mark Gorman, Jennifer Dearborn, Lawrence H Young, Silvio E Inzucchi, Anne M Lovejoy, Scott E Kasner, Robin Conwit, and Walter N Kernan

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Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney., Sree Deepthi Muthukrishnan, Sergey Ryzhov, Michele Karolak, and Leif Oxburgh

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Derivation and validation of the CREST model for very early prediction of circulatory etiology death in patients without ST-segment-elevation myocardial infarction after cardiac arrest., Karen E Bascom, John Dziodzio, Samip Vasaiwala, Michael Mooney, Nainesh Patel, John McPherson, Paul McMullan, Barbara Unger, Niklas Nielsen, Hans Friberg, Richard R Riker, Karl B Kern, Christine W Duarte, and David B Seder

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Isolation, Culture, and Differentiation of Bone Marrow Stromal Cells and Osteoclast Progenitors from Mice., David E Maridas, Elizabeth Rendina-Ruedy, Phuong T Le, and Clifford J Rosen

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A Prospective Look at the Link Between Frailty and Shoulder Function in Asymptomatic Elderly Individuals., Elspeth Kinnucan, Matthew T Molcjan, David M Wright, and Julie A Switzer

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Assessment of brain-derived neurotrophic factor and osteopontin in a healthy pediatric population., Joshua D Chew, Larry Markham, Holly M Smith, Yan Ru Su, Kelsey Tomasek, James C Slaughter, Douglas Sawyer, and Jonathan H Soslow

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Clinicians' perspectives on incidentally discovered silent brain infarcts - A qualitative study., Lester Y Leung, Paul K J Han, Christine Lundquist, Gene Weinstein, David E Thaler, and David M Kent

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Communication of Scientific Uncertainty about a Novel Pandemic Health Threat: Ambiguity Aversion and Its Mechanisms., Paul K J Han, Brian J Zikmund-Fisher, Christine W Duarte, Megan Knaus, Adam Black, Aaron M Scherer, and Angela Fagerlin

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Cost comparison by treatment arm and center-level variations in cost and inpatient days on the phase III high-risk B acute lymphoblastic leukemia trial AALL0232., Amanda M DiNofia, Alix E Seif, Meenakshi Devidas, Yimei Li, Matthew Hall, Yuan-Shung V Huang, Viviane Cahen, Stephen P Hunger, Naomi J Winick, William L Carroll, Brian T Fisher, Eric C. Larsen, and Richard Aplenc

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Current Practices of Concussion Management in Primary Care: A Survey: 3381 Board #: 250 June 2 9:30 AM - 11:00 AM...American College of Sports Medicine Annual Meeting, May 29-June 2, 2018, Minneapolis, Minnesota, William L. Patterson, Kristine Karlson, William Dexter, Deborah Johnson, Christina Holt, Ardis Olson, and Amy Haskins

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Diffusion-weighted imaging evidence of altered white matter development from late childhood to early adulthood in Autism Spectrum Disorder., Fikret Işık Karahanoğlu, Bengi Baran, Quynh Trang Huong Nguyen, Djalel-Eddine Meskaldji, Anastasia Yendiki, Mark Vangel, Susan L Santangelo, and Dara S Manoach

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Distance from Home to Research Center: A Barrier to In-Person Visits but Not Treatment Adherence in a Stroke Trial., Enrique C Leira, Catherine M Viscoli, Linnea A Polgreen, Mark Gorman, Walter N Kernan, and IRIS Trial Investigators

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Earthquake exposures and mental health outcomes in children and adolescents from Phulpingdanda village, Nepal: a cross-sectional study., Jessica S Schwind, Clara B Formby, Susan L Santangelo, Stephanie A Norman, Rebecca Brown, Rebecca Hoffman Frances, Elisabeth Koss, and Dibesh Karmacharya

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Effect of fluorouracil, leucovorin, and oxaliplatin with or without onartuzumab in epidermal growth factor receptor-2-negative, mesenchymal-epithelial transition-positive gastroesophageal adenocarcinoma: is it a real failure?, Jimmy T Efird, Charulata Jindal, Timothy Fitzgerald, and Tithi Biswas

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Effects of Advanced Cardiac Procedure Simulator Training on Learning and Performance in Cardiovascular Medicine Fellows., Michael N Young, Roshanak Markley, Troy Leo, Samuel Coffin, Mario A Davidson, Joseph Salloum, Lisa A Mendes, and Julie B Damp

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Effects of pioglitazone on cognitive function in patients with a recent ischaemic stroke or TIA: a report from the IRIS trial., Karen L Furie, Catherine M Viscoli, Mark Gorman, Gary A Ford, Lawrence H Young, Silvio E Inzucchi, Peter D Guarino, Anne M Lovejoy, Robin Conwit, David Tanne, and Walter N Kernan

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Expanding the neurodevelopmental phenotype of PURA syndrome., Bo Hoon Lee, Margot R F Reijnders, Oluwatobi Abubakare, Emily Tuttle, Brynn Lape, Kelly Q Minks, Christopher Stodgell, Loisa Bennetto, Jennifer Kwon, Chin-To Fong, Karen W Gripp, Eric D Marsh, Wendy E Smith, Ahm M Huq, Stephanie A Coury, Wen-Hann Tan, Orestes Solis, Rupal I Mehta, Richard J Leventer, Diana Baralle, David Hunt, and Alex R Paciorkowski

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External validation of a Rapid Ruptured Abdominal Aortic Aneurysm Score., Michael Neilson, Christopher Healey, David Clark, and Brian Nolan

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Free open access medical education (FOAM) resources in a team-based learning educational series., Timothy S. Fallon and Tania D. Strout

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From the psychosis prodrome to the first-episode of psychosis: no evidence of a cognitive decline., Ricardo E Carrión, Deborah J Walder, Andrea M Auther, Danielle McLaughlin, Heather O Zyla, Steven Adelsheim, Roderick Calkins, Cameron S Carter, Bentson McFarland, Ryan Melton, Tara Niendam, J Daniel Ragland, Tamara G Sale, Stephan F Taylor, William R McFarlane, and Barbara A Cornblatt

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Hip Injury - Soccer: 2676 June 1 4:15 PM - 4:35 PM...American College of Sports Medicine Annual Meeting, May 29-June 2, 2018, Minneapolis, Minnesota, James Alex and Heather Gillespie MD

Improving Time to Antibiotics for Pediatric Oncology Patients With Suspected Infections: An Emergency Department-Based Quality Improvement Intervention:., Yoshida Hiromi, Kasey J. Leger, Xu Min, Russell T. Migita, Joe C. Rutledge, Jessica A. Pollard, Leah Kroon, Suzan S. Mazor, Andres Moon, and Lori E. Rutman

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Increased aggression and lack of maternal behavior in Dio3-deficient mice are associated with abnormalities in oxytocin and vasopressin systems., J P Stohn, M E Martinez, M Zafer, D López-Espíndola, L M Keyes, and A Hernandez

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Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma., Danielle Harmer, Carolyne Falank, and Michaela R Reagan

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Intern as patient: a patient experience simulation to cultivate empathy in emergency medicine residents., Sara W. Nelson, Carl A. Germann, Casey Z. MacVane, Rebecca B. Bloch, Timothy S. Fallon, and Tania D. Strout

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Maine Medical Center Research Institute: 2018 Year in Review, Maine Medical Center Research Institute

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New anthropometric classification scheme of preoperative nutritional status in children: a retrospective observational cohort study., Anne Stey, Joni Ricks-Oddie, Sheila Innis, Shawn J Rangel, R Lawrence Moss, Bruce L Hall, Albert Dibbins, and Erik D Skarsgard

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New Bone Cell Type Identified as Driver of Drug Resistance in Multiple Myeloma: The Bone Marrow Adipocyte, Carolyne Falank, Heather Fairfield, Mariah Farrell, and Michaela Reagan

New Persistent Opioid Use After Minor and Major Surgical Procedures in U.S. Adults., Jean C. Hostage

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Phenylephrine infusion impact on surgical site infections after lower extremity bypass surgery., Craig Curry, Jens Eldrup-Jorgensen, Janelle Richard, Michele C Siciliano, and Wendy Craig

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Prenatal Exposure to Traffic Pollution and Childhood Body Mass Index Trajectory., Abby F Fleisch, Izzuddin M Aris, Sheryl L Rifas-Shiman, Brent A Coull, Heike Luttmann-Gibson, Petros Koutrakis, Joel D Schwartz, Itai Kloog, Diane R Gold, and Emily Oken

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Procedure-based postoperative risk prediction using NSQIP data., David E Clark, Timothy L Fitzgerald, and Albert W Dibbins

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Prostate cancer screening in early Medicaid expansion states., Jesse D Sammon, Emily C Serrell, Patrick Karabon, Jeffrey J Leow, Firas Abdollah, Joel S Weissman, Paul K J Han, Moritz Hansen, Mani Menon, and Quoc-Dien Trinh

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Reduced serum IGF-1 associated with hepatic osteodystrophy Is a main determinant of low cortical but not trabecular bone mass., Zhongbo Liu, Tianzhen Han, Haim Werner, Clifford J. Rosen, Mitchell B Schaffler, and Shoshana Yakar

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Shoulder Pain - Builder with Chronic Calcifications: 567 May 30 2:00 PM - 2:20 PM...ACSM 2018, American College of Sports Medicine Annual Meeting, May 29-June 2, 2018, Minneapolis, MN, USA., Lauren Nadkarni, Krystian Bigosinski, and Heather Gillespie MD

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Shoulder - Why So Weak? - Track And Field: 2133 June 1 10:10 AM - 10:30 AM...ACSM 2018, American College of Sports Medicine Annual Meeting, May 29-June 2, 2018, Minneapolis, MN, USA., William L. Patterson

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Soluble and Cell-Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma., Mariah L Farrell and Michaela R Reagan

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Stroke Mortality in Kenya's Public Tertiary Hospitals: A Prospective Facility-Based Study., Lydia Kaduka, Erastus Muniu, Chrispine Oduor, Jane Mbui, Robai Gakunga, Judith Kwasa, Sylvanus Wabwire, Nathan Okerosi, Anne Korir, and Scot Remick

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Successful rebuilding after disaster, even in the heart, starts with infrastructure., Michael P. Robich, Sergey Ryzhov, and Douglas B. Sawyer

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Thyroid hormone role and economy in the developing testis., Arturo Hernandez

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Treatment With a Ghrelin Agonist in Outpatient Women With Anorexia Nervosa: A Randomized Clinical Trial., Pouneh K Fazeli, Elizabeth A Lawson, Alexander T Faje, Kamryn T Eddy, Hang Lee, Fred T Fiedorek, Anne Breggia, Ildiko M Gaal, Rebecca DeSanti, and Anne Klibanski

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Use of ceftolozane-tazobactam in a cystic fibrosis patient with multidrug-resistant pseudomonas infection and renal insufficiency., Katie Stokem, Jonathan B Zuckerman, David P Nicolau, Minkey Wungwattana, and Edmund H Sears

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Using controlled substance receipt patterns to predict prescription overdose death., Christina T. Holt, Kenneth L. McCall, Gary Cattabriga, Chunhao Tu, Elenna K. Smalley, and Stephanie D. Nichols

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Variation in the use of active surveillance for low-risk prostate cancer., Björn Löppenberg, David F Friedlander, Anna Krasnova, Andrew Tam, Jeffrey J Leow, Paul L Nguyen, Hawa Barry, Stuart R Lipsitz, Mani Menon, Firas Abdollah, Jesse D. Sammon, Maxine Sun, Toni K Choueiri, Adam S Kibel, and Quoc-Dien Trinh

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Variations in institutional review board processes and consent requirements for trauma research: an EAST multicenter survey., Jeffry Nahmias, Areg Grigorian, Scott Brakenridge, Randeep S Jawa, Daniel N Holena, John Varujan Agapian, Brandon Bruns, Paul J Chestovich, Bruce Chung, Jonathan Nguyen, Carl I Schulman, Kristan Staudenmayer, Rachel Dixon, Jason W Smith, Andrew C Bernard, and Jose L Pascual

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Visual art in medical education, Kimberly Dao

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What's next for acute heart failure research?, Sean P Collins, Phillip D Levy, Gregory J Fermann, Michael M Givertz, Jennifer M Martindale, Peter S Pang, Alan B Storrow, Deborah D Diercks, G Michael Felker, Gregg C Fonarow, David J Lanfear, Daniel J Lenihan, JoAnn M Lindenfeld, W Frank Peacock, Douglas M. Sawyer, John R Teerlink, and Javed Butler

Submissions from 2017

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Data Cleaning in the Evaluation of a Multi-Site Intervention Project., Gavin Welch, Friedrich von Recklinghausen, Andreas Taenzer, Lucy Savitz, and Lisa Weiss

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Interhospital transfer before thrombectomy is associated with delayed treatment and worse outcome in the STRATIS registry (systematic evaluation of patients treated with neurothrombectomy devices for acute ischemic stroke)., Michael T Froehler, Jeffrey L Saver, Osama O Zaidat, Reza Jahan, Mohammad Ali Aziz-Sultan, Richard P Klucznik, Diogo C Haussen, Frank R Hellinger, Dileep R Yavagal, Tom L Yao, David S Liebeskind, Ashutosh P Jadhav, Rishi Gupta, Ameer E Hassan, Coleman O Martin, Hormozd Bozorgchami, Ritesh Kaushal, Raul G Nogueira, Ravi H Gandhi, Eric C Peterson, Shervin R Dashti, Curtis A Given, Brijesh P Mehta, Vivek Deshmukh, Sidney Starkman, Italo Linfante, Scott H McPherson, Peter Kvamme, Thomas J Grobelny, Muhammad S Hussain, Ike Thacker, Nirav Vora, Peng Roc Chen, Stephen J Monteith, Robert D. Ecker, Clemens M Schirmer, Eric Sauvageau, Alex Abou-Chebl, Colin P Derdeyn, Lucian Maidan, Aamir Badruddin, Adnan H Siddiqui, Travis M Dumont, Abdulnasser Alhajeri, M Asif Taqi, Khaled Asi, Jeffrey Carpenter, Alan Boulos, Gaurav Jindal, Ajit S Puri, Rohan Chitale, Eric M Deshaies, David H Robinson, David F Kallmes, Blaise W Baxter, Mouhammad A Jumaa, Peter Sunenshine, Aniel Majjhoo, Joey D English, Shuichi Suzuki, Richard D Fessler, Josser E Delgado Almandoz, Jerry C Martin, and Nils H Mueller-Kronast

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A perspective on malignancy in the marrow., Michaela R Reagan, Jane B Lian, Clifford J Rosen, and Gary S Stein

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A protocol for postoperative admission of elective craniotomy patients to a non-ICU or step-down setting., Jeffrey E Florman, Deborah Cushing, Lynne A Keller, and Anand I Rughani

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A retrospective analysis comparing oral stepdown therapy for enterobacteriaceae bloodstream infections: fluoroquinolones versus beta-lactams., Nicholas J. Mercuro, Patricia Stogsdill, and Minkey Wungwattana

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Chronic neuregulin-1β treatment mitigates the progression of postmyocardial infarction heart failure in the setting of Type 1 diabetes mellitus by suppressing myocardial apoptosis, fibrosis, and key oxidant-producing enzymes., Manisha Gupte, Hind Lal, Firdos Ahmad, Douglas B Sawyer, and Michael F Hill

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Clinical pitfalls in misoprostol-based medical management of first-trimester induced and presumed spontaneous abortion., Joseph R. Wax, Kelley Conroy, Michael G. Pinette, Christian Litton, and Angelina Cartin

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Cover image, volume 232, number 12, December 2017., Michaela R Reagan, Jane B Lian, Clifford J Rosen, and Gary S Stein

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Critical shoulder angle is associated with full-thickness rotator cuff tears in patients with glenohumeral osteoarthritis., Matthew T Mantell, Ryan Nelson, Jeremiah T Lowe, Donald P Endrizzi, and Andrew Jawa

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Desmoid tumours in children: when wait-and-see becomes wait-and-treat., Aaron Weiss and Douglas Hawkins

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High early major complication rate after revision for mechanically assisted crevice corrosion in metal-on-polyethylene total hip arthroplasty., Brian J McGrory and Anna H Jorgensen

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Low-dose prothrombin complex concentrate for warfarin-associated intracranial hemorrhage with INR less than 2.0., Wesley R Zemrak, Kathryn E Smith, Stephen S Rolfe, Teresa May, Robert L Trowbridge, Timothy L Hayes, Gene A Grindlinger, and David B Seder

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No consensus for femoral head impaction technique in surgeon education materials from orthopedic implant manufacturers., Brian J. McGrory and Eric Ng

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Pediatric patient-centered transitions from hospital to home: improving the discharge medication process., Leah A Mallory, Noah P Diminick, Jonathan P Bourque, Meredith R Bryden, Jessica L Miller, Nancy M Nystrom, Melanie R Lord, and Lorraine L McElwain

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Prostacyclin Therapy for Pulmonary Arterial Hypertension Evolves Again With the Development of an Implantable Delivery System., Joel A Wirth and Harold I Palevsky

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Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice., Phuong T Le, Kathleen A Bishop, David E Maridas, Katherine J Motyl, Daniel J Brooks, Kenichi Nagano, Roland Baron, Mary L Bouxsein, and Clifford J Rosen

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Standardization of care for pediatric perforated appendicitis improves outcomes., Yasmine Yousef, Fouad Youssef, Michael Homsy, Trish Dinh, Kartikey Pandya, Hayden Stagg, Robert Baird, Jean-Martin Laberge, Dan Poenaru, Pramod Puligandla, Kenneth Shaw, and Sherif Emil

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Streptococcus suis meningitis can require a prolonged treatment course., Jean Dejace, Patrick Bagley, and Emily Wood

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Structure and function of bone marrow adipocytes., Francisco José Albuquerque de Paula and Clifford J. Rosen

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The evolution of uncertainty in second opinions about prostate cancer treatment., Marij A Hillen, Caitlin M Gutheil, Ellen M A Smets, Moritz Hansen, Terrence M Kungel, Tania D Strout, and Paul K J Han

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The implementation of targeted temperature management: an evidence-based guideline from the Neurocritical Care Society., Lori Kennedy Madden, Michelle Hill, Teresa L May, Theresa Human, Mary McKenna Guanci, Judith Jacobi, Melissa V Moreda, and Neeraj Badjatia

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The use of prostate specific antigen screening in purchased versus direct care settings: data from the TRICARE® military database., Alexander P Cole, Wei Jiang, Stuart R Lipsitz, Peter A Learn, Maxine Sun, Toni K Choueiri, Paul L Nguyen, Adam S Kibel, Mani Menon, Jesse D Sammon, Tracey Koehlmoos, Adil Haider, and Quoc-Dien Trinh

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Tumor Treating Fields (TTFields)—A Novel Cancer Treatment Modality: Translating Preclinical Evidence and Engineering Into a Survival Benefit with Delayed Decline in Quality of Life., R Stupp, M Taphoorn, L Driven, S Taillibert, J Honnorat, T C. Chen, J Sroubek, S H. Paek, J B. Escuder, J Easwa, C David, C Kim, R Desai, A Olivi, Y Kew, A Hottinger, M E. Hegi, E Kirson, G Lavy-Shahaf, and Z Ram

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Unsaturation level decreased in bone marrow fat of postmenopausal women with low bone density using high resolution magic angle spinning (HRMAS)., Xiaojuan Li, Keerthi Shet, Kaipin Xu, Juan Pablo Rodríguez, Ana María Pino, John Kurhanewicz, Ann Schwartz, and Clifford J Rosen

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Variation in locoregional prostate cancer care and treatment trends at commission on cancer designated facilities: a national cancer data base analysis 2004 to 2013., Björn Löppenberg, Akshay Sood, Deepansh Dalela, Patrick Karabon, Jesse D Sammon, Malte W Vetterlein, Joachim Noldus, James O Peabody, Quoc-Dien Trinh, Mani Menon, and Firas Abdollah

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Cefepime-induced neurotoxicity: a systematic review., Lauren E Payne, David J Gagnon, Richard R Riker, David B Seder, Elizabeth K Glisic, Jane G Morris, and Gilles L Fraser

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Management of arthropod pathogen vectors in North America: minimizing adverse effects on pollinators., Howard S Ginsberg, Timothy A Bargar, Michelle L Hladik, and Charles Lubelczyk

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A three-talk model for shared decision making: multistage consultation process., Glyn Elwyn, Marie Anne Durand, Julia Song, Johanna Aarts, Paul J Barr, Zackary Berger, Nan Cochran, Dominick Frosch, Dariusz Galasiński, Pål Gulbrandsen, Paul K J Han, Martin Härter, Paul Kinnersley, Amy Lloyd, Manish Mishra, Lilisbeth Perestelo-Perez, Isabelle Scholl, Kounosuke Tomori, Lyndal Trevena, Holly O Witteman, and Trudy Van der Weijden