Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2016

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Growth of human breast tissues from patient cells in 3D hydrogel scaffolds., Ethan S Sokol, Daniel H Miller, Anne Breggia, Kevin C Spencer, Lisa M Arendt, and Piyush B Gupta

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Heterozygous caveolin-3 mice show increased susceptibility to palmitate-induced insulin resistance., M A Hassan Talukder, Marilena Preda, Larisa Ryzhova, Igor Prudovsky, and Ilka M Pinz

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Impact of a quality improvement program in interventional radiology (IR) on the incidence of central line-associated blood stream infections., T Brown and D Mittleider

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Improving Adherence to Cardiovascular Therapies: An Economic Evaluation of a Randomized Pragmatic Trial., David H Smith, Maureen O'Keeffe-Rosetti, Ashli A Owen-Smith, Cynthia Rand, Jeffrey Tom, Suma Vupputuri, Reesa Laws, Amy Waterbury, Dana D Hankerson-Dyson, Cyndee Yonehara, Andrew Williams, Jennifer Schneider, John F Dickerson, and William M Vollmer

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Inadequacy of Headache Management After Subarachnoid Hemorrhage., Elizabeth K Glisic, Linda Gardiner, Linda Josti, Elizabeth Dermanelian, Sandra Ridel, John Dziodzio, Barbara McCrum, Ben Enos, Patricia Lerwick, Gilles L Fraser, Paul Muscat, Richard R Riker, Robert Ecker, Jeffrey Florman, and David B Seder

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Isolated infrapopliteal arterial occlusive disease contributing to lower extremity tissue loss: quantitative pulse volume recording analysis compared to ankle brachial index in the evaluation of diabetic patients., D Hechavarria and D Mettleider

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Mortality in Children Under Five Receiving Nonphysician Clinician Emergency Care in Uganda., Brian Rice, Usha Periyanayagam, Stacey Chamberlain, Bradley Dreifuss, Heather Hammerstedt, Sara Nelson, Samuel Maling, and Mark Bisanzo

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Privacy versus care--The shifting balance in mental health., Mary Jean Mork, Steven Price, and Kathryn Best

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Qualitative Approaches Appropriate in Instrument Development for Children, Youths, and Family Members...28th Annual Scientific Session, June 2-6, 2017, Baltimore, Maryland, Judith Vessey, Rachel DiFazio, and Tania Strout

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Sustained Inhibition of Proliferative Response After Transient FGF Stimulation Is Mediated by Interleukin 1 Signaling., Ashleigh Poole, Doreen Kacer, Emily Cooper, Francesca Tarantini, and Igor Prudovsky

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The rheology of subarachnoid hemorrhage., Robert D Ecker

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The Type 3 Deiodinase Is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis., M Elena Martinez, Aldona Karaczyn, J Patrizia Stohn, William T Donnelly, Walburga Croteau, Robin P Peeters, Valerie A Galton, Douglas Forrest, Donald St Germain, and Arturo Hernandez

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Transgender Health in a Regional Emergency Department: Assessing Barriers to Care, Community Experiences, and Caregiver Preparedness to Create a Targeted Educational Intervention for Emergency Clinicians...28th Annual Scientific Session, June 2-6, 2017, Baltimore, Maryland., Tania Strout

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Weighty Problems: Predictors of Family Physicians Documenting Overweight and Obesity., Peggy R Cyr, Amy E Haskins, Christina Holt, and Jasmine Hanifi

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Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age., Jeff P Gorski, Nichole T Huffman, Julian Vallejo, Leticia Brotto, Sridar V Chittur, Anne Breggia, Amber Stern, Jian Huang, Chenglin Mo, Nabil G Seidah, Lynda Bonewald, and Marco Brotto

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Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release., Igor Prudovsky, Doreen Kacer, Julie Davis, Varun Shah, Srinivas Jayanthi, Isabelle Huber, Rajalingam Dakshinamurthy, Owen Ganter, Raffaella Soldi, David Neivandt, Olgun Guvench, and Thallapuranam Krishnaswamy Suresh Kumar

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Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Seth E Karol, Leonard A Mattano, Wenjian Yang, Kelly W Maloney, Colton Smith, ChengCheng Liu, Laura B Ramsey, Christian A Fernandez, Tamara Y Chang, Geoffrey Neale, Cheng Cheng, Elaine Mardis, Robert Fulton, Paul Scheet, F Anthony San Lucas, Eric C Larsen, Mignon L Loh, Elizabeth A Raetz, Stephen P Hunger, Meenakshi Devidas, and Mary V Relling

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DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH., Zhongbo Liu, Oran D Kennedy, Luis Cardoso, Jelena Basta-Pljakic, Nicola C Partridge, Mitchell B Schaffler, Clifford J Rosen, and Shoshana Yakar

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Electronic records, registries, and the development of "big data": crowd-sourcing quality toward knowledge., Summer B Dewdney and Jason Lachance

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Heart Rate and the Post Cardiac Arrest Syndrome: Another Clue to Individualizing Care?, Karen Bascom, Richard R Riker, and David B Seder

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Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification., Paolo Fusar-Poli, Marco Cappucciati, Stefan Borgwardt, Scott W Woods, Jean Addington, Barnaby Nelson, Dorien H Nieman, Daniel R Stahl, Grazia Rutigliano, Anita Riecher-Rössler, Andor E Simon, Masafumi Mizuno, Tae Young Lee, Jun Soo Kwon, May M L Lam, Jesus Perez, Szabolcs Keri, Paul Amminger, Sibylle Metzler, Wolfram Kawohl, Wulf Rössler, Jimmy Lee, Javier Labad, Tim Ziermans, Suk Kyoon An, Chen-Chung Liu, Kristen A Woodberry, Amel Braham, Cheryl Corcoran, Patrick McGorry, Alison R Yung, and Philip K McGuire

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Identification of an endogenously generated cryptic collagen epitope (XL313) that may selectively regulate angiogenesis by an integrin Yes-associated protein (YAP) mechano-transduction pathway, Jacquelyn J Ames, Liangru Contois, Jennifer M Caron, Eric Tweedie, Xuehui Yang, Robert Friesel, Calvin Vary, and Peter C Brooks

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Letter: Survival With Glioblastoma Multiforme and the Timing of Chemoradiation., Jeffrey E Florman, Devon L Evans, Christine Lu-Emerson, Deborah Cushing, and Anand Rughani

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Notch signal reception is required in vascular smooth muscle cells for ductus arteriosus closure., Luke T Krebs, Christine R Norton, and Thomas Gridley

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Passenger Gene Mutations: Unwanted Guests in Genetically Modified Mice., Cheryl L Ackert-Bicknell and Clifford J Rosen

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Pediatric Respiratory Emergencies., Amber M Richards

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Pediatric surgery as an essential component of global child health., Doruk Ozgediz, Monica Langer, Phyllis Kisa, and Dan Poenaru

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The Insertion and Management of External Ventricular Drains: An Evidence-Based Consensus Statement : A Statement for Healthcare Professionals from the Neurocritical Care Society., Herbert I Fried, Barnett R Nathan, A Shaun Rowe, Joseph M Zabramski, Norberto Andaluz, Adarsh Bhimraj, Mary McKenna Guanci, David B Seder, and Jeffrey M Singh

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Type 2 diabetes and the skeleton: new insights into sweet bones., Vikram V Shanbhogue, Deborah M Mitchell, Clifford J Rosen, and Mary L Bouxsein

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Increased myocardial native T1 and extracellular volume in patients with Duchenne muscular dystrophy., Jonathan H Soslow, Stephen M Damon, Kimberly Crum, Mark A Lawson, James C Slaughter, Meng Xu, Andrew E Arai, Douglas B Sawyer, David A Parra, Bruce M Damon, and Larry W Markham

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Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion., Yusuke Yamamoto, Xia Wang, Denis Bertrand, Florian Kern, Ting Zhang, Marcin Duleba, Supriya Srivastava, Chiea Chuen Khor, Yuanyu Hu, Lane H Wilson, Hagen Blaszyk, Daniil Rolshud, Ming Teh, Jianjun Liu, Brooke E Howitt, Matthew Vincent, Christopher P Crum, Niranjan Nagarajan, Khek Yu Ho, Frank McKeon, and Wa Xian

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CTHRC1 Receptor and Methods if Use Thereof, Maine Medical Center, Volkhard Lindner, Calvin P. Vary, and Julia P. Stohn

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AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes., Thomas H Trojian, Andrew L Concoff, Susan M Joy, John R Hatzenbuehler, Whitney J Saulsberry, and Craig I Coleman

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AMSSM Scientific Statement Concerning Viscosupplementation Injections for Knee Osteoarthritis: Importance for Individual Patient Outcomes., Thomas H Trojian, Andrew L Concoff, Susan M Joy, John R Hatzenbuehler, Whitney J Saulsberry, and Craig I Coleman

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Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways., Polina Sysa-Shah, Carlo G Tocchetti, Manveen Gupta, Peter P Rainer, Xiaoxu Shen, Byung-Hak Kang, Frances Belmonte, Jian Li, Yi Xu, Xin Guo, Djahida Bedja, Wei Dong Gao, Nazareno Paolocci, Rutwik Rath, Douglas B Sawyer, Sathyamangla V Naga Prasad, and Kathleen Gabrielson

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Chapter: Uncertainty and ambiguity in health decisions., Paul K. Han

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Clinafloxacin for treatment of Burkholderia cenocepacia infection in a cystic fibrosis patient, Akshu Balwan, David P Nicolau, Minkey Wungwattana, Jonathan B Zuckerman, and Valerie Waters

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Colorectal carcinoma in pediatric patients: A comparison with adult tumors, treatment and outcomes from the National Cancer Database., Gabriela C Poles, David E Clark, Sara W Mayo, Elizabeth A Beierle, Melanie Goldfarb, Kenneth W Gow, Adam Goldin, John J Doski, Jed G Nuchtern, Sanjeev A Vasudevan, and Monica Langer

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Combined volume reduction with the loop-and-leave technique permits safe endoscopic management of high-risk giant gastric polyps., John Walker, Douglas A Howell, Suraj Gupta, Joshua Penfield, and David A Klibansky

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Discovery of novel small molecule inhibitors of VEGF expression in tumor cells using a cell-based high throughput screening platform., Liangxian Cao, Marla Weetall, Jenelle Bombard, Hongyan Qi, Tamil Arasu, William Lennox, Jean Hedrick, Josephine Sheedy, Nicole Risher, Peter C Brooks, Panayiota Trifillis, Christopher Trotta, Young-Choon Moon, John Babiak, Neil G Almstead, Joseph M Colacino, Thomas W Davis, and Stuart W Peltz

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Effects of remote ischemic preconditioning in high-risk patients undergoing cardiac surgery (Remote IMPACT): a randomized controlled trial., Michael Walsh, Richard Whitlock, Amit X Garg, Jean-François Légaré, Andra E Duncan, Robert Zimmerman, Scott Miller, Stephen Fremes, Teresa Kieser, Ganesan Karthikeyan, Matthew Chan, Anthony Ho, Vivian Nasr, Jessica Vincent, Imtiaz Ali, Ronit Lavi, Daniel I Sessler, Robert Kramer, Jeff Gardner, Summer Syed, Tomas VanHelder, Gordon Guyatt, Purnima Rao-Melacini, Lehana Thabane, and P J Devereaux

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Endoglin is required in Pax3-derived cells for embryonic blood vessel formation., K Young, L T Krebs, E Tweedie, B Conley, M Mancini, H M Arthur, L Liaw, T Gridley, and C P H Vary

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Free Thyroxine During Early Pregnancy and Risk for Gestational Diabetes., James E Haddow, Wendy Y Craig, Louis M Neveux, Glenn E Palomaki, Geralyn Lambert-Messerlian, Fergal D Malone, Mary E. D'Alton, and First and Second Trimester Risk of Aneuploidy (FaSTER) Research Consortium

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IGF-I and IGFBP-2 stimulate AMPK activation and autophagy, which are required for osteoblast differentiation., Gang Xi, Clifford J Rosen, and David R Clemmons

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Medication-related self-management behaviors among arthritis patients: does attentional coping style matter?, Lorie L Geryk, Susan J Blalock, Robert F DeVellis, Joanne M Jordan, Paul K J Han, and Delesha M Carpenter

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Methodological considerations when studying the skeletal response to glucose intolerance using the diet-induced obesity model., Elizabeth Rendina-Ruedy and Brenda J Smith

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Methods for Analyzing Tumor Angiogenesis in the Chick Chorioallantoic Membrane Model., Jacquelyn J Ames, Terry Henderson, Lucy Liaw, and Peter C Brooks

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miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications., Amanda J Favreau, Rose E McGlauflin, Christine W Duarte, and Pradeep Sathyanarayana

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Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat., Rea P Anunciado-Koza, Justin Manuel, and Robert A Koza

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Multiple myeloma in the marrow: pathogenesis and treatments., Heather Fairfield, Carolyne Falank, Lindsey Avery, and Michaela R Reagan

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Nephrolithiasis and risk of incident bone fracture., Eric N Taylor, Diane Feskanich, Julie M Paik, and Gary C Curhan

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Organizing graduate medical education programs into communities of practice., Robert G Bing-You and Kalli Varaklis

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Organizing graduate medical education programs into communities of practice., Robert G Bing-You and Kalli Varaklis

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Partnership, Maine Medical Center

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Prognosis driven rehabilitation after rotator cuff repair surgery., Dirk Kokmeyer, Eric Dube, and Peter J Millett

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Psychometric properties of a novel knowledge assessment tool of mechanical ventilation for emergency medicine residents in the northeastern United States., Jeremy B Richards, Tania D Strout, Todd A Seigel, and Susan R Wilcox

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Qualitative aspects of bone marrow adiposity in osteoporosis., Ana María Pino, Melissa Miranda, Carolina Figueroa, Juan Pablo Rodríguez, and Clifford J Rosen

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Reassessment of Adult Recommendations and Supplements of Calcium., John J.B. Anderson and Clifford J. Rosen

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Reply to Young, Ochi, and Marimuthu., John C Williamson, Haley G Gibbs, Christopher A Ohl, James W Johnson, James R Beardsley, Vera P Luther, and Kristina E E Rokas

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Results of the Nellix system investigational device exemption pivotal trial for endovascular aneurysm sealing., Jeffrey P Carpenter, Robert Cuff, Clifford Buckley, Christopher Healey, Sajjad Hussain, Michel M P J Reijnen, Jose Trani, and Dittmar Böckler

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Reversal of Cerebral Atrophy in a 4-Year-Old African Immigrant with Infantile-Onset Cerebral Folate Deficiency., John McLaren, Sean Conus, and Alexa Craig

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Signaling interplay between bone marrow adipose tissue and multiple myeloma cells., Carolyne Falank, Heather Fairfield, and Michaela R. Reagan

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Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients., Kevin D Ballard, Eunice Mah, Yi Guo, Richard S Bruno, Beth A Taylor, Jo Ellen Beam, Donna M Polk, and Paul D Thompson

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Skeletal integration of energy homeostasis: Translational implications., Beata Lecka-Czernik and Clifford J Rosen

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Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis., Nicole Rainville, Edward Jachimowicz, and Don M Wojchowski

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The Correlation of Skeletal and Cardiac Muscle Dysfunction in Duchenne Muscular Dystrophy., Andrew D Posner, Jonathan H Soslow, W Bryan Burnette, Aihua Bian, Ayumi Shintani, Douglas B Sawyer, and Larry W Markham

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The Impact of Travel Distance on Breast Reconstruction in the United States., Claudia R Albornoz, Wess A Cohen, Shantanu N Razdan, Babak J Mehrara, Colleen M McCarthy, Joseph J Disa, Joseph H Dayan, Andrea L Pusic, Peter G Cordeiro, and Evan Matros

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The role of clinical nurse specialists in the implementation and sustainability of a practice change., Rhonda L Babine, Cindy Honess, Heidi R Wierman, and Sarah Hallen

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The role of clinical nurse specialists in the implementation and sustainability of a practice change., Rhonda L. Babine, Cindy Honess, Heidi R. Wierman, and Sarah Hallen

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Tissue-engineered 3D cancer-in-bone modeling: silk and PUR protocols., Ushashi Dadwal, Carolyne Falank, Heather Fairfield, Sarah Linehan, Clifford J Rosen, David L Kaplan, Julie Sterling, and Michaela R Reagan

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Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones., Pietro Manuel Ferraro, Gary C Curhan, Giovanni Gambaro, and Eric N Taylor

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Treating comorbid opioid use disorder in chronic pain., Annette Matthews and Jonathan Fellers

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Twenty Years in Maine: Integrating Insights from Developmental Biology into Translational Medicine in a Small State., Thomas Gridley

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Vitamin D status of psychiatric inpatients at a community teaching hospital in the Midwest., Qiang Zeng, Timothy Dellenbaugh, Martin Maldonado, Joseph Moon, and Rob Hornstra

Submissions from 2015

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Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial., Roger Stupp, Sophie Taillibert, Andrew A Kanner, Santosh Kesari, David M Steinberg, Steven A Toms, Lynne P Taylor, Frank Lieberman, Antonio Silvani, Karen L Fink, Gene H Barnett, Jay-Jiguang Zhu, John W Henson, Herbert H Engelhard, Thomas C Chen, David D Tran, Jan Sroubek, Nam D Tran, Andreas F Hottinger, Joseph Landolfi, Rajiv Desai, Manuela Caroli, Yvonne Kew, Jerome Honnorat, Ahmed Idbaih, Eilon D Kirson, Uri Weinberg, Yoram Palti, Monika E Hegi, and Zvi Ram

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Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells., Sree Deepthi Muthukrishnan, Xuehui Yang, Robert Friesel, and Leif Oxburgh

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DLL4/Notch1 and BMP9 interdependent signaling induces human endothelial cell quiescence via P27KIP1 and thrombospondin-1., Bahman Rostama, Jacqueline E Turner, Guy T Seavey, Christine R Norton, Thomas Gridley, Calvin P H Vary, and Lucy Liaw

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Electrically Elicited Muscle Torque: Comparison Between 2500-Hz Burst-Modulated Alternating Current and Monophasic Pulsed Current., Wayne Scott, Cheryl Adams, Shantelle Cyr, Brianna Hanscom, Kevin Hill, Jeffrey Lawson, and Colin Ziegenbein

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Epidemiology of search and rescue in Baxter State Park: dangers of descent and fatigue., Chris R Welter, J Matthew Sholl, Tania D Strout, and Ben Woodard

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From the Editor: Make the Most of Every Interaction., Robert C Groom

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General consideration in the history, physical examination, and safety determination., Jonathan Buchanan, William Dexter, Amy Powell, and Justin Wright

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Hypertriglyceridemia-Induced Pancreatitis: A Decade of Experience in a Community-Based Teaching Hospital., Maxwell Eyram Afari, Hammad Shafqat, Muhammad Shafi, Fady Y Marmoush, Mary B Roberts, and Taro Minami

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"I'm peeing blood": a case of traumatic kidney laceration., Kevin M Kelleher, Anthony C Regis, and George L Higgins

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Intranasal cross-sectional area and quality of life changes following endoscopic transsphenoidal skull base surgery., Edward D McCoul, Amit S Patel, Jeffrey C Bedrosian, Vijay K Anand, and Theodore H Schwartz

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Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke., Michael Gliem, Kristina Krammes, Lucy Liaw, Nico van Rooijen, Hans-Peter Hartung, and Sebastian Jander

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Miliary tuberculosis characterised by lipomembranous fat necrosis., Lisa J Yeh, Nathan R Shively, Ross N Isacke, Christopher A Dowling, and Patricia B Stogsdill

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Physicians' perceptions of the value of prognostic models: the benefits and risks of prognostic confidence., Sarah A M Hallen, Norbert A M Hootsmans, Laura Blaisdell, Caitlin M Gutheil, and Paul K J Han

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Physicians' perceptions of the value of prognostic models: the benefits and risks of prognostic confidence., Sarah A.M. Hallen, Norbert A.M. Hootsmans, Laura Blaisdell, Caitlin M. Gutheil, and Paul K.J. Han

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Proportionate dwarfism in mice lacking heterochromatin protein 1 binding protein 3 (HP1BP3) is associated with alterations in the endocrine IGF-1 pathway., Benjamin P Garfinkel, Shiri Arad, Phuong T Le, Michael Bustin, Clifford J Rosen, Yankel Gabet, and Joseph Orly

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Psychiatric hospitalization of children with autism or intellectual disability: consensus statements on best practices., Kelly McGuire, Craig Erickson, Robin L Gabriels, Desmond Kaplan, Carla Mazefsky, John McGonigle, Jarle Meservy, Ernest Pedapati, Joseph Pierri, Logan Wink, and Matthew Siegel

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Cardiovascular risk and sodium-glucose cotransporter 2 inhibition in type 2 diabetes., Julie R Ingelfinger and Clifford J Rosen

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Cancer control of partial nephrectomy for high-risk localized renal cell carcinoma: population-based and single-institutional analysis., Rebecca L O'Malley, Matthew H Hayn, Katherine A Brewer, Willie Underwood, Nicholas J Hellenthal, Hyung L Kim, Igor Sorokin, and Thomas Schwaab

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Development and evaluation of a multidisciplinary controlled substances committee within a patient-centered medical home., Stephanie A Gernant, Rachel Bastien, and Andrea Lai

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Igfbp2 deletion in ovariectomized mice enhances energy expenditure but accelerates bone loss., Victoria E DeMambro, Phuong T Le, Anyonya R Guntur, David E Maridas, Ernesto Canalis, Kenichi Nagano, Roland Baron, David R Clemmons, and Clifford J Rosen

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Improving the nephrology match: the path forward., Chi-yuan Hsu, Mark G Parker, Michael J Ross, Rebecca J Schmidt, and Raymond C Harris

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Marrow Response to Chemotherapy and Radiation in Gynecologic Malignancies As Assessed by Water-Fat MRI., C T. Wilke, T Magome, L Arentsen, R Ghebre, L Downs, P Bolan, K E. Dusenbery, C Rosen, J Froelich, D Yee, and S K. Hui

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Questions about vitamin D for primary care practice: input from an NIH conference., Christine L Taylor, Paul R Thomas, John F Aloia, Peter S Millard, and Clifford J Rosen

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The past 10 years-new hormones, new functions, new endocrine organs., Roger Bouillon, Daniel J Drucker, Ele Ferrannini, Steven Grinspoon, Clifford J Rosen, and Paul Zimmet

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Hysteroscopic sterilization in immunocompromised patients who have intrauterine devices in place: two case reports., Camille Ladanyi, Carlie Field, and Kristina Tocce