Submissions from 2020
The Intrinsic Activity of Thyroxine is Critical for Survival and Growth and Regulates Gene expression in Neonatal Liver., Valerie Anne Galton, M Elena Martinez, Julie A Dragon, Donald L St Germain, and Arturo Hernandez
Functional study of CTHRC1 on skeletal muscle regeneration and skeletal muscle stem cells, Yong-Ri Jin, Qiaozeng Wang, Igor Prudovsky, and Volkhard Lindner
MicroRNA199b regulates mouse hematopoietic stem cells maintenance, Aldona A. Karaczyn, Edward Jachimowicz, Jaspreet S. Kohli, and Pradeep Sathyanarayana
Ten simple rules for women principal investigators during a pandemic., Pamela K Kreeger, Amy Brock, Holly C Gibbs, K Jane Grande-Allen, Alice H Huang, Kristyn S Masters, Padmini Rangamani, Michaela R. Reagan, and Shannon L Servoss
BNIP3 mediated Mitophagy is essential for osteoblast differentiation, Li Tian, Victoria Van Berlo, Vivin Karthik, Joshua P. Passarelli, and Anyonya R. Guntur
Loss of Spry1 in vascular smooth muscle cells promotes hypercholesterolemiainduced VSMC phenotypic transitions and regulates atherogenesis, Xuehui Yang, Shivangi Pande, and Robert Friesel
Submissions from 2019
Long-Term Culture of Nephron Progenitor Cells Ex Vivo., Aaron C Brown, Ashwani K Gupta, and Leif Oxburgh
Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling., Jessica Davis-Knowlton, Jacqueline E Turner, Anna Turner, Sydney Damian-Loring, Nicholas Hagler, Terry Henderson, Ivette F Emery, Kyle Bond, Christine W Duarte, Calvin P H Vary, Jens Eldrup-Jorgensen, and Lucy Liaw
Submissions from 2018
The HU177 Collagen Epitope Controls Melanoma Cell Migration and Experimental Metastasis by a CDK5/YAP-Dependent Mechanism., Jennifer M Caron, XiangHua Han, Liangru Contois, Calvin P H Vary, and Peter C Brooks
High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice., Adriana Lelis Carvalho, Victoria E DeMambro, Anyonya R Guntur, Phuong Le, Kenichi Nagano, Roland Baron, Francisco José Albuquerque de Paula, and Katherine J Motyl
Inactivation of MAP3K7 in FOXD1-expressing cells results in loss of mesangial PDGFRΒ and juvenile kidney scarring., Michele J Karolak, Justin A Guay, and Leif Oxburgh
Mesoderm-specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy., Igor Prudovsky, Rea P Anunciado-Koza, Chester G Jacobs, Doreen Kacer, Matthew E Siviski, and Robert A Koza
Loss of Spry1 attenuates vascular smooth muscle proliferation by impairing mitogen-mediated changes in cell cycle regulatory circuits., Xuehui Yang, Yan Gong, Qing He, Jonathan D Licht, Lucy Liaw, and Robert E Friesel
Submissions from 2017
Effects of treadmill exercise on advanced osteoarthritis pain in rats., Joshua Allen, Ian Imbert, Joshua Havelin, Terry Henderson, Glenn Stevenson, Lucy Liaw, and Tamara King
Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest)., Rea P Anunciado-Koza, Justin Manuel, Randall L Mynatt, Jingying Zhang, Leslie P Kozak, and Robert A Koza
Acute Treatment with the Antipsychotic Drug, Risperidone, Alters Brain Activity and Circadian Rhythms in the Heart, Megan Beauchemin, Deborah Barlow, Celeste Bouchard, Peter Caradonna, Katherine Motyl, and Karen Houseknecht
Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis., Jim Cormier, Katherine Cone, Janell Lanpher, Abigail Kinens, Terry Henderson, Lucy Liaw, Edward J Bilsky, Tamara King, Clifford J Rosen, and Glenn W Stevenson
Governing roles for Trib3 pseudokinase during stress erythropoiesis., Arvind Dev, Ruth Asch, Edward Jachimowicz, Nicole Rainville, Ashley Johnson, Emily Greenfest-Allen, and Don M Wojchowski
Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang
Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang
Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1., Yong-Ri Jin, J Patrizia Stohn, Qiaozeng Wang, Kenichi Nagano, Roland Baron, Mary L Bouxsein, Clifford J Rosen, Vyacheslav A Adarichev, and Volkhard Lindner
Human NUMB6 induces epithelial-mesenchymal transition and enhances breast cancer cells migration and Invasion., Aldona A. Karaczyn, Tamara L Adams, Robert Y S Cheng, Nicholas N Matluk, and Joseph M Verdi
Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration., Pan Li, Aldona A Karaczyn, Rose McGlauflin, Amanda J Favreau-Lessard, Edward Jachimowicz, Calvin P Vary, Kailin Xu, Don M Wojchowski, and Pradeep Sathyanarayana
ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility., Weifeng Luo, Radoslav Janoštiak, Ondřej Tolde, Larisa M Ryzhova, Lenka Koudelková, Michal Dibus, Jan Brábek, Steven K Hanks, and Daniel Rosel
A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice., Katherine J Motyl, Megan Beauchemin, Deborah Barlow, Phuong T Le, Kenichi Nagano, Annika Treyball, Anisha Contractor, Roland Baron, Clifford J Rosen, and Karen L Houseknecht
Energy metabolism of bone., Katherine J Motyl, Anyonya R Guntur, Adriana Lelis Carvalho, and Clifford J Rosen
Growth factor regulation in the nephrogenic zone of the developing kidney., Leif Oxburgh, Sree Deepthi Muthukrishnan, and Aaron Brown
New insights into fuel choices of nephron progenitor cells., Leif Oxburgh and Clifford J Rosen
Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature., Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, and Christine M Sorenson
Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity., Zhaofei Wu, M Elena Martinez, Donald L St Germain, and Arturo Hernandez
Submissions from 2016
Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer., Maria Raffaella Ambrosio, Claudia Di Serio, Giovanna Danza, Bruno Jim Rocca, Alessandro Ginori, Igor Prudovsky, Niccolò Marchionni, Maria Teresa Del Vecchio, and Francesca Tarantini
Identification of an endogenously generated cryptic collagen epitope (XL313) that may selectively regulate angiogenesis by an integrin Yes-associated protein (YAP) mechano-transduction pathway, Jacquelyn J Ames, Liangru Contois, Jennifer M Caron, Eric Tweedie, Xuehui Yang, Robert Friesel, Calvin Vary, and Peter C Brooks
Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet., Rea P Anunciado-Koza, David C Higgins, and Robert A Koza
Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat., Rea P Anunciado-Koza, Justin Manuel, and Robert A Koza
Inhibition of ovarian tumor growth by targeting the HU177 cryptic collagen epitope., Jennifer M M. Caron, Jacquelyn J. Ames, Liangru Contois, Leonard Liebes, Robert Friesel, Franco Muggia, Calvin PH Vary, Leif Oxburgh, and Peter C Brooks
miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications., Amanda J Favreau, Rose E McGlauflin, Christine W Duarte, and Pradeep Sathyanarayana
Novel biological therapies targeting heart failure: myocardial rejuvenation., Amanda J. Favreau-Lessard, Sergey Ryzhov, and Douglas B. Sawyer
Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype., Qing He, Hongyu Jing, Lucy Liaw, Lindsey Gower, Calvin Vary, Shucheng Hua, and Xuehui Yang
Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang
Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14., Maria Elena Martinez, David F. Cox, Brian P. Youth, and Arturo Hernandez
Development: Unique genetic determinants of human kidney development., Leif Oxburgh
The bioengineered kidney: science or science fiction?, Leif Oxburgh and Thomas J Carroll
Multimodal Eph/Ephrin signaling controls several phases of urogenital development., Christiane Peuckert, Bejan Aresh, Pavlo Holenya, Derek Adams, Smitha Sreedharan, Annika Porthin, Louise Andersson, Hanna Pettersson, Stefan Wölfl, Rüdiger Klein, Leif Oxburgh, and Klas Kullander
Cardiac dysfunction due to cancer therapy: finding new directions., Sergey Ryzhov, Sanjeev Francis, and Douglas B Sawyer
Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism., J Patrizia Stohn, M Elena Martinez, and Arturo Hernandez
MCT8 deficiency in male mice mitigates the phenotypic abnormalities associated with the absence of a functional type 3 deiodinase., J Patrizia Stohn, M Elena Martinez, Kassey Matoin, Beatriz Morte, Juan Bernal, Valerie Anne Galton, Donald St Germain, and Arturo Hernandez
Submissions from 2015
A synthetic niche for nephron progenitor cells., Aaron C Brown, Sree Deepthi Muthukrishnan, and Leif Oxburgh
A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development., S Castillo-Lluva, L Hontecillas-Prieto, A Blanco-Gómez, M Del Mar Sáez-Freire, B García-Cenador, J García-Criado, M Pérez-Andrés, A Orfao, M Cañamero, J H Mao, T Gridley, A Castellanos-Martín, and J Pérez-Losada
3,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects?, Arturo Hernandez
Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium., Katja Horvay, Thierry Jardé, Franca Casagranda, Victoria M Perreau, Katharina Haigh, Christian M Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J Haigh, Nick Barker, Jose M Polo, Gary R Hime, and Helen E Abud
AHNAK2 participates in the stress-induced nonclassical FGF1 secretion pathway., Aleksandr Kirov, Doreen Kacer, Barbara A Conley, Calvin P H Vary, and Igor Prudovsky
Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski
Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski
Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron., Nils O Lindström, Melanie L Lawrence, Sally F Burn, Jeanette A Johansson, Elvira R M Bakker, Rachel A Ridgway, C-Hong Chang, Michele J Karolak, Leif Oxburgh, Denis J Headon, Owen J Sansom, Ron Smits, Jamie A Davies, and Peter Hohenstein
p53 Enables metabolic fitness and self-renewal of nephron progenitor cells., Yuwen Li, Jiao Liu, Wencheng Li, Aaron Brown, Melody Baddoo, Marilyn Li, Thomas Carroll, Leif Oxburgh, Yumei Feng, and Zubaida Saifudeen
SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development., Jonathon Marks-Bluth, Anchit Khanna, Vashe Chandrakanthan, Julie Thoms, Thomas Bee, Christina Eich, Young Chan Kang, Kathy Knezevic, Qiao Qiao, Simon Fitch, Leif Oxburgh, Katrin Ottersbach, Elaine Dzierzak, Marella F T R de Bruijn, and John E Pimanda
Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells., Sree Deepthi Muthukrishnan, Xuehui Yang, Robert Friesel, and Leif Oxburgh
Parent stem cells can serve as niches for their daughter cells., Ana Pardo-Saganta, Purushothama Rao Tata, Brandon M Law, Borja Saez, Ryan Dz-Wei Chow, Mythili Prabhu, Thomas Gridley, and Jayaraj Rajagopal
DLL4/Notch1 and BMP9 interdependent signaling induces human endothelial cell quiescence via P27KIP1 and thrombospondin-1., Bahman Rostama, Jacqueline E Turner, Guy T Seavey, Christine R Norton, Thomas Gridley, Calvin P H Vary, and Lucy Liaw
Cthrc1 controls adipose tissue formation, body composition, and physical activity., J Patrizia Stohn, Qiaozeng Wang, Matthew E Siviski, Kevin Kennedy, Yong-Ri Jin, Doreen Kacer, Victoria DeMambro, Lucy Liaw, Calvin P Vary, Clifford J Rosen, Igor Prudovsky, and Volkhard Lindner
SLUG is a direct transcriptional repressor of PTEN tumor suppressor., Berna Uygur, Katrina Abramo, Evgenia Leikina, Calvin Vary, Lucy Liaw, and Wen-Shu Wu
Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors., Ana Villarejo, Patricia Molina-Ortiz, Yenny Montenegro, Gema Moreno-Bueno, Saleta Morales, Vanesa Santos, Tom Gridley, Mirna A Pérez-Moreno, Héctor Peinado, Francisco Portillo, Carmela Calés, and Amparo Cano
Fibroblast growth factor signaling in the vasculature., Xuehui Yang, Lucy Liaw, Igor Prudovsky, Peter C Brooks, Calvin Vary, Leif Oxburgh, and Robert Friesel
BMP9 crosstalk with the hippo pathway regulates endothelial cell matricellular and chemokine responses., Kira Young, Eric Tweedie, Barbara Conley, Jacquelyn Ames, MaryLynn FitzSimons, Peter Brooks, Lucy Liaw, and Calvin P H Vary
Expression of adenosine receptors in monocytes from patients with bronchial asthma., Ksenia Yuryeva, Irina Saltykova, Ludmila Ogorodova, Natalya Kirillova, Evgeny Kulikov, Elena Korotkaya, Yulia Iakovleva, Igor Feoktistov, Alexey Sazonov, and Sergey Ryzhov
Submissions from 2014
Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia., Christine W Duarte, Kimberly Murray, F Lee Lucas, Kathleen Fairfield, Heather Miller, Peter Brooks, and Calvin P H Vary
Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors., Christine W Duarte, J Patrizia Stohn, Qiaozeng Wang, Ivette F Emery, Andrew Prueser, and Volkhard Lindner
Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia., Amanda J Favreau, Calvin P H Vary, Peter C Brooks, and Pradeep Sathyanarayana
FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney., Jennifer L Fetting, Justin A Guay, Michele J Karolak, Renato V Iozzo, Derek C Adams, David E Maridas, Aaron C Brown, and Leif Oxburgh
Overview of genetic tools and techniques to study Notch signaling in mice., Thomas Gridley and Andrew K Groves
Lightening up a notch: notch regulation of energy metabolism., Thomas Gridley and Shingo Kajimura
Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis., Xiang Hua Han, Yong-Ri Jin, Leonard Tan, Tatiana Kosciuk, Jin-Seon Lee, and Jeong Kyo Yoon
Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity., Qing He, Xuehui Yang, Yan Gong, Dmitry Kovalenko, Ernesto Canalis, Clifford J Rosen, and Robert E Friesel
Effect of sustained postnatal systemic inflammation on hippocampal volume and function in mice., Shadi N Malaeb, Jonathan M Davis, Ilka M Pinz, Jennifer L Newman, Olaf Dammann, and Maribel Rios
Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions., M Elena Martinez, Marika Charalambous, Aabida Saferali, Steven Fiering, Anna K Naumova, Donald St Germain, Anne C Ferguson-Smith, and Arturo Hernandez
Bone morphogenetic protein signaling in nephron progenitor cells., Leif Oxburgh, Aaron C. Brown, Sree Deepthi Muthukrishnan, and Jennifer L. Fetting
Common features of microRNA target prediction tools., Sarah M Peterson, Jeffrey A Thompson, Melanie L Ufkin, Pradeep Sathyanarayana, Lucy Liaw, and Clare Bates Congdon
Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation., Ashleigh Poole, Nicholas Knowland, Emily Cooper, Rebecca Cole, Hongchuan Wang, Lucas Booth, Doreen Kacer, Francesca Tarantini, Robert Friesel, and Igor Prudovsky
Notch signal integration in the vasculature during remodeling., Bahman Rostama, Sarah M Peterson, Calvin P H Vary, and Lucy Liaw
miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia., Melanie L Ufkin, Sarah Peterson, Xuehui Yang, Heather Driscoll, Christine Duarte, and Pradeep Sathyanarayana
Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction., Ting Wang, Linden A Green, Samir K Gupta, Chul Kim, Liang Wang, Sharilyn Almodovar, Sonia C Flores, Igor A Prudovsky, Paul Jolicoeur, Ziyue Liu, and Matthias Clauss
Submissions from 2010
Two novel human NUMB isoforms provide a potential link between development and cancer., Aldona Karaczyn, Mahmud Bani-Yaghoub, Roger Tremblay, Chris Kubu, Rebecca Cowling, Tamara L Adams, Igor Prudovsky, Douglas Spicer, Robert Friesel, Calvin Vary, and Joseph M Verdi