The Center for Molecular Medicine at MMCRI was established with the vision of performing cutting edge biomedical research to discover the molecular mechanisms of human disease, and to harness new knowledge in developmental biology and stem cells for regenerative medicine approaches.

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Submissions from 2018

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High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice., Adriana Lelis Carvalho, Victoria E DeMambro, Anyonya R Guntur, Phuong Le, Kenichi Nagano, Roland Baron, Francisco José Albuquerque de Paula, and Katherine J Motyl

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Mesoderm-specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy., Igor Prudovsky, Rea P Anunciado-Koza, Chester G Jacobs, Doreen Kacer, Matthew E Siviski, and Robert A Koza

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Loss of Spry1 attenuates vascular smooth muscle proliferation by impairing mitogen-mediated changes in cell cycle regulatory circuits., Xuehui Yang, Yan Gong, Qing He, Jonathan D Licht, Lucy Liaw, and Robert E Friesel

Submissions from 2017

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Effects of treadmill exercise on advanced osteoarthritis pain in rats., Joshua Allen, Ian Imbert, Joshua Havelin, Terry Henderson, Glenn Stevenson, Lucy Liaw, and Tamara King

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Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest)., Rea P Anunciado-Koza, Justin Manuel, Randall L Mynatt, Jingying Zhang, Leslie P Kozak, and Robert A Koza

Acute Treatment with the Antipsychotic Drug, Risperidone, Alters Brain Activity and Circadian Rhythms in the Heart, Megan Beauchemin, Deborah Barlow, Celeste Bouchard, Peter Caradonna, Katherine Motyl, and Karen Houseknecht

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Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis., Jim Cormier, Katherine Cone, Janell Lanpher, Abigail Kinens, Terry Henderson, Lucy Liaw, Edward J Bilsky, Tamara King, Clifford J Rosen, and Glenn W Stevenson

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Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis., Jim Cormier, Katherine Cone, Janell Lanpher, Abigail Kinens, Terry Henderson, Lucy Liaw, Edward J Bilsky, Tamara King, Clifford J Rosen, and Glenn W Stevenson

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Governing roles for Trib3 pseudokinase during stress erythropoiesis., Arvind Dev, Ruth Asch, Edward Jachimowicz, Nicole Rainville, Ashley Johnson, Emily Greenfest-Allen, and Don M Wojchowski

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Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1., Yong-Ri Jin, J Patrizia Stohn, Qiaozeng Wang, Kenichi Nagano, Roland Baron, Mary L Bouxsein, Clifford J Rosen, Vyacheslav A Adarichev, and Volkhard Lindner

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Human NUMB6 induces epithelial-mesenchymal transition and enhances breast cancer cells migration and Invasion., Aldona A. Karaczyn, Tamara L Adams, Robert Y S Cheng, Nicholas N Matluk, and Joseph M Verdi

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Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration., Pan Li, Aldona A Karaczyn, Rose McGlauflin, Amanda J Favreau-Lessard, Edward Jachimowicz, Calvin P Vary, Kailin Xu, Don M Wojchowski, and Pradeep Sathyanarayana

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ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility., Weifeng Luo, Radoslav Janoštiak, Ondřej Tolde, Larisa M Ryzhova, Lenka Koudelková, Michal Dibus, Jan Brábek, Steven K Hanks, and Daniel Rosel

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A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice., Katherine J Motyl, Megan Beauchemin, Deborah Barlow, Phuong T Le, Kenichi Nagano, Annika Treyball, Anisha Contractor, Roland Baron, Clifford J Rosen, and Karen L Houseknecht

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Energy metabolism of bone., Katherine J Motyl, Anyonya R Guntur, Adriana Lelis Carvalho, and Clifford J Rosen

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Growth factor regulation in the nephrogenic zone of the developing kidney., Leif Oxburgh, Sree Deepthi Muthukrishnan, and Aaron Brown

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New insights into fuel choices of nephron progenitor cells., Leif Oxburgh and Clifford J Rosen

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Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature., Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, and Christine M Sorenson

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Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature., Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, and Christine M Sorenson

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Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity., Zhaofei Wu, M Elena Martinez, Donald L St Germain, and Arturo Hernandez

Submissions from 2016

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Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer., Maria Raffaella Ambrosio, Claudia Di Serio, Giovanna Danza, Bruno Jim Rocca, Alessandro Ginori, Igor Prudovsky, Niccolò Marchionni, Maria Teresa Del Vecchio, and Francesca Tarantini

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Identification of an endogenously generated cryptic collagen epitope (XL313) that may selectively regulate angiogenesis by an integrin Yes-associated protein (YAP) mechano-transduction pathway, Jacquelyn J Ames, Liangru Contois, Jennifer M Caron, Eric Tweedie, Xuehui Yang, Robert Friesel, Calvin Vary, and Peter C Brooks

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Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat., Rea P Anunciado-Koza, Justin Manuel, and Robert A Koza

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Inhibition of ovarian tumor growth by targeting the HU177 cryptic collagen epitope., Jennifer M M. Caron, Jacquelyn J. Ames, Liangru Contois, Leonard Liebes, Robert Friesel, Franco Muggia, Calvin PH Vary, Leif Oxburgh, and Peter C Brooks

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miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications., Amanda J Favreau, Rose E McGlauflin, Christine W Duarte, and Pradeep Sathyanarayana

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Novel biological therapies targeting heart failure: myocardial rejuvenation., Amanda J. Favreau-Lessard, Sergey Ryzhov, and Douglas B. Sawyer

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Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14., Maria Elena Martinez, David F. Cox, Brian P. Youth, and Arturo Hernandez

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Multimodal Eph/Ephrin signaling controls several phases of urogenital development., Christiane Peuckert, Bejan Aresh, Pavlo Holenya, Derek Adams, Smitha Sreedharan, Annika Porthin, Louise Andersson, Hanna Pettersson, Stefan Wölfl, Rüdiger Klein, Leif Oxburgh, and Klas Kullander

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Cardiac dysfunction due to cancer therapy: finding new directions., Sergey Ryzhov, Sanjeev Francis, and Douglas B Sawyer

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Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism., J Patrizia Stohn, M Elena Martinez, and Arturo Hernandez

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MCT8 deficiency in male mice mitigates the phenotypic abnormalities associated with the absence of a functional type 3 deiodinase., J Patrizia Stohn, M Elena Martinez, Kassey Matoin, Beatriz Morte, Juan Bernal, Valerie Anne Galton, Donald St Germain, and Arturo Hernandez

Submissions from 2015

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3,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects?, Arturo Hernandez

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Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium., Katja Horvay, Thierry Jardé, Franca Casagranda, Victoria M Perreau, Katharina Haigh, Christian M Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J Haigh, Nick Barker, Jose M Polo, Gary R Hime, and Helen E Abud

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AHNAK2 participates in the stress-induced nonclassical FGF1 secretion pathway., Aleksandr Kirov, Doreen Kacer, Barbara A Conley, Calvin P H Vary, and Igor Prudovsky

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Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski

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Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron., Nils O Lindström, Melanie L Lawrence, Sally F Burn, Jeanette A Johansson, Elvira R M Bakker, Rachel A Ridgway, C-Hong Chang, Michele J Karolak, Leif Oxburgh, Denis J Headon, Owen J Sansom, Ron Smits, Jamie A Davies, and Peter Hohenstein

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p53 Enables metabolic fitness and self-renewal of nephron progenitor cells., Yuwen Li, Jiao Liu, Wencheng Li, Aaron Brown, Melody Baddoo, Marilyn Li, Thomas Carroll, Leif Oxburgh, Yumei Feng, and Zubaida Saifudeen

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SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development., Jonathon Marks-Bluth, Anchit Khanna, Vashe Chandrakanthan, Julie Thoms, Thomas Bee, Christina Eich, Young Chan Kang, Kathy Knezevic, Qiao Qiao, Simon Fitch, Leif Oxburgh, Katrin Ottersbach, Elaine Dzierzak, Marella F T R de Bruijn, and John E Pimanda

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Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells., Sree Deepthi Muthukrishnan, Xuehui Yang, Robert Friesel, and Leif Oxburgh

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Parent stem cells can serve as niches for their daughter cells., Ana Pardo-Saganta, Purushothama Rao Tata, Brandon M Law, Borja Saez, Ryan Dz-Wei Chow, Mythili Prabhu, Thomas Gridley, and Jayaraj Rajagopal

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DLL4/Notch1 and BMP9 interdependent signaling induces human endothelial cell quiescence via P27KIP1 and thrombospondin-1., Bahman Rostama, Jacqueline E Turner, Guy T Seavey, Christine R Norton, Thomas Gridley, Calvin P H Vary, and Lucy Liaw

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Cthrc1 controls adipose tissue formation, body composition, and physical activity., J Patrizia Stohn, Qiaozeng Wang, Matthew E Siviski, Kevin Kennedy, Yong-Ri Jin, Doreen Kacer, Victoria DeMambro, Lucy Liaw, Calvin P Vary, Clifford J Rosen, Igor Prudovsky, and Volkhard Lindner

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SLUG is a direct transcriptional repressor of PTEN tumor suppressor., Berna Uygur, Katrina Abramo, Evgenia Leikina, Calvin Vary, Lucy Liaw, and Wen-Shu Wu

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Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors., Ana Villarejo, Patricia Molina-Ortiz, Yenny Montenegro, Gema Moreno-Bueno, Saleta Morales, Vanesa Santos, Tom Gridley, Mirna A Pérez-Moreno, Héctor Peinado, Francisco Portillo, Carmela Calés, and Amparo Cano

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Fibroblast growth factor signaling in the vasculature., Xuehui Yang, Lucy Liaw, Igor Prudovsky, Peter C Brooks, Calvin Vary, Leif Oxburgh, and Robert Friesel

Submissions from 2014

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Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia., Christine W Duarte, Kimberly Murray, F Lee Lucas, Kathleen Fairfield, Heather Miller, Peter Brooks, and Calvin P H Vary

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Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors., Christine W Duarte, J Patrizia Stohn, Qiaozeng Wang, Ivette F Emery, Andrew Prueser, and Volkhard Lindner

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Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia., Amanda J Favreau, Calvin P H Vary, Peter C Brooks, and Pradeep Sathyanarayana

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FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney., Jennifer L Fetting, Justin A Guay, Michele J Karolak, Renato V Iozzo, Derek C Adams, David E Maridas, Aaron C Brown, and Leif Oxburgh

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Overview of genetic tools and techniques to study Notch signaling in mice., Thomas Gridley and Andrew K Groves

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Lightening up a notch: notch regulation of energy metabolism., Thomas Gridley and Shingo Kajimura

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Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis., Xiang Hua Han, Yong-Ri Jin, Leonard Tan, Tatiana Kosciuk, Jin-Seon Lee, and Jeong Kyo Yoon

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Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity., Qing He, Xuehui Yang, Yan Gong, Dmitry Kovalenko, Ernesto Canalis, Clifford J Rosen, and Robert E Friesel

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Effect of sustained postnatal systemic inflammation on hippocampal volume and function in mice., Shadi N Malaeb, Jonathan M Davis, Ilka M Pinz, Jennifer L Newman, Olaf Dammann, and Maribel Rios

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Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions., M Elena Martinez, Marika Charalambous, Aabida Saferali, Steven Fiering, Anna K Naumova, Donald St Germain, Anne C Ferguson-Smith, and Arturo Hernandez

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Bone morphogenetic protein signaling in nephron progenitor cells., Leif Oxburgh, Aaron C. Brown, Sree Deepthi Muthukrishnan, and Jennifer L. Fetting

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Common features of microRNA target prediction tools., Sarah M Peterson, Jeffrey A Thompson, Melanie L Ufkin, Pradeep Sathyanarayana, Lucy Liaw, and Clare Bates Congdon

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Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation., Ashleigh Poole, Nicholas Knowland, Emily Cooper, Rebecca Cole, Hongchuan Wang, Lucas Booth, Doreen Kacer, Francesca Tarantini, Robert Friesel, and Igor Prudovsky

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Notch signal integration in the vasculature during remodeling., Bahman Rostama, Sarah M Peterson, Calvin P H Vary, and Lucy Liaw

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miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia., Melanie L Ufkin, Sarah Peterson, Xuehui Yang, Heather Driscoll, Christine Duarte, and Pradeep Sathyanarayana

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Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction., Ting Wang, Linden A Green, Samir K Gupta, Chul Kim, Liang Wang, Sharilyn Almodovar, Sonia C Flores, Igor A Prudovsky, Paul Jolicoeur, Ziyue Liu, and Matthias Clauss