The Center for Molecular Medicine at MMCRI was established with the vision of performing cutting edge biomedical research to discover the molecular mechanisms of human disease, and to harness new knowledge in developmental biology and stem cells for regenerative medicine approaches.

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Submissions from 2017

Acute Treatment with the Antipsychotic Drug, Risperidone, Alters Brain Activity and Circadian Rhythms in the Heart, Megan Beauchemin, Deborah Barlow, Celeste Bouchard, Peter Caradonna, Katherine Motyl, and Karen Houseknecht

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Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis., Jim Cormier, Katherine Cone, Janell Lanpher, Abigail Kinens, Terry Henderson, Lucy Liaw, Edward J Bilsky, Tamara King, Clifford J Rosen, and Glenn W Stevenson

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Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Human NUMB6 induces epithelial-mesenchymal transition and enhances breast cancer cells migration and Invasion., Aldona A. Karaczyn, Tamara L Adams, Robert Y S Cheng, Nicholas N Matluk, and Joseph M Verdi

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ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility., Weifeng Luo, Radoslav Janoštiak, Ondřej Tolde, Larisa M Ryzhova, Lenka Koudelková, Michal Dibus, Jan Brábek, Steven K Hanks, and Daniel Rosel

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Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature., Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, and Christine M Sorenson

Submissions from 2016

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Identification of an endogenously generated cryptic collagen epitope (XL313) that may selectively regulate angiogenesis by an integrin Yes-associated protein (YAP) mechano-transduction pathway, Jacquelyn J Ames, Liangru Contois, Jennifer M Caron, Eric Tweedie, Xuehui Yang, Robert Friesel, Calvin Vary, and Peter C Brooks

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Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat., Rea P Anunciado-Koza, Justin Manuel, and Robert A Koza

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miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications., Amanda J Favreau, Rose E McGlauflin, Christine W Duarte, and Pradeep Sathyanarayana

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Novel biological therapies targeting heart failure: myocardial rejuvenation., Amanda J. Favreau-Lessard, Sergey Ryzhov, and Douglas B. Sawyer

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Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14., Maria Elena Martinez, David F. Cox, Brian P. Youth, and Arturo Hernandez

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Multimodal Eph/Ephrin signaling controls several phases of urogenital development., Christiane Peuckert, Bejan Aresh, Pavlo Holenya, Derek Adams, Smitha Sreedharan, Annika Porthin, Louise Andersson, Hanna Pettersson, Stefan Wölfl, Rüdiger Klein, Leif Oxburgh, and Klas Kullander

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Cardiac dysfunction due to cancer therapy: finding new directions., Sergey Ryzhov, Sanjeev Francis, and Douglas B Sawyer

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Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism., J Patrizia Stohn, M Elena Martinez, and Arturo Hernandez

Submissions from 2015

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Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells., Sree Deepthi Muthukrishnan, Xuehui Yang, Robert Friesel, and Leif Oxburgh

Submissions from 2014

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Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia., Christine W Duarte, Kimberly Murray, F Lee Lucas, Kathleen Fairfield, Heather Miller, Peter Brooks, and Calvin P H Vary

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Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors., Christine W Duarte, J Patrizia Stohn, Qiaozeng Wang, Ivette F Emery, Andrew Prueser, and Volkhard Lindner

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Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia., Amanda J Favreau, Calvin P H Vary, Peter C Brooks, and Pradeep Sathyanarayana

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FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney., Jennifer L Fetting, Justin A Guay, Michele J Karolak, Renato V Iozzo, Derek C Adams, David E Maridas, Aaron C Brown, and Leif Oxburgh

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Overview of genetic tools and techniques to study Notch signaling in mice., Thomas Gridley and Andrew K Groves

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Lightening up a notch: notch regulation of energy metabolism., Thomas Gridley and Shingo Kajimura

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Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis., Xiang Hua Han, Yong-Ri Jin, Leonard Tan, Tatiana Kosciuk, Jin-Seon Lee, and Jeong Kyo Yoon

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Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity., Qing He, Xuehui Yang, Yan Gong, Dmitry Kovalenko, Ernesto Canalis, Clifford J Rosen, and Robert E Friesel

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Effect of sustained postnatal systemic inflammation on hippocampal volume and function in mice., Shadi N Malaeb, Jonathan M Davis, Ilka M Pinz, Jennifer L Newman, Olaf Dammann, and Maribel Rios

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Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions., M Elena Martinez, Marika Charalambous, Aabida Saferali, Steven Fiering, Anna K Naumova, Donald St Germain, Anne C Ferguson-Smith, and Arturo Hernandez

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Bone morphogenetic protein signaling in nephron progenitor cells., Leif Oxburgh, Aaron C. Brown, Sree Deepthi Muthukrishnan, and Jennifer L. Fetting

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Common features of microRNA target prediction tools., Sarah M Peterson, Jeffrey A Thompson, Melanie L Ufkin, Pradeep Sathyanarayana, Lucy Liaw, and Clare Bates Congdon

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Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation., Ashleigh Poole, Nicholas Knowland, Emily Cooper, Rebecca Cole, Hongchuan Wang, Lucas Booth, Doreen Kacer, Francesca Tarantini, Robert Friesel, and Igor Prudovsky

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Notch signal integration in the vasculature during remodeling., Bahman Rostama, Sarah M Peterson, Calvin P H Vary, and Lucy Liaw

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miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia., Melanie L Ufkin, Sarah Peterson, Xuehui Yang, Heather Driscoll, Christine Duarte, and Pradeep Sathyanarayana

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Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction., Ting Wang, Linden A Green, Samir K Gupta, Chul Kim, Liang Wang, Sharilyn Almodovar, Sonia C Flores, Igor A Prudovsky, Paul Jolicoeur, Ziyue Liu, and Matthias Clauss