Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. MaineHealth Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2016

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Reply to Young, Ochi, and Marimuthu., John C Williamson, Haley G Gibbs, Christopher A Ohl, James W Johnson, James R Beardsley, Vera P Luther, and Kristina E E Rokas

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Results of the Nellix system investigational device exemption pivotal trial for endovascular aneurysm sealing., Jeffrey P Carpenter, Robert Cuff, Clifford Buckley, Christopher Healey, Sajjad Hussain, Michel M P J Reijnen, Jose Trani, and Dittmar Böckler

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Reversal of Cerebral Atrophy in a 4-Year-Old African Immigrant with Infantile-Onset Cerebral Folate Deficiency., John McLaren, Sean Conus, and Alexa Craig

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Signaling interplay between bone marrow adipose tissue and multiple myeloma cells., Carolyne Falank, Heather Fairfield, and Michaela R. Reagan

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Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients., Kevin D Ballard, Eunice Mah, Yi Guo, Richard S Bruno, Beth A Taylor, Jo Ellen Beam, Donna M Polk, and Paul D Thompson

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Skeletal integration of energy homeostasis: Translational implications., Beata Lecka-Czernik and Clifford J Rosen

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Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis., Nicole Rainville, Edward Jachimowicz, and Don M Wojchowski

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The Correlation of Skeletal and Cardiac Muscle Dysfunction in Duchenne Muscular Dystrophy., Andrew D Posner, Jonathan H Soslow, W Bryan Burnette, Aihua Bian, Ayumi Shintani, Douglas B Sawyer, and Larry W Markham

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The Impact of Travel Distance on Breast Reconstruction in the United States., Claudia R Albornoz, Wess A Cohen, Shantanu N Razdan, Babak J Mehrara, Colleen M McCarthy, Joseph J Disa, Joseph H Dayan, Andrea L Pusic, Peter G Cordeiro, and Evan Matros

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The role of clinical nurse specialists in the implementation and sustainability of a practice change., Rhonda L Babine, Cindy Honess, Heidi R Wierman, and Sarah Hallen

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The role of clinical nurse specialists in the implementation and sustainability of a practice change., Rhonda L. Babine, Cindy Honess, Heidi R. Wierman, and Sarah Hallen

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Tissue-engineered 3D cancer-in-bone modeling: silk and PUR protocols., Ushashi Dadwal, Carolyne Falank, Heather Fairfield, Sarah Linehan, Clifford J Rosen, David L Kaplan, Julie Sterling, and Michaela R Reagan

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Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones., Pietro Manuel Ferraro, Gary C Curhan, Giovanni Gambaro, and Eric N Taylor

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Treating comorbid opioid use disorder in chronic pain., Annette Matthews and Jonathan Fellers

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Twenty Years in Maine: Integrating Insights from Developmental Biology into Translational Medicine in a Small State., Thomas Gridley

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Vitamin D status of psychiatric inpatients at a community teaching hospital in the Midwest., Qiang Zeng, Timothy Dellenbaugh, Martin Maldonado, Joseph Moon, and Rob Hornstra

Submissions from 2015

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Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial., Roger Stupp, Sophie Taillibert, Andrew A Kanner, Santosh Kesari, David M Steinberg, Steven A Toms, Lynne P Taylor, Frank Lieberman, Antonio Silvani, Karen L Fink, Gene H Barnett, Jay-Jiguang Zhu, John W Henson, Herbert H Engelhard, Thomas C Chen, David D Tran, Jan Sroubek, Nam D Tran, Andreas F Hottinger, Joseph Landolfi, Rajiv Desai, Manuela Caroli, Yvonne Kew, Jerome Honnorat, Ahmed Idbaih, Eilon D Kirson, Uri Weinberg, Yoram Palti, Monika E Hegi, and Zvi Ram

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Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells., Sree Deepthi Muthukrishnan, Xuehui Yang, Robert Friesel, and Leif Oxburgh

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DLL4/Notch1 and BMP9 interdependent signaling induces human endothelial cell quiescence via P27KIP1 and thrombospondin-1., Bahman Rostama, Jacqueline E Turner, Guy T Seavey, Christine R Norton, Thomas Gridley, Calvin P H Vary, and Lucy Liaw

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Electrically Elicited Muscle Torque: Comparison Between 2500-Hz Burst-Modulated Alternating Current and Monophasic Pulsed Current., Wayne Scott, Cheryl Adams, Shantelle Cyr, Brianna Hanscom, Kevin Hill, Jeffrey Lawson, and Colin Ziegenbein

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Epidemiology of search and rescue in Baxter State Park: dangers of descent and fatigue., Chris R Welter, J Matthew Sholl, Tania D Strout, and Ben Woodard

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From the Editor: Make the Most of Every Interaction., Robert C Groom

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General consideration in the history, physical examination, and safety determination., Jonathan Buchanan, William Dexter, Amy Powell, and Justin Wright

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Hypertriglyceridemia-Induced Pancreatitis: A Decade of Experience in a Community-Based Teaching Hospital., Maxwell Eyram Afari, Hammad Shafqat, Muhammad Shafi, Fady Y Marmoush, Mary B Roberts, and Taro Minami

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"I'm peeing blood": a case of traumatic kidney laceration., Kevin M Kelleher, Anthony C Regis, and George L Higgins

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Intranasal cross-sectional area and quality of life changes following endoscopic transsphenoidal skull base surgery., Edward D McCoul, Amit S Patel, Jeffrey C Bedrosian, Vijay K Anand, and Theodore H Schwartz

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Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke., Michael Gliem, Kristina Krammes, Lucy Liaw, Nico van Rooijen, Hans-Peter Hartung, and Sebastian Jander

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Miliary tuberculosis characterised by lipomembranous fat necrosis., Lisa J Yeh, Nathan R Shively, Ross N Isacke, Christopher A Dowling, and Patricia B Stogsdill

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Physicians' perceptions of the value of prognostic models: the benefits and risks of prognostic confidence., Sarah A M Hallen, Norbert A M Hootsmans, Laura Blaisdell, Caitlin M Gutheil, and Paul K J Han

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Physicians' perceptions of the value of prognostic models: the benefits and risks of prognostic confidence., Sarah A.M. Hallen, Norbert A.M. Hootsmans, Laura Blaisdell, Caitlin M. Gutheil, and Paul K.J. Han

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Proportionate dwarfism in mice lacking heterochromatin protein 1 binding protein 3 (HP1BP3) is associated with alterations in the endocrine IGF-1 pathway., Benjamin P Garfinkel, Shiri Arad, Phuong T Le, Michael Bustin, Clifford J Rosen, Yankel Gabet, and Joseph Orly

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Psychiatric hospitalization of children with autism or intellectual disability: consensus statements on best practices., Kelly McGuire, Craig Erickson, Robin L Gabriels, Desmond Kaplan, Carla Mazefsky, John McGonigle, Jarle Meservy, Ernest Pedapati, Joseph Pierri, Logan Wink, and Matthew Siegel

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Cardiovascular risk and sodium-glucose cotransporter 2 inhibition in type 2 diabetes., Julie R Ingelfinger and Clifford J Rosen

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Cancer control of partial nephrectomy for high-risk localized renal cell carcinoma: population-based and single-institutional analysis., Rebecca L O'Malley, Matthew H Hayn, Katherine A Brewer, Willie Underwood, Nicholas J Hellenthal, Hyung L Kim, Igor Sorokin, and Thomas Schwaab

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Development and evaluation of a multidisciplinary controlled substances committee within a patient-centered medical home., Stephanie A Gernant, Rachel Bastien, and Andrea Lai

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Igfbp2 deletion in ovariectomized mice enhances energy expenditure but accelerates bone loss., Victoria E DeMambro, Phuong T Le, Anyonya R Guntur, David E Maridas, Ernesto Canalis, Kenichi Nagano, Roland Baron, David R Clemmons, and Clifford J Rosen

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Improving the nephrology match: the path forward., Chi-yuan Hsu, Mark G Parker, Michael J Ross, Rebecca J Schmidt, and Raymond C Harris

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Marrow Response to Chemotherapy and Radiation in Gynecologic Malignancies As Assessed by Water-Fat MRI., C T. Wilke, T Magome, L Arentsen, R Ghebre, L Downs, P Bolan, K E. Dusenbery, C Rosen, J Froelich, D Yee, and S K. Hui

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Questions about vitamin D for primary care practice: input from an NIH conference., Christine L Taylor, Paul R Thomas, John F Aloia, Peter S Millard, and Clifford J Rosen

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The past 10 years-new hormones, new functions, new endocrine organs., Roger Bouillon, Daniel J Drucker, Ele Ferrannini, Steven Grinspoon, Clifford J Rosen, and Paul Zimmet

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Hysteroscopic sterilization in immunocompromised patients who have intrauterine devices in place: two case reports., Camille Ladanyi, Carlie Field, and Kristina Tocce

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Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis., David T Paik, Meena Rai, Sergey Ryzhov, Lehanna N Sanders, Omonigho Aisagbonhi, Mitchell J Funke, Igor Feoktistov, and Antonis K Hatzopoulos

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Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia., Seth E Karol, Wenjian Yang, Sara L Van Driest, Tamara Y Chang, Sue Kaste, Erica Bowton, Melissa Basford, Lisa Bastarache, Dan M Roden, Joshua C Denny, Eric Larsen, Naomi Winick, William L Carroll, Cheng Cheng, Deqing Pei, Christian A Fernandez, Chengcheng Liu, Colton Smith, Mignon L Loh, Elizabeth A Raetz, Stephen P Hunger, Paul Scheet, Sima Jeha, Ching-Hon Pui, William E Evans, Meenakshi Devidas, Leonard A Mattano, and Mary V Relling

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Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia., Seth E Karol, Wenjian Yang, Sara L Van Driest, Tamara Y Chang, Sue Kaste, Erica Bowton, Melissa Basford, Lisa Bastarache, Dan M Roden, Joshua C Denny, Eric Larsen, Naomi Winick, William L Carroll, Cheng Cheng, Deqing Pei, Christian A Fernandez, Chengcheng Liu, Colton Smith, Mignon L Loh, Elizabeth A Raetz, Stephen P Hunger, Paul Scheet, Sima Jeha, Ching-Hon Pui, William E Evans, Meenakshi Devidas, Leonard A Mattano, and Mary V Relling

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Agitation in the Emergency Department: Importance of Schizophrenia and Related Disorders., T D. Strout and M R. Baumann

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Beyond Cavities and Emphysema., Akshu Balwan, Thomas Van der Kloot, and Jennifer Palminteri

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Closing the Treatment Gap for Cardiac Rehabilitation., Donna M Polk and Patrick T O'Gara

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Culture Conditions for Expansion of Nephron Progenitor Cells, Aaron C. Brown and Leif Oxburgh

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Does a Visual Cue Checklist Improve Communication and Adherence to Best Practices in the Emergency Critical Care Setting?, T D. Strout, S A. Haydar, and V Smith

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Effectiveness of regionalized systems for stroke and myocardial infarction., James P Rhudy, Marie A Bakitas, Kristiina Hyrkäs, Rita A Jablonski-Jaudon, Erica R Pryor, Henry E Wang, and Anne W Alexandrov

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Effects of personalized colorectal cancer risk information on laypersons' interest in colorectal cancer screening: The importance of individual differences., Paul K J Han, Christine W Duarte, Susannah Daggett, Andrea Siewers, Bill Killam, Kahsi A Smith, and Andrew N Freedman

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Enhancing Adolescent and Young Adult Oncology Research Within the National Clinical Trials Network: Rationale, Progress, and Emerging Strategies., Aaron R Weiss, Craig R Nichols, and David R Freyer

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Etomidate in sepsis: understanding the dilemma., David J Gagnon and David B Seder

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Genetic information-seeking behaviors and knowledge among family members and patients with inherited bone marrow failure syndromes., Jada G Hamilton, Sadie P Hutson, Amy E Frohnmayer, Paul K J Han, June A Peters, Ann G Carr, and Blanche P Alter

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Perceived ambiguity as a barrier to intentions to learn genome sequencing results., Jennifer M Taber, William M P Klein, Rebecca A Ferrer, Paul K J Han, Katie L Lewis, Leslie G Biesecker, and Barbara B Biesecker

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Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice., David A Hartmann, Robert G Underly, Roger I Grant, Ashley N Watson, Volkhard Lindner, and Andy Y Shih

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Pilot Evaluation of a Pulmonary Specialty-Based Lung Cancer Screening Program., Akshu Balwan, Paul Han, Caitlin Gutheil, Adam Black, Barbara Grillo, Sharon Siegel, Jason Yahwak, and Mayuko Fukunaga

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Recurrent human papillomavirus-related airway squamous cell carcinomas., Akshu Balwan, Hagen Blaszyk, and Thomas E Van der Kloot

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The use of haematopoietic stem cell transplantation in Fanconi anaemia patients: a survey of decision making among families in the US and Canada., Sadie P Hutson, Paul K J Han, Jada G Hamilton, Sean C Rife, Mohamad M Al-Rahawan, Richard P Moser, Seth P Duty, Sheeba Anand, and Blanche P Alter

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Treatment of arthritis associated with Legg-Calve-Perthes disease with modular total hip arthroplasty., Christopher R Seufert and Brian J McGrory

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Utility of the Modified “Surprise Question” for Predicting Inpatient Mortality in Emergency Department Patients., T D. Strout, S A. Haydar, P J.K. Han, and A G. Bond

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Expression of adenosine receptors in monocytes from patients with bronchial asthma., Ksenia Yuryeva, Irina Saltykova, Ludmila Ogorodova, Natalya Kirillova, Evgeny Kulikov, Elena Korotkaya, Yulia Iakovleva, Igor Feoktistov, Alexey Sazonov, and Sergey Ryzhov

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A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development., S Castillo-Lluva, L Hontecillas-Prieto, A Blanco-Gómez, M Del Mar Sáez-Freire, B García-Cenador, J García-Criado, M Pérez-Andrés, A Orfao, M Cañamero, J H Mao, T Gridley, A Castellanos-Martín, and J Pérez-Losada

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Adipose tissue residing progenitors (adipocyte lineage progenitors and adipose derived stem cells (ADSC)., Ryan Berry, Matthew S Rodeheffer, Clifford J Rosen, and Mark C Horowitz

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A high fat diet increases bone marrow adipose tissue (MAT) but does not alter trabecular or cortical bone mass in C57BL/6J mice., Casey R Doucette, Mark C Horowitz, Ryan Berry, Ormond A MacDougald, Rea Anunciado-Koza, Robert A Koza, and Clifford J Rosen

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Airway Management in Patients With Abnormal Anatomy or Challenging Physiology., Nathan W. Mick

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A phase II evaluation of cediranib in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group study., David Bender, Michael W Sill, Heather A Lankes, Henry D Reyes, Christopher J Darus, James E Delmore, Jacob Rotmensch, Heidi J Gray, Robert S Mannel, Jeanne M Schilder, Mark I Hunter, Carolyn K McCourt, Megan I Samuelson, and Kimberly K Leslie

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A phase II trial of trebananib (AMG 386; IND#111071), a selective angiopoietin 1/2 neutralizing peptibody, in patients with persistent/recurrent carcinoma of the endometrium: an NRG/Gynecologic Oncology Group trial., Kathleen N Moore, Michael W Sill, Meaghan E Tenney, Christopher J Darus, David Griffin, Theresa L Werner, Peter G Rose, and Robert Behrens

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Assessment of food intake, obesity, and health risk among the homeless in Rhode Island., Diane C Martins, Kathleen S Gorman, Robin J Miller, Leah Murphy, Sekboppa Sor, Jonah C Martins, and Maria L Vecchiarelli

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Carotid flow time changes with volume status in acute blood loss., David C Mackenzie, Noman A Khan, David Blehar, Scott Glazier, Yuchiao Chang, Christopher P Stowell, Vicki E Noble, and Andrew S Liteplo

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Cervical cancer screening and follow-up in 4 geographically diverse US health care systems, 1998 through 2007., Sheila Weinmann, Andrew E Williams, Aruna Kamineni, Diana S M Buist, Erin E Masterson, Natasha K Stout, Azadeh Stark, Tyler R Ross, Christopher L Owens, Terry S Field, and Chyke A Doubeni

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Evaluating adverse rural crash outcomes using the NHTSA State Data System., Christine Peura, Joseph A Kilch, and David E Clark

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From the Editor: The Journey to Open Access., Robert C Groom

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General Consideration in the History, Physical Examination, and Safety Determination., Jonathan Buchanan, William Dexter, Amy Powell, and Justin Wright

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Heart rate variables in the Vascular Quality Initiative are not reliable predictors of adverse cardiac outcomes or mortality after major elective vascular surgery., Salvatore Scali, Daniel Bertges, Daniel Neal, Virendra Patel, Jens Eldrup-Jorgensen, Jack Cronenwett, and Adam Beck

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High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes., Joshua C Anderson, Christopher D Willey, Amitkumar Mehta, Karim Welaya, Dongquan Chen, Christine W Duarte, Pooja Ghatalia, Waleed Arafat, Ankit Madan, Sunil Sudarshan, Gurudatta Naik, William E Grizzle, Toni K Choueiri, and Guru Sonpavde

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Large penile mass with unusual benign histopathology., Nate Johnson, Maria Voznesensky, and Graham VerLee

Paravertebral analgesia in transapical transcatheter aortic valve replacement., Justin M. Poltak, Frederick C. Cobey, John G. Augoustides, and Christopher W. Connors

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Pediatric professional medical associations and industry guideline compliance., Matthew Siegel, Amy Stedman, and Kahsi A Smith

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Predonation direct and indirect costs incurred by adults who donated a kidney: findings from the KDOC study., J R Rodrigue, J D Schold, P Morrissey, J Whiting, J Vella, L K Kayler, D Katz, J Jones, B Kaplan, A Fleishman, M Pavlakis, and D A Mandelbrot

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Preservation of multidimensional quality of life after endoscopic pituitary adenoma resection., Edward D McCoul, Jeffrey C Bedrosian, Olga Akselrod, Vijay K Anand, and Theodore H Schwartz

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Survival following Ommaya reservoir placement for neoplastic meningitis., Marie Roguski, Anand Rughani, Chih-Ta Lin, Deborah A Cushing, Jeffrey E Florman, and Julian K Wu

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Temporal changes in tolerance of uncertainty among medical students: insights from an exploratory study., Paul K J Han, Daniel Schupack, Susannah Daggett, Christina T Holt, and Tania D Strout

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The authors reply., David B Seder, Richard R Riker, and Niklas Nielsen

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Unraveling the function of FTO variants., Clifford J Rosen and Julie R Ingelfinger

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Urinary phenylacetylglutamine (U-PAGN) concentration as biomarker for adherence in patients with urea cycle disorders (UCD) treated with glycerol phenylbutyrate., M Mokhtarani, G A Diaz, U Lichter-Konecki, S A Berry, J Bartley, S E McCandless, W Smith, C Harding, C Le Mons, D F Coakley, B Lee, and B F Scharschmidt

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Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues., Erica L Scheller, Casey R Doucette, Brian S Learman, William P Cawthorn, Shaima Khandaker, Benjamin Schell, Brent Wu, Shi-Ying Ding, Miriam A Bredella, Pouneh K Fazeli, Basma Khoury, Karl J Jepsen, Paul F Pilch, Anne Klibanski, Clifford J Rosen, and Ormond A MacDougald

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AHNAK2 participates in the stress-induced nonclassical FGF1 secretion pathway., Aleksandr Kirov, Doreen Kacer, Barbara A Conley, Calvin P H Vary, and Igor Prudovsky

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Clean intermittent catheterization as an initial management strategy provides for adequate preservation of renal function in newborns with persistent cloaca., David J Chalmers, Kyle O Rove, Cole A Wiedel, Suhong Tong, Georgette L Siparsky, and Duncan T Wilcox

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Cthrc1 controls adipose tissue formation, body composition, and physical activity., J Patrizia Stohn, Qiaozeng Wang, Matthew E Siviski, Kevin Kennedy, Yong-Ri Jin, Doreen Kacer, Victoria DeMambro, Lucy Liaw, Calvin P Vary, Clifford J Rosen, Igor Prudovsky, and Volkhard Lindner

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Delivering a decision support intervention about PSA screening to patients outside of clinical encounters is ineffective in promoting informed decision-making., Paul K J Han

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Energy excess, glucose utilization, and skeletal remodeling: new insights., Beata Lecka-Czernik and Clifford J Rosen

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Myocardial infarction in the setting of anaphylaxis to celecoxib: a case of Kounis syndrome., Anthony C Regis, Carl A Germann, and Jacob G Crowell

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Point-of-care ultrasound education for non-physician clinicians in a resource-limited emergency department., Lori A Stolz, Krithika M Muruganandan, Mark C Bisanzo, Mugisha J Sebikali, Bradley A Dreifuss, Heather S Hammerstedt, Sara W Nelson, Irene Nayabale, Srikar Adhikari, and Sachita P Shah

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Racial differences in bone loss and relation to menopause among HIV-infected and uninfected women., Anjali Sharma, Peter L Flom, Clifford J Rosen, and Ellie E Schoenbaum

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Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa., Pouneh K Fazeli, Alexander T Faje, Ela J Cross, Hang Lee, Clifford J Rosen, Mary L Bouxsein, and Anne Klibanski

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The effect of tonsillectomy on the immune system: a systematic review and meta-analysis., Mohamad A Bitar, Alexander Dowli, and Marc Mourad

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Tolerability and efficacy of 3 approaches to intra-articular corticosteroid injections of the knee for osteoarthritis: a randomized controlled trial., Bradford S Wagner, Allyson S Howe, William W Dexter, John R Hatzenbuehler, Christina Holt, Amy E Haskins, and F Lee Lucas

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Validation of the Patient-Reported Outcome Mortality Prediction Tool (PROMPT)., Christine W Duarte, Adam W Black, Kimberly Murray, Amy E Haskins, Lee Lucas, Sarah Hallen, and Paul K J Han