Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2015

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Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis., David T Paik, Meena Rai, Sergey Ryzhov, Lehanna N Sanders, Omonigho Aisagbonhi, Mitchell J Funke, Igor Feoktistov, and Antonis K Hatzopoulos

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Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia., Seth E Karol, Wenjian Yang, Sara L Van Driest, Tamara Y Chang, Sue Kaste, Erica Bowton, Melissa Basford, Lisa Bastarache, Dan M Roden, Joshua C Denny, Eric Larsen, Naomi Winick, William L Carroll, Cheng Cheng, Deqing Pei, Christian A Fernandez, Chengcheng Liu, Colton Smith, Mignon L Loh, Elizabeth A Raetz, Stephen P Hunger, Paul Scheet, Sima Jeha, Ching-Hon Pui, William E Evans, Meenakshi Devidas, Leonard A Mattano, and Mary V Relling

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Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia., Seth E Karol, Wenjian Yang, Sara L Van Driest, Tamara Y Chang, Sue Kaste, Erica Bowton, Melissa Basford, Lisa Bastarache, Dan M Roden, Joshua C Denny, Eric Larsen, Naomi Winick, William L Carroll, Cheng Cheng, Deqing Pei, Christian A Fernandez, Chengcheng Liu, Colton Smith, Mignon L Loh, Elizabeth A Raetz, Stephen P Hunger, Paul Scheet, Sima Jeha, Ching-Hon Pui, William E Evans, Meenakshi Devidas, Leonard A Mattano, and Mary V Relling

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Agitation in the Emergency Department: Importance of Schizophrenia and Related Disorders., T D. Strout and M R. Baumann

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Beyond Cavities and Emphysema., Akshu Balwan, Thomas Van der Kloot, and Jennifer Palminteri

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Closing the Treatment Gap for Cardiac Rehabilitation., Donna M Polk and Patrick T O'Gara

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Culture Conditions for Expansion of Nephron Progenitor Cells, Aaron C. Brown and Leif Oxburgh

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Does a Visual Cue Checklist Improve Communication and Adherence to Best Practices in the Emergency Critical Care Setting?, T D. Strout, S A. Haydar, and V Smith

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Effectiveness of regionalized systems for stroke and myocardial infarction., James P Rhudy, Marie A Bakitas, Kristiina Hyrkäs, Rita A Jablonski-Jaudon, Erica R Pryor, Henry E Wang, and Anne W Alexandrov

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Effects of personalized colorectal cancer risk information on laypersons' interest in colorectal cancer screening: The importance of individual differences., Paul K J Han, Christine W Duarte, Susannah Daggett, Andrea Siewers, Bill Killam, Kahsi A Smith, and Andrew N Freedman

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Enhancing Adolescent and Young Adult Oncology Research Within the National Clinical Trials Network: Rationale, Progress, and Emerging Strategies., Aaron R Weiss, Craig R Nichols, and David R Freyer

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Etomidate in sepsis: understanding the dilemma., David J Gagnon and David B Seder

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Genetic information-seeking behaviors and knowledge among family members and patients with inherited bone marrow failure syndromes., Jada G Hamilton, Sadie P Hutson, Amy E Frohnmayer, Paul K J Han, June A Peters, Ann G Carr, and Blanche P Alter

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Perceived ambiguity as a barrier to intentions to learn genome sequencing results., Jennifer M Taber, William M P Klein, Rebecca A Ferrer, Paul K J Han, Katie L Lewis, Leslie G Biesecker, and Barbara B Biesecker

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Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice., David A Hartmann, Robert G Underly, Roger I Grant, Ashley N Watson, Volkhard Lindner, and Andy Y Shih

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Pilot Evaluation of a Pulmonary Specialty-Based Lung Cancer Screening Program., Akshu Balwan, Paul Han, Caitlin Gutheil, Adam Black, Barbara Grillo, Sharon Siegel, Jason Yahwak, and Mayuko Fukunaga

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Recurrent human papillomavirus-related airway squamous cell carcinomas., Akshu Balwan, Hagen Blaszyk, and Thomas E Van der Kloot

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The use of haematopoietic stem cell transplantation in Fanconi anaemia patients: a survey of decision making among families in the US and Canada., Sadie P Hutson, Paul K J Han, Jada G Hamilton, Sean C Rife, Mohamad M Al-Rahawan, Richard P Moser, Seth P Duty, Sheeba Anand, and Blanche P Alter

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Treatment of arthritis associated with Legg-Calve-Perthes disease with modular total hip arthroplasty., Christopher R Seufert and Brian J McGrory

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Utility of the Modified “Surprise Question” for Predicting Inpatient Mortality in Emergency Department Patients., T D. Strout, S A. Haydar, P J.K. Han, and A G. Bond

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Expression of adenosine receptors in monocytes from patients with bronchial asthma., Ksenia Yuryeva, Irina Saltykova, Ludmila Ogorodova, Natalya Kirillova, Evgeny Kulikov, Elena Korotkaya, Yulia Iakovleva, Igor Feoktistov, Alexey Sazonov, and Sergey Ryzhov

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A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development., S Castillo-Lluva, L Hontecillas-Prieto, A Blanco-Gómez, M Del Mar Sáez-Freire, B García-Cenador, J García-Criado, M Pérez-Andrés, A Orfao, M Cañamero, J H Mao, T Gridley, A Castellanos-Martín, and J Pérez-Losada

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Adipose tissue residing progenitors (adipocyte lineage progenitors and adipose derived stem cells (ADSC)., Ryan Berry, Matthew S Rodeheffer, Clifford J Rosen, and Mark C Horowitz

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A high fat diet increases bone marrow adipose tissue (MAT) but does not alter trabecular or cortical bone mass in C57BL/6J mice., Casey R Doucette, Mark C Horowitz, Ryan Berry, Ormond A MacDougald, Rea Anunciado-Koza, Robert A Koza, and Clifford J Rosen

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Airway Management in Patients With Abnormal Anatomy or Challenging Physiology., Nathan W. Mick

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A phase II evaluation of cediranib in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group study., David Bender, Michael W Sill, Heather A Lankes, Henry D Reyes, Christopher J Darus, James E Delmore, Jacob Rotmensch, Heidi J Gray, Robert S Mannel, Jeanne M Schilder, Mark I Hunter, Carolyn K McCourt, Megan I Samuelson, and Kimberly K Leslie

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A phase II trial of trebananib (AMG 386; IND#111071), a selective angiopoietin 1/2 neutralizing peptibody, in patients with persistent/recurrent carcinoma of the endometrium: an NRG/Gynecologic Oncology Group trial., Kathleen N Moore, Michael W Sill, Meaghan E Tenney, Christopher J Darus, David Griffin, Theresa L Werner, Peter G Rose, and Robert Behrens

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Assessment of food intake, obesity, and health risk among the homeless in Rhode Island., Diane C Martins, Kathleen S Gorman, Robin J Miller, Leah Murphy, Sekboppa Sor, Jonah C Martins, and Maria L Vecchiarelli

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Carotid flow time changes with volume status in acute blood loss., David C Mackenzie, Noman A Khan, David Blehar, Scott Glazier, Yuchiao Chang, Christopher P Stowell, Vicki E Noble, and Andrew S Liteplo

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Cervical cancer screening and follow-up in 4 geographically diverse US health care systems, 1998 through 2007., Sheila Weinmann, Andrew E Williams, Aruna Kamineni, Diana S M Buist, Erin E Masterson, Natasha K Stout, Azadeh Stark, Tyler R Ross, Christopher L Owens, Terry S Field, and Chyke A Doubeni

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Evaluating adverse rural crash outcomes using the NHTSA State Data System., Christine Peura, Joseph A Kilch, and David E Clark

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From the Editor: The Journey to Open Access., Robert C Groom

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General Consideration in the History, Physical Examination, and Safety Determination., Jonathan Buchanan, William Dexter, Amy Powell, and Justin Wright

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Heart rate variables in the Vascular Quality Initiative are not reliable predictors of adverse cardiac outcomes or mortality after major elective vascular surgery., Salvatore Scali, Daniel Bertges, Daniel Neal, Virendra Patel, Jens Eldrup-Jorgensen, Jack Cronenwett, and Adam Beck

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High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes., Joshua C Anderson, Christopher D Willey, Amitkumar Mehta, Karim Welaya, Dongquan Chen, Christine W Duarte, Pooja Ghatalia, Waleed Arafat, Ankit Madan, Sunil Sudarshan, Gurudatta Naik, William E Grizzle, Toni K Choueiri, and Guru Sonpavde

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Large penile mass with unusual benign histopathology., Nate Johnson, Maria Voznesensky, and Graham VerLee

Paravertebral analgesia in transapical transcatheter aortic valve replacement., Justin M. Poltak, Frederick C. Cobey, John G. Augoustides, and Christopher W. Connors

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Pediatric professional medical associations and industry guideline compliance., Matthew Siegel, Amy Stedman, and Kahsi A Smith

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Predonation direct and indirect costs incurred by adults who donated a kidney: findings from the KDOC study., J R Rodrigue, J D Schold, P Morrissey, J Whiting, J Vella, L K Kayler, D Katz, J Jones, B Kaplan, A Fleishman, M Pavlakis, and D A Mandelbrot

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Preservation of multidimensional quality of life after endoscopic pituitary adenoma resection., Edward D McCoul, Jeffrey C Bedrosian, Olga Akselrod, Vijay K Anand, and Theodore H Schwartz

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Survival following Ommaya reservoir placement for neoplastic meningitis., Marie Roguski, Anand Rughani, Chih-Ta Lin, Deborah A Cushing, Jeffrey E Florman, and Julian K Wu

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Temporal changes in tolerance of uncertainty among medical students: insights from an exploratory study., Paul K J Han, Daniel Schupack, Susannah Daggett, Christina T Holt, and Tania D Strout

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The authors reply., David B Seder, Richard R Riker, and Niklas Nielsen

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Unraveling the function of FTO variants., Clifford J Rosen and Julie R Ingelfinger

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Urinary phenylacetylglutamine (U-PAGN) concentration as biomarker for adherence in patients with urea cycle disorders (UCD) treated with glycerol phenylbutyrate., M Mokhtarani, G A Diaz, U Lichter-Konecki, S A Berry, J Bartley, S E McCandless, W Smith, C Harding, C Le Mons, D F Coakley, B Lee, and B F Scharschmidt

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Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues., Erica L Scheller, Casey R Doucette, Brian S Learman, William P Cawthorn, Shaima Khandaker, Benjamin Schell, Brent Wu, Shi-Ying Ding, Miriam A Bredella, Pouneh K Fazeli, Basma Khoury, Karl J Jepsen, Paul F Pilch, Anne Klibanski, Clifford J Rosen, and Ormond A MacDougald

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AHNAK2 participates in the stress-induced nonclassical FGF1 secretion pathway., Aleksandr Kirov, Doreen Kacer, Barbara A Conley, Calvin P H Vary, and Igor Prudovsky

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Clean intermittent catheterization as an initial management strategy provides for adequate preservation of renal function in newborns with persistent cloaca., David J Chalmers, Kyle O Rove, Cole A Wiedel, Suhong Tong, Georgette L Siparsky, and Duncan T Wilcox

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Cthrc1 controls adipose tissue formation, body composition, and physical activity., J Patrizia Stohn, Qiaozeng Wang, Matthew E Siviski, Kevin Kennedy, Yong-Ri Jin, Doreen Kacer, Victoria DeMambro, Lucy Liaw, Calvin P Vary, Clifford J Rosen, Igor Prudovsky, and Volkhard Lindner

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Delivering a decision support intervention about PSA screening to patients outside of clinical encounters is ineffective in promoting informed decision-making., Paul K J Han

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Energy excess, glucose utilization, and skeletal remodeling: new insights., Beata Lecka-Czernik and Clifford J Rosen

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Myocardial infarction in the setting of anaphylaxis to celecoxib: a case of Kounis syndrome., Anthony C Regis, Carl A Germann, and Jacob G Crowell

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Point-of-care ultrasound education for non-physician clinicians in a resource-limited emergency department., Lori A Stolz, Krithika M Muruganandan, Mark C Bisanzo, Mugisha J Sebikali, Bradley A Dreifuss, Heather S Hammerstedt, Sara W Nelson, Irene Nayabale, Srikar Adhikari, and Sachita P Shah

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Racial differences in bone loss and relation to menopause among HIV-infected and uninfected women., Anjali Sharma, Peter L Flom, Clifford J Rosen, and Ellie E Schoenbaum

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Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa., Pouneh K Fazeli, Alexander T Faje, Ela J Cross, Hang Lee, Clifford J Rosen, Mary L Bouxsein, and Anne Klibanski

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The effect of tonsillectomy on the immune system: a systematic review and meta-analysis., Mohamad A Bitar, Alexander Dowli, and Marc Mourad

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Tolerability and efficacy of 3 approaches to intra-articular corticosteroid injections of the knee for osteoarthritis: a randomized controlled trial., Bradford S Wagner, Allyson S Howe, William W Dexter, John R Hatzenbuehler, Christina Holt, Amy E Haskins, and F Lee Lucas

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Validation of the Patient-Reported Outcome Mortality Prediction Tool (PROMPT)., Christine W Duarte, Adam W Black, Kimberly Murray, Amy E Haskins, Lee Lucas, Sarah Hallen, and Paul K J Han

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Parent stem cells can serve as niches for their daughter cells., Ana Pardo-Saganta, Purushothama Rao Tata, Brandon M Law, Borja Saez, Ryan Dz-Wei Chow, Mythili Prabhu, Thomas Gridley, and Jayaraj Rajagopal

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CXCR4 regulates extra-medullary myeloma through epithelial-mesenchymal-transition-like transcriptional activation., Aldo M Roccaro, Yuji Mishima, Antonio Sacco, Michele Moschetta, Yu-Tzu Tai, Jiantao Shi, Yong Zhang, Michaela R Reagan, Daisy Huynh, Yawara Kawano, Ilyas Sahin, Marco Chiarini, Salomon Manier, Michele Cea, Yosra Aljawai, Siobhan Glavey, Elizabeth Morgan, Chin Pan, Franziska Michor, Pina Cardarelli, Michelle Kuhne, and Irene M Ghobrial

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A synthetic niche for nephron progenitor cells., Aaron C Brown, Sree Deepthi Muthukrishnan, and Leif Oxburgh

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Social media use in research: engaging communities in cohort studies to support recruitment and retention., Eva Farina-Henry, Leo B Waterston, and Laura L Blaisdell

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Liberal or Restrictive Transfusion after Cardiac Surgery., Robert S Kramer, Robert C Groom, and Timothy E Hayes

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A high prevalence of corrosion at the head-neck taper with contemporary Zimmer non-cemented femoral hip components., Brian J McGrory, Johanna MacKenzie, and George Babikian

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Bathing frequency recommendations for children with atopic dermatitis: results of three observational pilot surveys., Ivan D Cardona, Erin Kempe, John R Hatzenbeuhler, Richard J Antaya, Bernard Cohen, and Neal Jain

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Blood ammonia and glutamine as predictors of hyperammonemic crises in patients with urea cycle disorder., Brendan Lee, George A Diaz, William Rhead, Uta Lichter-Konecki, Annette Feigenbaum, Susan A Berry, Cindy Le Mons, James A Bartley, Nicola Longo, Sandesh C Nagamani, William Berquist, Renata Gallagher, Dennis Bartholomew, Cary O Harding, Mark S Korson, Shawn E McCandless, Wendy Smith, Stephen Cederbaum, Derek Wong, J Lawrence Merritt, Andreas Schulze, Jerry Vockley, Gerard Vockley, David Kronn, Roberto Zori, Marshall Summar, Douglas A Milikien, Miguel Marino, Dion F Coakley, Masoud Mokhtarani, and Bruce F Scharschmidt

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Effects of False-Positive Cancer Screenings and Cancer Worry on Risk-Reducing Surgery Among BRCA1/2 Carriers., David B. Portnoy, Jennifer T. Loud, Paul K.J. Han, L. Mai Phoung, and Mark H. Green

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Family system interventions for families of children with autism spectrum disorder., Eric Goepfert, Christina Mulé, Erik von Hahn, Zachary Visco, and Matthew Siegel

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Images in emergency medicine. Woman with syncope. Twiddler's syndrome., Alison W Frizell and Casey Z MacVane

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In reply: stereotactic microanatomy of the nucleus accumbens stimulation for obsessive-compulsive disorder: reported coordinates and Mavridis' area., Clement Hamani, Julie Pilitsis, Anand I Rughani, Joshua M Rosenow, Parag G Patil, Konstantin Slavin, Aviva Abosch, Emad Eskandar, Laura Mitchell, and Steven Kalkanis

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Mycobacterium tuberculosis resistance in pulmonary TB patients in Cameroon: a phenotypic susceptibility assay., J Jubulis, K Dionne, G Osterhout, L Ayuk, C Awasom, P Achu, J Noeske, R Warren, C McArthur, and N Parrish

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Outcomes of comatose cardiac arrest survivors with and without ST-segment elevation myocardial infarction: importance of coronary angiography., Karl B Kern, Kapildeo Lotun, Nainesh Patel, Michael R Mooney, Ryan D Hollenbeck, John A McPherson, Paul W McMullan, Barbara Unger, Chiu-Hsieh Hsu, and David B Seder

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Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study 0229N., Vicky Makker, Virginia L Filiaci, Lee-May Chen, Christopher J Darus, James E Kendrick, Gregory Sutton, Katherine Moxley, and Carol Aghajanian

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Preoperative β-blockers do not improve cardiac outcomes after major elective vascular surgery and may be harmful., Salvatore Scali, Virendra Patel, Daniel Neal, Daniel Bertges, Karen Ho, Jens-Eldrup Jorgensen, Jack Cronenwett, and Adam Beck

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Prophylactic antibiotics are associated with a lower incidence of pneumonia in cardiac arrest survivors treated with targeted temperature management., David J Gagnon, Niklas Nielsen, Gilles L Fraser, Richard R Riker, John Dziodzio, Kjetil Sunde, Jan Hovdenes, Pascal Stammet, Hans Friberg, Sten Rubertsson, Michael Wanscher, and David B Seder

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Propranolol attenuates risperidone-induced trabecular bone loss in female mice., Katherine J Motyl, Victoria E DeMambro, Deborah Barlow, David Olshan, Kenichi Nagano, Roland Baron, Clifford J Rosen, and Karen L Houseknecht

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Sailing smoothly across the cultural divide., Linda Myerholtz, Julie Schirmer, and Mary Anne Carling

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Scrotal cystocele managed with trans-scrotal neocystostomy tube., Stephen T. Ryan and Brian Jumper

Senior Medical Students Perception of the Final Year of Medical School, the Impact of Faculty Advice., D Wald, H House, C Germann, M Fix, T Laack, D Yu, F Ramsey, and J Wen

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SLUG is a direct transcriptional repressor of PTEN tumor suppressor., Berna Uygur, Katrina Abramo, Evgenia Leikina, Calvin Vary, Lucy Liaw, and Wen-Shu Wu

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Successful eculizumab treatment of recurrent postpartum atypical hemolytic uremic syndrome after kidney transplantation., Katherine Garlo, Doug Dressel, Marizela Savic, and John Vella

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Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski

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Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski

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Aortoenteric fistula identified by clinical ultrasound., David C Mackenzie

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Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation., Matthew R Sanborn, Mark E Edsell, Meeri N Kim, Rickson Mesquita, Mary E Putt, Chris Imray, Heng Yow, Mark H Wilson, Arjun G Yodh, Mike Grocott, and Daniel S Martin

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Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast., Michaela R Reagan, Lucy Liaw, Clifford J Rosen, and Irene M Ghobrial

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Education and simulation training of pediatric intensive care unit nurses to care for open heart surgery patients., Jacqueline M Campbell

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Fibroblast growth factor signaling in the vasculature., Xuehui Yang, Lucy Liaw, Igor Prudovsky, Peter C Brooks, Calvin Vary, Leif Oxburgh, and Robert Friesel

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Hypertension, antihypertensive medications, and risk of incident primary hyperparathyroidism., Anand Vaidya, Gary C Curhan, Julie M Paik, Henry Kronenberg, and Eric N Taylor

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Pediatric papillary thyroid cancer >1 cm: is total thyroidectomy necessary?, Tate Nice, Sebastian Pasara, Melanie Goldfarb, John Doski, Adam Goldin, Kenneth W Gow, Jed G Nuchtern, Sanjeev A Vasudevan, Monica Langer, and Elizabeth A Beierle

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Reconsidering the effectiveness and safety of carotid sinus massage as a therapeutic intervention in patients with supraventricular tachycardia., Nikolas A Collins and George L Higgins

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Report from AmSECT's International Consortium for Evidence- Based Perfusion Consensus Statement: Minimal Criteria for Reporting Cardiopulmonary Bypass-Related Contributions to Red Blood Cell Transfusions Associated With Adult Cardiac Surgery., Donald S Likosky, Robert A Baker, Timothy A Dickinson, Daniel J FitzGerald, M Filip De Somer, Robert C Groom, David FitzGerald, Kenneth G Shann, Michael Poullis, Bruce D Spiess, Karim Jabr, Mark T Lucas, James D Ferguson, and Shahna L Bronson

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Retrograde tibiopedal access for the treatment of critical limb ischemia., Ethan M Dobrow and Derek Mittleider

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Severity of anemia predicts hospital length of stay but not readmission in patients with chronic kidney disease: a retrospective cohort study., Katherine Garlo, Deanna Williams, Lee Lucas, Rocket Wong, Joel Botler, Stuart Abramson, and Mark G Parker

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Sharp lower abdominal pain and calcified abdominal mass., Kristen Sihler, Michael Mazza, Lena M Napolitano, and David V Feliciano

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SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development., Jonathon Marks-Bluth, Anchit Khanna, Vashe Chandrakanthan, Julie Thoms, Thomas Bee, Christina Eich, Young Chan Kang, Kathy Knezevic, Qiao Qiao, Simon Fitch, Leif Oxburgh, Katrin Ottersbach, Elaine Dzierzak, Marella F T R de Bruijn, and John E Pimanda

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What does Quality Mean for Perfusionists?, Robert C Groom

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Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium., Katja Horvay, Thierry Jardé, Franca Casagranda, Victoria M Perreau, Katharina Haigh, Christian M Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J Haigh, Nick Barker, Jose M Polo, Gary R Hime, and Helen E Abud

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COCATS 4 Task Force 2: Training in Preventive Cardiovascular Medicine., Sidney C Smith, Vera Bittner, J Michael Gaziano, John C Giacomini, Quinn R Pack, Donna M Polk, Neil J Stone, and Stanley Wang

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Assessment of medical student and resident/fellow knowledge, comfort, and training with sexual history taking in LGBTQ patients., Victoria Hayes, Whitney Blondeau, and Robert G Bing-You