Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. MaineHealth Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2015

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Emergency medicine residents' knowledge of mechanical ventilation., Susan R Wilcox, Todd A Seigel, Tania D Strout, Jeffrey I Schneider, Patricia M Mitchell, Evie G Marcolini, Michael N Cocchi, Howard A Smithline, Lucienne Lutfy-Clayton, Marie Mullen, Jonathan S Ilgen, and Jeremy B Richards

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Methadone versus morphine for treatment of neonatal abstinence syndrome: a prospective randomized clinical trial., M S Brown, M J Hayes, and L M Thornton

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Noninvasive prenatal testing: the importance of pretest trisomy risk and posttest predictive values., Joseph R Wax, Renee Chard, Angelina Cartin, Christian Litton, Michael G Pinette, and F Lee Lucas

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p53 Enables metabolic fitness and self-renewal of nephron progenitor cells., Yuwen Li, Jiao Liu, Wencheng Li, Aaron Brown, Melody Baddoo, Marilyn Li, Thomas Carroll, Leif Oxburgh, Yumei Feng, and Zubaida Saifudeen

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Participation in the Vascular Quality Initiative is associated with improved perioperative medication use, which is associated with longer patient survival., Randall R De Martino, Andrew W Hoel, Adam W Beck, Jens Eldrup-Jorgensen, John W Hallett, Gilbert R Upchurch, Jack L Cronenwett, and Philip P Goodney

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Scapulothoracic fusion for low-energy intrathoracic scapula dislocation: a report of two cases., Donald P Endrizzi, Daniel J Shubert, and Raymond R White

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Serotonin syndrome following methylene blue administration during cardiothoracic surgery., Christina J Smith, Dorothy Wang, Anna Sgambelluri, Robert S Kramer, and David J Gagnon

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Success rates in pediatric WPW ablation are improved with 3-dimensional mapping systems compared with fluoroscopy alone: a multicenter study., Scott R Ceresnak, Anne M Dubin, Jeffrey J Kim, Santiago O Valdes, Steven B Fishberger, Ira Shetty, Frank Zimmerman, Ronn E Tanel, Michael R Epstein, Kara S Motonaga, Christine A Capone, Lynn Nappo, Gregory J Gates, and Robert H Pass

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Air contamination with bacteria in cystic fibrosis clinics: implications for prevention strategies., Jonathan B Zuckerman, Sarah A Clock, B Stephen Prato, James J McDevitt, Juyan Julia Zhou, Laurie W Leclair, F Lee Lucas, and Lisa Saiman

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"Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial": Erratum., William R. McFarlane, Bruce Levin, Lori Travis, F Lee Lucas, Sarah Lynch, Mary Verdi, Deanna Williams, Steven Adelsheim, Roderick Calkins, Cameron S. Carter, Barbara Cornblatt, Stephan F. Taylor, Andrea M. Auther, Bentson McFarland, Ryan Melton, Margaret Migliorati, Tara Niendam, J Daniel Ragland, Tamar Sale, Melina Salvador, and Elizabeth Spring

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Decisions about medication use and cancer screening across age groups in the United States., Kathleen M Fairfield, Bethany S Gerstein, Carrie A Levin, Vickie Stringfellow, Heidi R Wierman, and Mary McNaughton-Collins

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Distal hypospadias repair in infants without a postoperative stent., David J Chalmers, Georgette L Siparsky, Cole A Wiedel, and Duncan T Wilcox

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Gender differences in the person-activity fit for positive psychology interventions., R Bruce Thompson, Christine Peura, and William F. Gayton

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Hypertension, living kidney donors, and transplantation: where are we today?, Ana P Rossi and John P Vella

Paravertebral analgesia in transapical transcatheter aortic valve replacement., Justin M. Poltak, Frederick C. Cobey, John G. Augoustides, and Christopher W. Connors

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Physical activity, energy intake and the risk of incident kidney stones., Pietro Manuel Ferraro, Gary C Curhan, Mathew D Sorensen, Giovanni Gambaro, and Eric N Taylor

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SLEAP: a wake-up call to question the oversimplification of ICU delirium., Gilles L Fraser, David J Gagnon, and Richard R Riker

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The interface of child mental health and juvenile diabetes mellitus., Sandra L Fritsch, Mark W Overton, and Douglas R Robbins

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Transition from dexmedetomidine to enteral clonidine for ICU sedation: an observational pilot study., David J Gagnon, Richard R Riker, Elizabeth K Glisic, Andrew Kelner, Hilary M Perrey, and Gilles L Fraser

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Vaginal anomalies and atresia associated with imperforate anus: diagnosis and surgical management., Kartikey A Pandya, Hiroyuki Koga, Manabu Okawada, Arnold G Coran, Atsuyuki Yamataka, and Daniel H Teitelbaum

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Stones, bones, and cardiovascular groans., Eric N Taylor

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Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron., Nils O Lindström, Melanie L Lawrence, Sally F Burn, Jeanette A Johansson, Elvira R M Bakker, Rachel A Ridgway, C-Hong Chang, Michele J Karolak, Leif Oxburgh, Denis J Headon, Owen J Sansom, Ron Smits, Jamie A Davies, and Peter Hohenstein

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American Medical Society for Sports Medicine (AMSSM) position statement: interventional musculoskeletal ultrasound in sports medicine., Jonathan T Finnoff, Mederic M Hall, Erik Adams, David Berkoff, Andrew L Concoff, William Dexter, and Jay Smith

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American Medical Society for Sports Medicine (AMSSM) position statement: interventional musculoskeletal ultrasound in sports medicine., Jonathan T Finnoff, Mederic M Hall, Erik Adams, David Berkoff, Andrew L Concoff, William Dexter, and Jay Smith

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Bundled payments in orthopaedics., Adam J Rana and Kevin J Bozic

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Burden of hospital admissions and utilization of hospice care in metastatic prostate cancer patients., Jesse D Sammon, Rana R McKay, Simon P Kim, Akshay Sood, Shyam Sukumar, Matthew H Hayn, Jim C Hu, Adam S Kibel, Paul L Nguyen, James O Peabody, Fred Saad, Maxine Sun, Briony Varda, Mani Menon, Toni K Choueiri, and Quoc-Dien Trinh

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Decision making and cancer., Valerie F Reyna, Wendy L Nelson, Paul K Han, and Michael P Pignone

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Human parechovirus-3 encephalitis in two neonates: acute and follow-up magnetic resonance imaging and evaluation of central nervous system markers of inflammation., Amanda D Brownell, Thomas Q Reynolds, Brian Livingston, and Carol A McCarthy

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Key articles and guidelines in the management of patients undergoing cardiac surgery., Ian B Hollis, Douglas L Jennings, Carrie S Oliphant, William L Baker, Estella M Davis, J Erin Allender, Wesley R Zemrak, and Christopher Ensor

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Moderate-dose sedation and analgesia during targeted temperature management after cardiac arrest., Teresa L May, David B Seder, Gilles L Fraser, Philip Stone, Barbara McCrum, and Richard R Riker

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Prospective series of two hours supine rest after 4fr sheath-based diagnostic cerebral angiography: outcomes, productivity and cost., Scott L Zuckerman, Ritwik Bhatia, Crystiana Tsujiara, Christopher B Baker, Alex Szafran, Deborah Cushing, Judy Aiken, Marilyn Tracy, J Mocco, and Robert D Ecker

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The bone-fat interface: basic and clinical implications of marrow adiposity., Maureen J Devlin and Clifford J Rosen

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The Maine Adolescent Council on Transition (ACT Maine): A resident-driven, Community Access to Child Health (CATCH) Grant Funded Project to Improve the Quality of Health Care Transition and Build Resilience in Youth With Chronic Illness and Their..., Jack C. Rusley, Jessica Hunt, David Buzanoski, Renata Arrington-Sanders, Jonathan T. Fanburg, and Patrice Thibodeau

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Using vascular quality initiative as a platform for organizing multicenter, prospective, randomized clinical trials: OVERPAR trial., Mohammad H Eslami, Gheorghe Doros, Philip P Goodney, Jens Elderup-Jorgenson, Jack L Cronenwett, Marina Malikova, and Alik Farber

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Compositions and Methods for Treating Inflammation and Fibrosis, Peter C. Brooks, Leif Oxburgh, and Jennifer M. Caron

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3,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects?, Arturo Hernandez

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Analgesia, sedation, and neuromuscular blockade during targeted temperature management after cardiac arrest., Richard R Riker, David J Gagnon, Teresa May, David B Seder, and Gilles L Fraser

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A qualitative study of patient and family perceptions of chaplain presence during post-trauma care., Steven C McCormick and Alice A Hildebrand

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A young man with abdominal trauma and inability to void., Janessa D Leger, George L Higgins, and Matthew T Opacic

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Barriers to employment for drug dependent postpartum women., Kelley Bowden and Daisy Goodman

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BMP9 crosstalk with the hippo pathway regulates endothelial cell matricellular and chemokine responses., Kira Young, Eric Tweedie, Barbara Conley, Jacquelyn Ames, MaryLynn FitzSimons, Peter Brooks, Lucy Liaw, and Calvin P H Vary

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Changing Medicine and Building Community: Maine's Adverse Childhood Experiences Momentum., Leslie Forstadt, Sally Cooper, and Sue Mackey Andrews

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Characterizing participants in the ClinSeq genome sequencing cohort as early adopters of a new health technology., Katie L Lewis, Paul K J Han, Gillian W Hooker, William M P Klein, Leslie G Biesecker, and Barbara B Biesecker

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Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial., William R McFarlane, Bruce Levin, Lori Travis, F Lee Lucas, Sarah Lynch, Mary Verdi, Deanna Williams, Steven Adelsheim, Roderick Calkins, Cameron S Carter, Barbara Cornblatt, Stephan F Taylor, Andrea M Auther, Bentson McFarland, Ryan Melton, Margaret Migliorati, Tara Niendam, J Daniel Ragland, Tamara Sale, Melina Salvador, and Elizabeth Spring

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Current orthopaedic surgeon practices for nonarthroplasty treatment of osteoarthritis of adult hip and knee., Justin Chang, Brian J McGrory, Adam Rana, Michael W Becker, George M Babikian, Peter Guay, and Kahsi A Smith

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Emergency neurological life support: airway, ventilation, and sedation., David B Seder, Andy Jagoda, and Becky Riggs

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Evolution from electrophysiologic to hemodynamic monitoring: the story of left atrial and pulmonary artery pressure monitors., Deirdre M Mooney, Erik Fung, Rahul N Doshi, and David M Shavelle

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Identification of Emergency department patients with acute heart failure at low risk for 30-day adverse events: The STRATIFY decision tool., Sean P Collins, Cathy A Jenkins, Frank E Harrell, Dandan Liu, Karen F Miller, Christopher J Lindsell, Allen J Naftilan, John A McPherson, David J Maron, Douglas B Sawyer, Neal L Weintraub, Gregory J Fermann, Susan K Roll, Matthew Sperling, and Alan B Storrow

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Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo., Liangru W Contois, Abebe Akalu, Jennifer M Caron, Eric Tweedie, Alexandra Cretu, Terry Henderson, Lucy Liaw, Robert Friesel, Calvin Vary, and Peter C Brooks

Long-term tattooing as a manifestation of metallosis in acetabular liner wear-through: a report of two cases., Malcolm Creighton-Smith, Brian J. McGrory, and Ioana Tolocica

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Mortality related to acute illness and injury in rural Uganda: task shifting to improve outcomes., Stacey Chamberlain, Uwe Stolz, Bradley Dreifuss, Sara W Nelson, Heather Hammerstedt, Jovita Andinda, Samuel Maling, and Mark Bisanzo

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Noninvasive prenatal testing: impact on genetic counseling, invasive prenatal diagnosis, and trisomy 21 detection., Joseph R Wax, Angelina Cartin, Renée Chard, F Lee Lucas, and Michael G Pinette

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Operative indications in recurrent ileocolic intussusception., Jeremy G Fisher, Eric A Sparks, Christopher G B Turner, Justin D Klein, Elliot Pennington, Faraz A Khan, David Zurakowski, Emily T Durkin, Dario O Fauza, and Biren P Modi

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Paravertebral analgesia in transapical transcatheter aortic valve replacement., Justin M Poltak, Frederick C Cobey, John G Augoustides, and Christopher W Connors

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Pediatric primary care providers' perspectives regarding hospital discharge communication: a mixed methods analysis., JoAnna K Leyenaar, Lora Bergert, Leah A Mallory, Richard Engel, Caroline Rassbach, Mark Shen, Tess Woehrlen, David Cooperberg, and Daniel Coghlin

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Pediatric sutureless circumcision: an effective and cost efficient alternative., Maria Voznesensky, Christopher Mutter, Matthew Hayn, Thomas Kinkead, and Brian Jumper

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Prenatal aneuploidy screening using cell-free DNA., Joseph R Wax, Renée Chard, Christian Litton, and Michael G Pinette

Primary Site Predicts Grade for Gastroenteropancreatic Neuroendocrine Tumors., Timothy L. Fitzgerald, Catalina Mosquera, C Suzanne Lea, and Matthew Mcmullen

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Promoting a perception of quietness on a telemetry unit., Cecilia Inman

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PTHrp comes full circle in cancer biology., Anyonya R Guntur, Casey R Doucette, and Clifford J Rosen

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Sailing smoothly across the cultural divide: constructing effective behavioral science presentations for medical audiences., Linda Myerholtz, Julie Schirmer, and Mary Anne Carling

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Self-reported treatment-associated symptoms among patients with urea cycle disorders participating in glycerol phenylbutyrate clinical trials., Sandesh C S Nagamani, George A Diaz, William Rhead, Susan A Berry, Cynthia Le Mons, Uta Lichter-Konecki, James Bartley, Annette Feigenbaum, Andreas Schulze, Nicola Longo, William Berquist, Renata Gallagher, Dennis Bartholomew, Cary O Harding, Mark S Korson, Shawn E McCandless, Wendy Smith, Jerry Vockley, David Kronn, Robert Zori, Stephen Cederbaum, J Lawrence Merritt, Derek Wong, Dion F Coakley, Bruce F Scharschmidt, Klara Dickinson, Miguel Marino, Brendan H Lee, and Masoud Mokhtarani

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Successful eculizumab treatment of recurrent postpartum atypical hemolytic uremic syndrome after kidney transplantation., Katherine Garlo, Doug Dressel, Marizela Savic, and John Vella

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Symptomatic infundibulopelvic dysgenesis in an adolescent., Daniel Pitts, David Chalmers, and Brian Jumper

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The autism inpatient collection: methods and preliminary sample description., Matthew Siegel, Kahsi A Smith, Carla Mazefsky, Robin L Gabriels, Craig Erickson, Desmond Kaplan, Eric M Morrow, Logan Wink, and Susan L Santangelo

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Transparent reporting of data quality in distributed data networks., Michael G Kahn, Jeffrey S Brown, Alein T Chun, Bruce N Davidson, Daniella Meeker, Patrick B Ryan, Lisa M Schilling, Nicole G Weiskopf, Andrew E Williams, and Meredith Nahm Zozus

Submissions from 2014

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Syndrome of severe pain associated with a continuous bumetanide infusion., David Shisler, Thomas M Austin, Eric Delpire, Douglas B Sawyer, and Arvind K Pandey

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Inducible models of bone loss., Casey R Doucette and Clifford J Rosen

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Effects of a renal rehabilitation exercise program in patients with CKD: a randomized, controlled trial., Ana P Rossi, Debra D Burris, F Leslie Lucas, Gail A Crocker, and James C Wasserman

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Assessing volume status and fluid responsiveness in the emergency department., David C Mackenzie and Vicki E Noble

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Caffeine intake and the risk of kidney stones., Pietro Manuel Ferraro, Eric N Taylor, Giovanni Gambaro, and Gary C Curhan

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Circulating sclerostin associated with vertebral bone marrow fat in older men but not women., Yu-Heng Vivian Ma, Ann V Schwartz, Sigurdur Sigurdsson, Trisha F Hue, Thomas F Lang, Tamara B Harris, Clifford J Rosen, Eric Vittinghoff, Gudny Eiriksdottir, Alda M Hauksdottir, Kristin Siggeirsdottir, Gunnar Sigurdsson, Diana Oskarsdottir, Nicola Napoli, Lisa Palermo, Vilmundur Gudnason, and Xiaojuan Li

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Clinical monitoring scales in acute brain injury: assessment of coma, pain, agitation, and delirium., Richard R Riker and Jennifer E Fugate

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Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor., Srinivas Jayanthi, Karuppanan Muthusamy Kathir, Dakshinamurthy Rajalingam, Mercede Furr, Anna Daily, Ryan Thurman, Lindsay Rutherford, Reena Chandrashekar, Paul Adams, Igor Prudovsky, and Thallapuranam Krishnaswamy Suresh Kumar

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Evaluation of anesthetic technique on surgical site infections (SSIs) at a single institution., Craig S Curry, Kahsi A Smith, and John W Allyn

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How do research participants perceive "uncertainty" in genome sequencing?, Barbara B Biesecker, William Klein, Katie L Lewis, Tyler C Fisher, Martha Frances Wright, Leslie G Biesecker, and Paul K Han

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Implementation of the systems approach to improve a pharmacist-managed vancomycin dosing service., David J Gagnon, Russel Roberts, and Lynne Sylvia

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Improving patients' readiness for coronary artery bypass graft surgery., Kristine Chaisson, Mary Sanford, Richard A Boss, Bruce J Leavitt, Michael J Hearne, Cathy S Ross, Elaine M Olmstead, Robert S Kramer, Patricia Hofmaster, Cathy Mingo, Dennis Duquette, Elizabeth Maislen, Jean A Clark, Donald S Likosky, Susan R Horton, Gerald T O'Connor, and David J Malenka

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Individual differences in aversion to ambiguity regarding medical tests and treatments: association with cancer screening cognitions., Paul K J Han, Andrew E Williams, Amy Haskins, Caitlin Gutheil, F Lee Lucas, William M P Klein, and Kathleen M Mazor

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Outcomes and unmet need for neonatal surgery in a resource-limited environment: estimates of global health disparities from Kampala, Uganda., Raghav Badrinath, Nasser Kakembo, Phyllis Kisa, Monica Langer, Doruk Ozgediz, and John Sekabira

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Perceptions of cancer as a death sentence: prevalence and consequences., Richard P Moser, Jamie Arndt, Paul K Han, Erika A Waters, Marni Amsellem, and Bradford W Hesse

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Prognosis after cardiac arrest: time to rethink why, how, and when*., David B Seder

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Rationale and design of the Vitamin D and Type 2 Diabetes (D2d) study: a diabetes prevention trial., Anastassios G Pittas, Bess Dawson-Hughes, Patricia R Sheehan, Clifford J Rosen, James H Ware, William C Knowler, and Myrlene A Staten

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Safety, feasibility, and outcomes of induced hypothermia therapy following in-hospital cardiac arrest-evaluation of a large prospective registry*., Josef Dankiewicz, Simon Schmidbauer, Niklas Nielsen, Karl B Kern, Michael R Mooney, Pascal Stammet, Richard R Riker, Sten Rubertsson, David Seder, Ondrej Smid, Kjetil Sunde, Eldar Søreide, Barbara T Unger, and Hans Friberg

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The effect of hospital care on early survival after penetrating trauma., David E Clark, Peter C Doolittle, Robert J Winchell, and Rebecca A Betensky

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Wilderness Medical Society practice guidelines for the prevention and treatment of frostbite: 2014 update., Scott E McIntosh, Matthew Opacic, Luanne Freer, Colin K Grissom, Paul S Auerbach, George W Rodway, Amalia Cochran, Gordon G Giesbrecht, Marion McDevitt, Christopher H Imray, Eric L Johnson, Jennifer Dow, and Peter H Hackett

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Development of clinical models for predicting erectile function after localized prostate cancer treatment., Amy E Haskins, Paul K J Han, Frances L Lucas, Ian Bristol, and Moritz Hansen

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Cardiac myxoma as a mimic: a diagnostic challenge., Alison W Frizell and George L Higgins

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Diet and gene interactions influence the skeletal response to polyunsaturated fatty acids., Nicolas Bonnet, Emmanuel Somm, and Clifford J Rosen

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Framework for development of physician competencies in genomic medicine: report of the Competencies Working Group of the Inter-Society Coordinating Committee for Physician Education in Genomics., Bruce R Korf, Anna B Berry, Melvin Limson, Ali J Marian, Michael F Murray, P Pearl O'Rourke, Eugene R Passamani, Mary V Relling, John Tooker, Gregory J Tsongalis, and Laura L Rodriguez

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Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions., M Elena Martinez, Marika Charalambous, Aabida Saferali, Steven Fiering, Anna K Naumova, Donald St Germain, Anne C Ferguson-Smith, and Arturo Hernandez

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Images in emergency medicine. Infant with rash. Neonatal Lyme disease., Jonathan D Miller and George L Higgins

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Notch signal integration in the vasculature during remodeling., Bahman Rostama, Sarah M Peterson, Calvin P H Vary, and Lucy Liaw

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Perceptions of food-insecure HIV-positive adults participating in a food supplementation program in central Kenya., Murugi Ndirangu, Kevin Sztam, Muhsin Sheriff, Mark Hawken, Stephen Arpadi, Juma Rashid, Richard Deckelbaum, and Wafaa El-Sadr

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Peri-strut low-intensity areas in optical coherence tomography correlate with peri-strut inflammation and neointimal proliferation: an in-vivo correlation study in the familial hypercholesterolemic coronary swine model of in-stent restenosis., Armando Tellez, Maxwell E Afari, Piotr P Buszman, Paul Seifert, Yanping Cheng, Krzysztof Milewski, Jennifer C McGregor, Javier A Garza, Mary B Roberts, Geng Hua Yi, Greg L Kaluza, and Juan F Granada

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Promoting preconception, pregnancy, and postpartum care following bariatric surgery: a best practice planning toolkit for patients and their physicians., Joseph R Wax, Angelina Cartin, and Michael G Pinette

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Staying ahead of pertussis., Gary Rivard and Anthony Viera

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Successful treatment of eczema coxsackium with wet wrap therapy and low-dose topical corticosteroid., Victoria K Johnson, Jennifer L Hayman, Carol A McCarthy, and Ivan D Cardona

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Work climate, communication and culture--workforce issues and staff retention., Lynn Macken and Kristiina Hyrkas

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World Health Assembly Resolution 60.22. [corrected]., Heather Hammerstedt, Samuel Maling, Ronald Kasyaba, Bradley Dreifuss, Stacey Chamberlain, Sara Nelson, Mark Bisanzo, and Isaac Ezati