Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. MaineHealth Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2015

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Parent stem cells can serve as niches for their daughter cells., Ana Pardo-Saganta, Purushothama Rao Tata, Brandon M Law, Borja Saez, Ryan Dz-Wei Chow, Mythili Prabhu, Thomas Gridley, and Jayaraj Rajagopal

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CXCR4 regulates extra-medullary myeloma through epithelial-mesenchymal-transition-like transcriptional activation., Aldo M Roccaro, Yuji Mishima, Antonio Sacco, Michele Moschetta, Yu-Tzu Tai, Jiantao Shi, Yong Zhang, Michaela R Reagan, Daisy Huynh, Yawara Kawano, Ilyas Sahin, Marco Chiarini, Salomon Manier, Michele Cea, Yosra Aljawai, Siobhan Glavey, Elizabeth Morgan, Chin Pan, Franziska Michor, Pina Cardarelli, Michelle Kuhne, and Irene M Ghobrial

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A synthetic niche for nephron progenitor cells., Aaron C Brown, Sree Deepthi Muthukrishnan, and Leif Oxburgh

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Social media use in research: engaging communities in cohort studies to support recruitment and retention., Eva Farina-Henry, Leo B Waterston, and Laura L Blaisdell

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Liberal or Restrictive Transfusion after Cardiac Surgery., Robert S Kramer, Robert C Groom, and Timothy E Hayes

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A high prevalence of corrosion at the head-neck taper with contemporary Zimmer non-cemented femoral hip components., Brian J McGrory, Johanna MacKenzie, and George Babikian

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Bathing frequency recommendations for children with atopic dermatitis: results of three observational pilot surveys., Ivan D Cardona, Erin Kempe, John R Hatzenbeuhler, Richard J Antaya, Bernard Cohen, and Neal Jain

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Blood ammonia and glutamine as predictors of hyperammonemic crises in patients with urea cycle disorder., Brendan Lee, George A Diaz, William Rhead, Uta Lichter-Konecki, Annette Feigenbaum, Susan A Berry, Cindy Le Mons, James A Bartley, Nicola Longo, Sandesh C Nagamani, William Berquist, Renata Gallagher, Dennis Bartholomew, Cary O Harding, Mark S Korson, Shawn E McCandless, Wendy Smith, Stephen Cederbaum, Derek Wong, J Lawrence Merritt, Andreas Schulze, Jerry Vockley, Gerard Vockley, David Kronn, Roberto Zori, Marshall Summar, Douglas A Milikien, Miguel Marino, Dion F Coakley, Masoud Mokhtarani, and Bruce F Scharschmidt

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Effects of False-Positive Cancer Screenings and Cancer Worry on Risk-Reducing Surgery Among BRCA1/2 Carriers., David B. Portnoy, Jennifer T. Loud, Paul K.J. Han, L. Mai Phoung, and Mark H. Green

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Family system interventions for families of children with autism spectrum disorder., Eric Goepfert, Christina Mulé, Erik von Hahn, Zachary Visco, and Matthew Siegel

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Images in emergency medicine. Woman with syncope. Twiddler's syndrome., Alison W Frizell and Casey Z MacVane

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In reply: stereotactic microanatomy of the nucleus accumbens stimulation for obsessive-compulsive disorder: reported coordinates and Mavridis' area., Clement Hamani, Julie Pilitsis, Anand I Rughani, Joshua M Rosenow, Parag G Patil, Konstantin Slavin, Aviva Abosch, Emad Eskandar, Laura Mitchell, and Steven Kalkanis

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Mycobacterium tuberculosis resistance in pulmonary TB patients in Cameroon: a phenotypic susceptibility assay., J Jubulis, K Dionne, G Osterhout, L Ayuk, C Awasom, P Achu, J Noeske, R Warren, C McArthur, and N Parrish

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Outcomes of comatose cardiac arrest survivors with and without ST-segment elevation myocardial infarction: importance of coronary angiography., Karl B Kern, Kapildeo Lotun, Nainesh Patel, Michael R Mooney, Ryan D Hollenbeck, John A McPherson, Paul W McMullan, Barbara Unger, Chiu-Hsieh Hsu, and David B Seder

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Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study 0229N., Vicky Makker, Virginia L Filiaci, Lee-May Chen, Christopher J Darus, James E Kendrick, Gregory Sutton, Katherine Moxley, and Carol Aghajanian

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Preoperative β-blockers do not improve cardiac outcomes after major elective vascular surgery and may be harmful., Salvatore Scali, Virendra Patel, Daniel Neal, Daniel Bertges, Karen Ho, Jens-Eldrup Jorgensen, Jack Cronenwett, and Adam Beck

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Prophylactic antibiotics are associated with a lower incidence of pneumonia in cardiac arrest survivors treated with targeted temperature management., David J Gagnon, Niklas Nielsen, Gilles L Fraser, Richard R Riker, John Dziodzio, Kjetil Sunde, Jan Hovdenes, Pascal Stammet, Hans Friberg, Sten Rubertsson, Michael Wanscher, and David B Seder

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Propranolol attenuates risperidone-induced trabecular bone loss in female mice., Katherine J Motyl, Victoria E DeMambro, Deborah Barlow, David Olshan, Kenichi Nagano, Roland Baron, Clifford J Rosen, and Karen L Houseknecht

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Sailing smoothly across the cultural divide., Linda Myerholtz, Julie Schirmer, and Mary Anne Carling

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Scrotal cystocele managed with trans-scrotal neocystostomy tube., Stephen T. Ryan and Brian Jumper

Senior Medical Students Perception of the Final Year of Medical School, the Impact of Faculty Advice., D Wald, H House, C Germann, M Fix, T Laack, D Yu, F Ramsey, and J Wen

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SLUG is a direct transcriptional repressor of PTEN tumor suppressor., Berna Uygur, Katrina Abramo, Evgenia Leikina, Calvin Vary, Lucy Liaw, and Wen-Shu Wu

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Successful eculizumab treatment of recurrent postpartum atypical hemolytic uremic syndrome after kidney transplantation., Katherine Garlo, Doug Dressel, Marizela Savic, and John Vella

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Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski

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Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski

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Aortoenteric fistula identified by clinical ultrasound., David C Mackenzie

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Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation., Matthew R Sanborn, Mark E Edsell, Meeri N Kim, Rickson Mesquita, Mary E Putt, Chris Imray, Heng Yow, Mark H Wilson, Arjun G Yodh, Mike Grocott, and Daniel S Martin

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Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast., Michaela R Reagan, Lucy Liaw, Clifford J Rosen, and Irene M Ghobrial

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Education and simulation training of pediatric intensive care unit nurses to care for open heart surgery patients., Jacqueline M Campbell

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Fibroblast growth factor signaling in the vasculature., Xuehui Yang, Lucy Liaw, Igor Prudovsky, Peter C Brooks, Calvin Vary, Leif Oxburgh, and Robert Friesel

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Hypertension, antihypertensive medications, and risk of incident primary hyperparathyroidism., Anand Vaidya, Gary C Curhan, Julie M Paik, Henry Kronenberg, and Eric N Taylor

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Pediatric papillary thyroid cancer >1 cm: is total thyroidectomy necessary?, Tate Nice, Sebastian Pasara, Melanie Goldfarb, John Doski, Adam Goldin, Kenneth W Gow, Jed G Nuchtern, Sanjeev A Vasudevan, Monica Langer, and Elizabeth A Beierle

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Reconsidering the effectiveness and safety of carotid sinus massage as a therapeutic intervention in patients with supraventricular tachycardia., Nikolas A Collins and George L Higgins

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Report from AmSECT's International Consortium for Evidence- Based Perfusion Consensus Statement: Minimal Criteria for Reporting Cardiopulmonary Bypass-Related Contributions to Red Blood Cell Transfusions Associated With Adult Cardiac Surgery., Donald S Likosky, Robert A Baker, Timothy A Dickinson, Daniel J FitzGerald, M Filip De Somer, Robert C Groom, David FitzGerald, Kenneth G Shann, Michael Poullis, Bruce D Spiess, Karim Jabr, Mark T Lucas, James D Ferguson, and Shahna L Bronson

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Retrograde tibiopedal access for the treatment of critical limb ischemia., Ethan M Dobrow and Derek Mittleider

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Severity of anemia predicts hospital length of stay but not readmission in patients with chronic kidney disease: a retrospective cohort study., Katherine Garlo, Deanna Williams, Lee Lucas, Rocket Wong, Joel Botler, Stuart Abramson, and Mark G Parker

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Sharp lower abdominal pain and calcified abdominal mass., Kristen Sihler, Michael Mazza, Lena M Napolitano, and David V Feliciano

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SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development., Jonathon Marks-Bluth, Anchit Khanna, Vashe Chandrakanthan, Julie Thoms, Thomas Bee, Christina Eich, Young Chan Kang, Kathy Knezevic, Qiao Qiao, Simon Fitch, Leif Oxburgh, Katrin Ottersbach, Elaine Dzierzak, Marella F T R de Bruijn, and John E Pimanda

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What does Quality Mean for Perfusionists?, Robert C Groom

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Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium., Katja Horvay, Thierry Jardé, Franca Casagranda, Victoria M Perreau, Katharina Haigh, Christian M Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J Haigh, Nick Barker, Jose M Polo, Gary R Hime, and Helen E Abud

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COCATS 4 Task Force 2: Training in Preventive Cardiovascular Medicine., Sidney C Smith, Vera Bittner, J Michael Gaziano, John C Giacomini, Quinn R Pack, Donna M Polk, Neil J Stone, and Stanley Wang

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Assessment of medical student and resident/fellow knowledge, comfort, and training with sexual history taking in LGBTQ patients., Victoria Hayes, Whitney Blondeau, and Robert G Bing-You

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Combined volume reduction with the loop-and-leave technique permits safe endoscopic management of high-risk giant gastric polyps., Suraj Gupta, Joshua Penfield, David Klibansy, and Douglas A. Howell

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Development of an algorithm to classify colonoscopy indication from coded health care data., Kenneth F. Adams, Eric A. Johnson, Jessica Chubak, Aruna Kamineni, Chyke A. Doubeni, Diana S M Buist, Andrew E. Williams, Sheila Weinmann, V Paul Doria-Rose, and Carolyn M. Rutter

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Gonadotropin-releasing hormone agonist use to guide diagnosis and treatment of autoimmune progesterone dermatitis., Amy Domeyer-Klenske, Diana Robillard, John Pulvino, and Daniel Spratt

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Let's Go! School nutrition workgroups: regional partnerships for improving school meals., Heidi L Kessler, Jackie Vine, and Victoria W Rogers

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Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors., Ana Villarejo, Patricia Molina-Ortiz, Yenny Montenegro, Gema Moreno-Bueno, Saleta Morales, Vanesa Santos, Tom Gridley, Mirna A Pérez-Moreno, Héctor Peinado, Francisco Portillo, Carmela Calés, and Amparo Cano

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Mo1380 Early ERCP Placement of Short Self-Expanding Metal Biliary Stents (SSEMS) in Locally-Advanced Pancreatic Cancer With Biliary Obstruction Improves Success and Outcomes of Neoadjuvant Therapy., Suraj Gupta, John Walker, Hani Jarawan, Lewis B. Richards, David Klibanksy, Douglas A. Howell, Justin Wilkes, Gina Z. Blaszyk, and Lisa A. Rutstein

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Neurologic outcomes and postresuscitation care of patients with myoclonus following cardiac arrest., David B Seder, Kjetil Sunde, Sten Rubertsson, Michael Mooney, Pascal Stammet, Richard R Riker, Karl B Kern, Barbara Unger, Tobias Cronberg, John Dziodzio, and Niklas Nielsen

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Prognostic significance of tumor mitotic rate in T2 melanoma staged with sentinel lymphadenectomy., Justin J Baker, Michael O Meyers, Allison M Deal, Jill F Frank, Karyn B Stitzenberg, and David W Ollila

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Review of Smashed: Story of a drunken girlhood., Sandra L. Fritsch

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Su1622 Cannulation of Intradiverticular Papillae At ERCP: a Successful Stepwise Approach Using Advanced Techniques., Hani Jarawan, Suraj Gupta, John Walker, Joshua Penfield, and Douglas A. Howell

Submersion and Drowning Injuries., Sara W. Nelson and Scott C. McCorvey

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Tu1731 Safe Definitive Endoscopic Management of High-Risk Polypoid Lesions of the Foregut Using Combined Volume Reduction and the Loop and Leave Technique., John Walker, Suraj Gupta, Hani Jarawan, Joshua Penfield, David Klibansky, and Douglas A. Howell

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Association of gender to outcome after out-of-hospital cardiac arrest--a report from the International Cardiac Arrest Registry., Viktor Karlsson, Josef Dankiewicz, Niklas Nielsen, Karl B Kern, Michael R Mooney, Richard R Riker, Sten Rubertsson, David B Seder, Pascal Stammet, Kjetil Sunde, Eldar Søreide, Barbara T Unger, and Hans Friberg

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Prevalence and risk factors for patient-reported joint pain among patients with HIV/hepatitis C coinfection, hepatitis C monoinfection, and HIV monoinfection., Alexis Ogdie, Wyki Gina Pang, Kimberly A Forde, Bhangle D Samir, Lakeisha Mulugeta, Kyong-Mi Chang, David E Kaplan, Valerianna K Amorosa, Jay R Kostman, Rajender K Reddy, Ralph H Schumacher, and Vincent Lo Re

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Calcium and phosphorus regulatory hormones and risk of incident symptomatic kidney stones., Eric N Taylor, Andrew N Hoofnagle, and Gary C Curhan

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A phase I feasibility study of multi-modality imaging assessing rapid expansion of marrow fat and decreased bone mineral density in cancer patients., Susanta K Hui, Luke Arentsen, Thanasak Sueblinvong, Keenan Brown, Pat Bolan, Rahel G Ghebre, Levi Downs, Ryan Shanley, Karen E Hansen, Anne G Minenko, Yutaka Takhashi, Masashi Yagi, Yan Zhang, Melissa Geller, Margaret Reynolds, Chung K Lee, Anne H Blaes, Sharon Allen, Bruno Beomonte Zobel, Chap Le, Jerry Froelich, Clifford Rosen, and Douglas Yee

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A structured teaching curriculum for medical students improves their performance on the National Board of Medical Examiners shelf examination in surgery., Keith Wirth, Bethany Malone, Christopher Turner, Robert Schulze, Warren Widmann, and Aliu Sanni

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Emergency medicine residents' knowledge of mechanical ventilation., Susan R Wilcox, Todd A Seigel, Tania D Strout, Jeffrey I Schneider, Patricia M Mitchell, Evie G Marcolini, Michael N Cocchi, Howard A Smithline, Lucienne Lutfy-Clayton, Marie Mullen, Jonathan S Ilgen, and Jeremy B Richards

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Methadone versus morphine for treatment of neonatal abstinence syndrome: a prospective randomized clinical trial., M S Brown, M J Hayes, and L M Thornton

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Noninvasive prenatal testing: the importance of pretest trisomy risk and posttest predictive values., Joseph R Wax, Renee Chard, Angelina Cartin, Christian Litton, Michael G Pinette, and F Lee Lucas

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p53 Enables metabolic fitness and self-renewal of nephron progenitor cells., Yuwen Li, Jiao Liu, Wencheng Li, Aaron Brown, Melody Baddoo, Marilyn Li, Thomas Carroll, Leif Oxburgh, Yumei Feng, and Zubaida Saifudeen

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Participation in the Vascular Quality Initiative is associated with improved perioperative medication use, which is associated with longer patient survival., Randall R De Martino, Andrew W Hoel, Adam W Beck, Jens Eldrup-Jorgensen, John W Hallett, Gilbert R Upchurch, Jack L Cronenwett, and Philip P Goodney

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Scapulothoracic fusion for low-energy intrathoracic scapula dislocation: a report of two cases., Donald P Endrizzi, Daniel J Shubert, and Raymond R White

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Serotonin syndrome following methylene blue administration during cardiothoracic surgery., Christina J Smith, Dorothy Wang, Anna Sgambelluri, Robert S Kramer, and David J Gagnon

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Success rates in pediatric WPW ablation are improved with 3-dimensional mapping systems compared with fluoroscopy alone: a multicenter study., Scott R Ceresnak, Anne M Dubin, Jeffrey J Kim, Santiago O Valdes, Steven B Fishberger, Ira Shetty, Frank Zimmerman, Ronn E Tanel, Michael R Epstein, Kara S Motonaga, Christine A Capone, Lynn Nappo, Gregory J Gates, and Robert H Pass

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Air contamination with bacteria in cystic fibrosis clinics: implications for prevention strategies., Jonathan B Zuckerman, Sarah A Clock, B Stephen Prato, James J McDevitt, Juyan Julia Zhou, Laurie W Leclair, F Lee Lucas, and Lisa Saiman

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"Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial": Erratum., William R. McFarlane, Bruce Levin, Lori Travis, F Lee Lucas, Sarah Lynch, Mary Verdi, Deanna Williams, Steven Adelsheim, Roderick Calkins, Cameron S. Carter, Barbara Cornblatt, Stephan F. Taylor, Andrea M. Auther, Bentson McFarland, Ryan Melton, Margaret Migliorati, Tara Niendam, J Daniel Ragland, Tamar Sale, Melina Salvador, and Elizabeth Spring

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Decisions about medication use and cancer screening across age groups in the United States., Kathleen M Fairfield, Bethany S Gerstein, Carrie A Levin, Vickie Stringfellow, Heidi R Wierman, and Mary McNaughton-Collins

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Distal hypospadias repair in infants without a postoperative stent., David J Chalmers, Georgette L Siparsky, Cole A Wiedel, and Duncan T Wilcox

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Gender differences in the person-activity fit for positive psychology interventions., R Bruce Thompson, Christine Peura, and William F. Gayton

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Hypertension, living kidney donors, and transplantation: where are we today?, Ana P Rossi and John P Vella

Paravertebral analgesia in transapical transcatheter aortic valve replacement., Justin M. Poltak, Frederick C. Cobey, John G. Augoustides, and Christopher W. Connors

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Physical activity, energy intake and the risk of incident kidney stones., Pietro Manuel Ferraro, Gary C Curhan, Mathew D Sorensen, Giovanni Gambaro, and Eric N Taylor

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SLEAP: a wake-up call to question the oversimplification of ICU delirium., Gilles L Fraser, David J Gagnon, and Richard R Riker

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The interface of child mental health and juvenile diabetes mellitus., Sandra L Fritsch, Mark W Overton, and Douglas R Robbins

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Transition from dexmedetomidine to enteral clonidine for ICU sedation: an observational pilot study., David J Gagnon, Richard R Riker, Elizabeth K Glisic, Andrew Kelner, Hilary M Perrey, and Gilles L Fraser

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Vaginal anomalies and atresia associated with imperforate anus: diagnosis and surgical management., Kartikey A Pandya, Hiroyuki Koga, Manabu Okawada, Arnold G Coran, Atsuyuki Yamataka, and Daniel H Teitelbaum

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Stones, bones, and cardiovascular groans., Eric N Taylor

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Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron., Nils O Lindström, Melanie L Lawrence, Sally F Burn, Jeanette A Johansson, Elvira R M Bakker, Rachel A Ridgway, C-Hong Chang, Michele J Karolak, Leif Oxburgh, Denis J Headon, Owen J Sansom, Ron Smits, Jamie A Davies, and Peter Hohenstein

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American Medical Society for Sports Medicine (AMSSM) position statement: interventional musculoskeletal ultrasound in sports medicine., Jonathan T Finnoff, Mederic M Hall, Erik Adams, David Berkoff, Andrew L Concoff, William Dexter, and Jay Smith

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American Medical Society for Sports Medicine (AMSSM) position statement: interventional musculoskeletal ultrasound in sports medicine., Jonathan T Finnoff, Mederic M Hall, Erik Adams, David Berkoff, Andrew L Concoff, William Dexter, and Jay Smith

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Bundled payments in orthopaedics., Adam J Rana and Kevin J Bozic

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Burden of hospital admissions and utilization of hospice care in metastatic prostate cancer patients., Jesse D Sammon, Rana R McKay, Simon P Kim, Akshay Sood, Shyam Sukumar, Matthew H Hayn, Jim C Hu, Adam S Kibel, Paul L Nguyen, James O Peabody, Fred Saad, Maxine Sun, Briony Varda, Mani Menon, Toni K Choueiri, and Quoc-Dien Trinh

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Decision making and cancer., Valerie F Reyna, Wendy L Nelson, Paul K Han, and Michael P Pignone

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Human parechovirus-3 encephalitis in two neonates: acute and follow-up magnetic resonance imaging and evaluation of central nervous system markers of inflammation., Amanda D Brownell, Thomas Q Reynolds, Brian Livingston, and Carol A McCarthy

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Key articles and guidelines in the management of patients undergoing cardiac surgery., Ian B Hollis, Douglas L Jennings, Carrie S Oliphant, William L Baker, Estella M Davis, J Erin Allender, Wesley R Zemrak, and Christopher Ensor

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Moderate-dose sedation and analgesia during targeted temperature management after cardiac arrest., Teresa L May, David B Seder, Gilles L Fraser, Philip Stone, Barbara McCrum, and Richard R Riker

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Prospective series of two hours supine rest after 4fr sheath-based diagnostic cerebral angiography: outcomes, productivity and cost., Scott L Zuckerman, Ritwik Bhatia, Crystiana Tsujiara, Christopher B Baker, Alex Szafran, Deborah Cushing, Judy Aiken, Marilyn Tracy, J Mocco, and Robert D Ecker

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The bone-fat interface: basic and clinical implications of marrow adiposity., Maureen J Devlin and Clifford J Rosen

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The Maine Adolescent Council on Transition (ACT Maine): A resident-driven, Community Access to Child Health (CATCH) Grant Funded Project to Improve the Quality of Health Care Transition and Build Resilience in Youth With Chronic Illness and Their..., Jack C. Rusley, Jessica Hunt, David Buzanoski, Renata Arrington-Sanders, Jonathan T. Fanburg, and Patrice Thibodeau

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Using vascular quality initiative as a platform for organizing multicenter, prospective, randomized clinical trials: OVERPAR trial., Mohammad H Eslami, Gheorghe Doros, Philip P Goodney, Jens Elderup-Jorgenson, Jack L Cronenwett, Marina Malikova, and Alik Farber

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Compositions and Methods for Treating Inflammation and Fibrosis, Peter C. Brooks, Leif Oxburgh, and Jennifer M. Caron

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3,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects?, Arturo Hernandez

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Analgesia, sedation, and neuromuscular blockade during targeted temperature management after cardiac arrest., Richard R Riker, David J Gagnon, Teresa May, David B Seder, and Gilles L Fraser

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A qualitative study of patient and family perceptions of chaplain presence during post-trauma care., Steven C McCormick and Alice A Hildebrand

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A young man with abdominal trauma and inability to void., Janessa D Leger, George L Higgins, and Matthew T Opacic

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Barriers to employment for drug dependent postpartum women., Kelley Bowden and Daisy Goodman

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BMP9 crosstalk with the hippo pathway regulates endothelial cell matricellular and chemokine responses., Kira Young, Eric Tweedie, Barbara Conley, Jacquelyn Ames, MaryLynn FitzSimons, Peter Brooks, Lucy Liaw, and Calvin P H Vary