Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2014

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Legalization of medical marijuana and incidence of opioid mortality., Marie J Hayes and Mark S Brown

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Life without the iodothyronine deiodinases., Valerie Anne Galton, Ellis de Waard, Albert F Parlow, Donald L St Germain, and Arturo Hernandez

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Prenatal sonographic diagnosis of placenta accreta--impact on maternal and neonatal outcomes., Tania Hall, Joseph R Wax, F Lee Lucas, Angelina Cartin, Michael Jones, and Michael G Pinette

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Retinaldehyde dehydrogenase 1 deficiency inhibits PPARγ-mediated bone loss and marrow adiposity., Shriram Nallamshetty, Phuong T Le, Hong Wang, Maya J Issacsohn, David J Reeder, Eun-Jung Rhee, Florian W Kiefer, Jonathan D Brown, Clifford J Rosen, and Jorge Plutzky

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The development of sustainable emergency care in Ghana: physician, nursing and prehospital care training initiatives., John Martel, Rockefeller Oteng, Nee-Kofi Mould-Millman, Sue Anne Bell, Ahmed Zakariah, George Oduro, Terry Kowalenko, and Peter Donkor

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Teaching and addressing health disparities through the family medicine social and community context of care project., Jordan White, Jessica Heney, Angela Y Esquibel, Camia Dimock, Roberta Goldman, and David Anthony

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Brief report: serpin Spi2A as a novel modulator of hematopoietic progenitor cell formation., Lei Li, Susan M Byrne, Nicole Rainville, Su Su, Edward Jachimowicz, Anne Aucher, Daniel M Davis, Philip G Ashton-Rickardt, and Don M Wojchowski

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Does early second-trimester sonography predict adverse perinatal outcomes in monochorionic diamniotic twin pregnancies?, M Baraa Allaf, Winston A Campbell, Anthony M Vintzileos, Sina Haeri, Pouya Javadian, Amir A Shamshirsaz, Paul Ogburn, Reinaldo Figueroa, Joseph Wax, Glenn Markenson, Martin R Chavez, Samadh F Ravangard, Rodrigo Ruano, Haleh Sangi-Haghpeykar, Bahram Salmanian, Marjorie Meyer, Jeffery Johnson, Ali Ozhand, Sarah Davis, Adam Borgida, Michael A Belfort, and Alireza A Shamshirsaz

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FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice., Sheila Bornstein, Sue A Brown, Phuong T Le, Xunde Wang, Victoria DeMambro, Mark C Horowitz, Ormond MacDougald, Roland Baron, Sutada Lotinun, Gerard Karsenty, Wei Wei, Mathieu Ferron, Christopher S Kovacs, David Clemmons, Yihong Wan, and Clifford J Rosen

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Intraperitoneal chemotherapy among women in the Medicare population with epithelial ovarian cancer., Kathleen M Fairfield, Kimberly Murray, Jason A LaChance, Heidi R Wierman, Craig C Earle, Edward L Trimble, and Joan L Warren

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Lack of shared decision making in cancer screening discussions: results from a national survey., Richard M Hoffman, Joann G Elmore, Kathleen M Fairfield, Bethany S Gerstein, Carrie A Levin, and Michael P Pignone

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Marrow fat composition in anorexia nervosa., Miriam A Bredella, Pouneh K Fazeli, Scott M Daley, Karen K Miller, Clifford J Rosen, Anne Klibanski, and Martin Torriani

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PACES/HRS expert consensus statement on the evaluation and management of ventricular arrhythmias in the child with a structurally normal heart., Jane E Crosson, David J Callans, David J Bradley, Anne Dubin, Michael Epstein, Susan Etheridge, Andrew Papez, John R Phillips, Larry A Rhodes, Philip Saul, Elizabeth Stephenson, William Stevenson, and Frank Zimmerman

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Reducing contrast-induced acute kidney injury using a regional multicenter quality improvement intervention., Jeremiah R Brown, Richard J Solomon, Mark J Sarnak, Peter A McCullough, Mark E Splaine, Louise Davies, Cathy S Ross, Harold L Dauerman, Janette L Stender, Sheila M Conley, John F Robb, Kristine Chaisson, Richard Boss, Peggy Lambert, David J Goldberg, Deborah Lucier, Frank A Fedele, Mirle A Kellett, Susan Horton, William J Phillips, Cynthia Downs, Alan Wiseman, Todd A MacKenzie, and David J Malenka

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Time Out., Robert C Groom

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RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development., Rakesh Verma, Su Su, Donald J McCrann, Jennifer M Green, Karen Leu, Peter R Young, Peter J Schatz, Jeffrey C Silva, Matthew P Stokes, and Don M Wojchowski

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Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction., William P Cawthorn, Erica L Scheller, Brian S Learman, Sebastian D Parlee, Becky R Simon, Hiroyuki Mori, Xiaomin Ning, Adam J Bree, Benjamin Schell, David T Broome, Sandra S Soliman, Jenifer L DelProposto, Carey N Lumeng, Aditi Mitra, Sandeep V Pandit, Katherine A Gallagher, Joshua D Miller, Venkatesh Krishnan, Susanta K Hui, Miriam A Bredella, Pouneh K Fazeli, Anne Klibanski, Mark C Horowitz, Clifford J Rosen, and Ormond A MacDougald

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Feasibility of bispectral index monitoring to guide early post-resuscitation cardiac arrest triage., David B Seder, John Dziodzio, Kahsi A Smith, Paige Hickey, Brittany Bolduc, Philip Stone, Teresa May, Barbara McCrum, Gilles L Fraser, and Richard R Riker

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Life-space assessment and physical activity scale for the elderly: validity of proxy informant responses., James T Cavanaugh and Kelley Crawford

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Lightening up a notch: notch regulation of energy metabolism., Thomas Gridley and Shingo Kajimura

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Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis., Mayrin C Medina, Tatiana L Fonesca, Judith Molina, Alberto Fachado, Melany Castillo, Liping Dong, Renata Soares, Arturo Hernández, Alejandro Caicedo, and Antonio C Bianco

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Parental social responsiveness and risk of autism spectrum disorder in offspring., Kristen Lyall, John N Constantino, Marc G Weisskopf, Andrea L Roberts, Alberto Ascherio, and Susan L Santangelo

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Systematic review: surgery for patients with metastatic melanoma during active treatment with ipilimumab., Justin J Baker, Karyn B Stitzenberg, Frances A Collichio, Michael O Meyers, and David W Ollila

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The 5'-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone., Valerie Anne Galton, Arturo Hernandez, and Donald L St Germain

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Erythroid mRNA processing: a "splice of life"., Don M Wojchowski

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Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis., Seung-Hun Lee, Sungsu Lee, Hanseul Yang, Sukhyun Song, Kangsan Kim, Thomas L Saunders, Jeong K Yoon, Gou Young Koh, and Injune Kim

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A systematic review of smoking cessation interventions in the emergency setting., Jonathan H Pelletier, Tania D Strout, and Michael R Baumann

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Injury and illness sustained by human competitors in the 2010 iditarod sled dog race., James W Gallea, George L Higgins, Carl A Germann, and Tania D Strout

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International Robotic Radical Cystectomy Consortium: A way forward., Syed Johar Raza, Erinn Field, Adam S Kibel, Alex Mottrie, Alon Z Weizer, Andrew Wagner, Ashok K Hemal, Douglas S Scherr, Francis Schanne, Franco Gaboardi, Guan Wu, James O Peabody, Jihad Koauk, Joan Palou Redorta, John G Pattaras, Koon-Ho Rha, Lee Richstone, M Derya Balbay, Mani Menon, Mathew Hayn, Micheal Stoeckle, Peter Wiklund, Prokar Dasgupta, Raj Pruthi, Reza Ghavamian, Shamim Khan, Stephan Siemer, Thomas Maatman, Timothy Wilson, Vassilis Poulakis, Greg Wilding, and Khurshid A Guru

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Psychometric testing of the Agitation Severity Scale for acute presentation behavioral management patients in the emergency department., Tania D Strout

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Retention, fatigue, burnout and job satisfaction: new aspects and challenges., Lynn Macken and Kristiina Hyrkas

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Thoracoscopic lobectomy is associated with acceptable morbidity and mortality in patients with predicted postoperative forced expiratory volume in 1 second or diffusing capacity for carbon monoxide less than 40% of normal., Bryan M Burt, Andrzej S Kosinski, Joseph B Shrager, Mark W Onaitis, and Tracey Weigel

Unfreezing the Flexnerian Model: introducing longitudinal integrated clerkships in rural communities., R G. Bing-You, T L. Trowbridge, C Kruithoff, and J L. Daggett Jr

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Women's Center Staff Perceptions of the Campus Climate on Sexual Violence., Tania Strout, Angela Frederick Amar, and Krystal Astwood

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Death associated protein kinase 2 is expressed in cortical interstitial cells of the mouse kidney., Justin A Guay, Don M Wojchowski, Jing Fang, and Leif Oxburgh

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Propagating the nephrology research workforce: a Kidney Research National Dialogue training commentary., Donald E Kohan, Mark G Parker, Susan L Furth, Billy G Hudson, Karen M Warburton, Krystyna E Rys-Sikora, and Tracy L Rankin

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Clinical impact of sacroplasty on patient mobility., Jennifer Talmadge, Kahsi Smith, Thomas Dykes, and Derek Mittleider

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Endovascular reconstruction of vertebral artery occlusion prior to basilar thrombectomy in a series of six patients presenting with acute symptomatic basilar thrombosis., Robert D Ecker, Crystiana A Tsujiura, Christopher B Baker, and Deborah Cushing

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Endovascular treatment of massive and submassive pulmonary embolism., Ethan Dobrow and Paul Kim

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Find your element., Robert C Groom

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Invited commentary., Robert S Kramer

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Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines., Joshua C Anderson, Christine W Duarte, Karim Welaya, Timothy D Rohrbach, Markus Bredel, Eddy S Yang, Nirmal V Choradia, Jaideep V Thottassery, George Yancey Gillespie, James A Bonner, and Christopher D Willey

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Mothers' Intentions to Breastfeed and Hospital Practices on Breastfeeding: A Longitudinal Study at 6 Months After Birth on Predictors of Breastfeeding in a Cohort of Mothers From a Large Northern New England Medical Center., Kara L. Kaikini and Kristiina Hykäs

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Navigating Prostate Cancer Screening in the Real World of Primary Care: The Mirage and the Quicksand., Paul Mathew, Hilal Hachem, and Paul Han

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Parasitism of mustelids by ixodid ticks (Acari: Ixodidae), Maine and New Hampshire, U.S.A., Charles Lubelczyk, Eleanor H Lacombe, Susan P Elias, Lorenza Beati, Peter W Rand, and Robert P Smith

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Perioperative management with antiplatelet and statin medication is associated with reduced mortality following vascular surgery., Randall R De Martino, Jens Eldrup-Jorgensen, Brian W Nolan, David H Stone, Julie Adams, Daniel J Bertges, Jack L Cronenwett, and Philip P Goodney

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Prenatal imaging and postnatal presentation, diagnosis and management of congenital lung malformations., James Wall and Anne Coates

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Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis., Nada S Al-Qadheeb, Ethan M Balk, Gilles L Fraser, Yoanna Skrobik, Richard R Riker, John P Kress, Shawn Whitehead, and John W Devlin

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The Development and Implementation of an Obstetrical Triage Tool to Prioritize Patients and Track Process Times by Risk Categories., Devdra Griffin and Kristiina Hyrkas

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Two- and three-dimensional prenatal sonographic diagnosis of Alagille syndrome., Joseph R Wax, Renée Chard, Michael G Pinette, and Angelina Cartin

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Bioenergetics during calvarial osteoblast differentiation reflect strain differences in bone mass., Anyonya R Guntur, Phuong T Le, Charles R Farber, and Clifford J Rosen

Comparison of a pediatric-specific and an institution-wide antibiogram, istina Smith, Jonathan Bourque, and Renee Fallon

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Effects of growth hormone administration for 6 months on bone turnover and bone marrow fat in obese premenopausal women., Miriam A Bredella, Anu V Gerweck, Lauren A Barber, Anne Breggia, Clifford J Rosen, Martin Torriani, and Karen K Miller

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Glycerol phenylbutyrate treatment in children with urea cycle disorders: pooled analysis of short and long-term ammonia control and outcomes., Susan A Berry, Uta Lichter-Konecki, George A Diaz, Shawn E McCandless, William Rhead, Wendy Smith, Cynthia Lemons, Sandesh C S Nagamani, Dion F Coakley, Masoud Mokhtarani, Bruce F Scharschmidt, and Brendan Lee

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Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis., Alex H Gifford, Diana M Alexandru, Zhigang Li, Dana B Dorman, Lisa A Moulton, Katherine E Price, Thomas H Hampton, Mitchell L Sogin, Jonathan B Zuckerman, H Worth Parker, Bruce A Stanton, and George A O'Toole

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Reconsidering against medical advice discharges., Daniel A Meyer

The changing face of America's children: A look at global child mental health., Julia C. Fritz

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The Initiative on Subspecialty Clinical Training and Certification (SCTC): Background and Recommendations., David K. Stevenson, Gail A. McGuinness, John D. Bancroft, Debra M. Boyer, Alan R. Cohen, Joseph T. Gilhooly, Mary Fran Zazinski, Eric S. Holmboe, M. Douglas Jones Jr, Marshall L. Land Jr, Sarah S. Long, Victoria F. Norwood, Daniel J. Schumacher, Theodore C. Sectish, Joseph W. St. Geme III, and Daniel C. West

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The results of a 2-year randomized trial of a worksite weight management intervention., Andrew E Williams, Victor J Stevens, Cheryl L Albright, Claudio R Nigg, Richard T Meenan, and Thomas M Vogt

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Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation., Ashleigh Poole, Nicholas Knowland, Emily Cooper, Rebecca Cole, Hongchuan Wang, Lucas Booth, Doreen Kacer, Francesca Tarantini, Robert Friesel, and Igor Prudovsky

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Trajectories of perceived benefits in living kidney donors: association with donor characteristics and recipient outcomes., James R Rodrigue, Matthew Paek, James Whiting, John Vella, Krista Garrison, Martha Pavlakis, and Didier A Mandelbrot

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Acceptability of telemedicine and other cancer genetic counseling models of service delivery in geographically remote settings., Eileen McDonald, Amanda Lamb, Barbara Grillo, Lee Lucas, and Susan Miesfeldt

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A comparison of usual care, a patient-centred education intervention and motivational interviewing to improve medication adherence and readmissions of adults in an acute-care setting., Kristiina Hyrkas and Marjorie Wiggins

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Bone morphogenetic protein signaling in nephron progenitor cells., Leif Oxburgh, Aaron C. Brown, Sree Deepthi Muthukrishnan, and Jennifer L. Fetting

Clinical Assessment of Dysexecutive Syndromes., John J. Campbell III and Annya Tisher

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Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia., Amanda J Favreau, Calvin P H Vary, Peter C Brooks, and Pradeep Sathyanarayana

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Perceived ambiguity, fatalism, and believing cancer is more prevalent than heart disease., William M P Klein, Rebecca A Ferrer, Kaitlin A Graff, Annette R Kaufman, and Paul K J Han

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Peripheral brain derived neurotrophic factor (BDNF) in bulimia nervosa: a systematic review., Kathryn Phillips, Kathleen Keane, and Barbara E Wolfe

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Physician shadowing by college students: what do patients think?, Robert G Bing-You, Victoria M Hayes, and Jennifer L Skolfield

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Delayed topical p38 MAPK inhibition attenuates full-thickness burn wound inflammatory signaling., Damien Carter, Adelaide Warsen, Katherine Mandell, Joseph Cuschieri, Ronald V Maier, and Saman Arbabi

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Editorial: Predicting surgical satisfaction using artificial neural networks., Anand I Rughani, Travis M Dumont, and Bruce I Tranmer

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Invited commentary., Robert S Kramer and Jeremiah R Brown

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miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia., Melanie L Ufkin, Sarah Peterson, Xuehui Yang, Heather Driscoll, Christine Duarte, and Pradeep Sathyanarayana

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Neointimal patterns obtained by optical coherence tomography correlate with specific histological components and neointimal proliferation in a swine model of restenosis., Jung-Sun Kim, Maxwell E Afari, Jinyong Ha, Armando Tellez, Krzysztof Milewski, Gerard Conditt, Yanping Cheng, Geng Hua Yi, Greg L Kaluza, and Juan F Granada

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Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors., Jijun Hao, Cristi L Galindo, Truc-Linh Tran, and Douglas B Sawyer

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Neuregulin as a heart failure therapy and mediator of reverse remodeling., Cristi L Galindo, Sergey Ryzhov, and Douglas B Sawyer

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Older women's willingness to discontinue Papanicolaou test screening., Ann Skelton, Celine Kuhn, Debra Rothenberg, and Alison Pope

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Use of transesophageal echocardiography to avoid a never event., Paul Lennon, Douglas Salvador, Reed Quinn, and Kathleen Black

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Analysis of intracorporeal compared with extracorporeal urinary diversion after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium., Kamran Ahmed, Shahid A Khan, Matthew H Hayn, Piyush K Agarwal, Ketan K Badani, M Derya Balbay, Erik P Castle, Prokar Dasgupta, Reza Ghavamian, Khurshid A Guru, Ashok K Hemal, Brent K Hollenbeck, Adam S Kibel, Mani Menon, Alex Mottrie, Kenneth Nepple, John G Pattaras, James O Peabody, Vassilis Poulakis, Raj S Pruthi, Joan Palou Redorta, Koon-Ho Rha, Lee Richstone, Matthias Saar, Douglas S Scherr, Stefan Siemer, Michael Stoeckle, Eric M Wallen, Alon Z Weizer, Peter Wiklund, Timothy Wilson, Michael Woods, and Muhammad Shamim Khan

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Developing, evaluating and validating a scoring rubric for written case reports., Peggy R Cyr, Kahsi A Smith, India L Broyles, and Christina T Holt

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Geriatric experience following cardiac arrest at six interventional cardiology centers in the United States 2006-2011: interplay of age, do-not-resuscitate order, and outcomes., David B Seder, Nainesh Patel, John McPherson, Paul McMullan, Karl B Kern, Barbara Unger, Sudip Nanda, Melkon Hacobian, Michael B Kelley, Niklas Nielsen, John Dziodzio, and Michael Mooney

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Is there a place for medical students as teachers in the education of junior residents?, Keith Wirth, Bethany Malone, Kaylene Barrera, Warren D Widmann, Christopher Turner, and Aliu Sanni

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Modifiable risk factors associated with tuberculosis disease in children in Pune, India., J Jubulis, A Kinikar, M Ithape, M Khandave, S Dixit, S Hotalkar, V Kulkarni, V Mave, N Gupte, A Kagal, S Jain, R Bharadwaj, and A Gupta

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Phenylalanine hydroxylase deficiency: diagnosis and management guideline., Jerry Vockley, Hans C Andersson, Kevin M Antshel, Nancy E Braverman, Barbara K Burton, Dianne M Frazier, John Mitchell, Wendy E Smith, Barry H Thompson, and Susan A Berry

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Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis., Xiang Hua Han, Yong-Ri Jin, Leonard Tan, Tatiana Kosciuk, Jin-Seon Lee, and Jeong Kyo Yoon

Resveratrol: Highlights of Relatively Recent Interest in an Old Chemical., Ted Wissink and Matt Stevens

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Thirty U.S. Poison Center reports later: greater demand, more difficult problems., K E Simone

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Pediatric refugees in Rhode Island: increases in BMI percentile, overweight, and obesity following resettlement., Jessica H Heney, Camia C Dimock, Jennifer F Friedman, and Carol Lewis

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Driving policy after seizures and unexplained syncope: a practice guide for RI physicians., Maxwell E Afari, Andrew S Blum, Stephen T Mernoff, and Brian R Ott

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Adrenal insufficiency in a woman secondary to standard-dose inhaled fluticasone propionate therapy., Casey M Hay and Daniel I Spratt

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Advances in therapy for pediatric sarcomas., Aaron Weiss, Jonathan Gill, John Goldberg, Joanne Lagmay, Holly Spraker-Perlman, Rajkumar Venkatramani, and Damon Reed

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A matter of balance: older adults taking control of falls by building confidence., Margaret Haynes, Patricia League, and Gloria Neault

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An argument for comprehensiveness as the "special sauce" in a recipe for the patient-centered medical home., Christina Holt

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Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial., Daniel M Pearlman, Jeremiah R Brown, Todd A MacKenzie, Felix Hernandez, and Souhel Najjar

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Breast cancer knowledge, beliefs, and screening practices among women seeking care at district hospitals in Dar es Salaam, Tanzania., Emma Perry Morse, Bertha Maegga, Gertrud Joseph, and Susan Miesfeldt

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Chapter: Practice in a rural setting., Robert J. Ferguson, Amber Ferguson, Jeff Matranga, and Sandra Sigmon

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Chapter: Systems development of behavioral health in primary care., Julie Schirmer and Jeffery F. Markuns

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Common features of microRNA target prediction tools., Sarah M Peterson, Jeffrey A Thompson, Melanie L Ufkin, Pradeep Sathyanarayana, Lucy Liaw, and Clare Bates Congdon

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Communication of suicidality via social media., Erin L. Belfort

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Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity., Qing He, Xuehui Yang, Yan Gong, Dmitry Kovalenko, Ernesto Canalis, Clifford J Rosen, and Robert E Friesel