Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2014

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Neuregulin as a heart failure therapy and mediator of reverse remodeling., Cristi L Galindo, Sergey Ryzhov, and Douglas B Sawyer

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Older women's willingness to discontinue Papanicolaou test screening., Ann Skelton, Celine Kuhn, Debra Rothenberg, and Alison Pope

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Use of transesophageal echocardiography to avoid a never event., Paul Lennon, Douglas Salvador, Reed Quinn, and Kathleen Black

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Analysis of intracorporeal compared with extracorporeal urinary diversion after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium., Kamran Ahmed, Shahid A Khan, Matthew H Hayn, Piyush K Agarwal, Ketan K Badani, M Derya Balbay, Erik P Castle, Prokar Dasgupta, Reza Ghavamian, Khurshid A Guru, Ashok K Hemal, Brent K Hollenbeck, Adam S Kibel, Mani Menon, Alex Mottrie, Kenneth Nepple, John G Pattaras, James O Peabody, Vassilis Poulakis, Raj S Pruthi, Joan Palou Redorta, Koon-Ho Rha, Lee Richstone, Matthias Saar, Douglas S Scherr, Stefan Siemer, Michael Stoeckle, Eric M Wallen, Alon Z Weizer, Peter Wiklund, Timothy Wilson, Michael Woods, and Muhammad Shamim Khan

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Developing, evaluating and validating a scoring rubric for written case reports., Peggy R Cyr, Kahsi A Smith, India L Broyles, and Christina T Holt

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Geriatric experience following cardiac arrest at six interventional cardiology centers in the United States 2006-2011: interplay of age, do-not-resuscitate order, and outcomes., David B Seder, Nainesh Patel, John McPherson, Paul McMullan, Karl B Kern, Barbara Unger, Sudip Nanda, Melkon Hacobian, Michael B Kelley, Niklas Nielsen, John Dziodzio, and Michael Mooney

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Is there a place for medical students as teachers in the education of junior residents?, Keith Wirth, Bethany Malone, Kaylene Barrera, Warren D Widmann, Christopher Turner, and Aliu Sanni

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Modifiable risk factors associated with tuberculosis disease in children in Pune, India., J Jubulis, A Kinikar, M Ithape, M Khandave, S Dixit, S Hotalkar, V Kulkarni, V Mave, N Gupte, A Kagal, S Jain, R Bharadwaj, and A Gupta

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Phenylalanine hydroxylase deficiency: diagnosis and management guideline., Jerry Vockley, Hans C Andersson, Kevin M Antshel, Nancy E Braverman, Barbara K Burton, Dianne M Frazier, John Mitchell, Wendy E Smith, Barry H Thompson, and Susan A Berry

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Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis., Xiang Hua Han, Yong-Ri Jin, Leonard Tan, Tatiana Kosciuk, Jin-Seon Lee, and Jeong Kyo Yoon

Resveratrol: Highlights of Relatively Recent Interest in an Old Chemical., Ted Wissink and Matt Stevens

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Thirty U.S. Poison Center reports later: greater demand, more difficult problems., K E Simone

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Methods For Treating Metabolic Syndrome With Cthrc1 Polypeptide, Volkhard Lindner and Maine Medical Center

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Pediatric refugees in Rhode Island: increases in BMI percentile, overweight, and obesity following resettlement., Jessica H Heney, Camia C Dimock, Jennifer F Friedman, and Carol Lewis

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Driving policy after seizures and unexplained syncope: a practice guide for RI physicians., Maxwell E Afari, Andrew S Blum, Stephen T Mernoff, and Brian R Ott

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Adrenal insufficiency in a woman secondary to standard-dose inhaled fluticasone propionate therapy., Casey M Hay and Daniel I Spratt

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Advances in therapy for pediatric sarcomas., Aaron Weiss, Jonathan Gill, John Goldberg, Joanne Lagmay, Holly Spraker-Perlman, Rajkumar Venkatramani, and Damon Reed

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A matter of balance: older adults taking control of falls by building confidence., Margaret Haynes, Patricia League, and Gloria Neault

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An argument for comprehensiveness as the "special sauce" in a recipe for the patient-centered medical home., Christina Holt

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Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial., Daniel M Pearlman, Jeremiah R Brown, Todd A MacKenzie, Felix Hernandez, and Souhel Najjar

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Breast cancer knowledge, beliefs, and screening practices among women seeking care at district hospitals in Dar es Salaam, Tanzania., Emma Perry Morse, Bertha Maegga, Gertrud Joseph, and Susan Miesfeldt

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Chapter: Practice in a rural setting., Robert J. Ferguson, Amber Ferguson, Jeff Matranga, and Sandra Sigmon

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Chapter: Systems development of behavioral health in primary care., Julie Schirmer and Jeffery F. Markuns

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Common features of microRNA target prediction tools., Sarah M Peterson, Jeffrey A Thompson, Melanie L Ufkin, Pradeep Sathyanarayana, Lucy Liaw, and Clare Bates Congdon

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Communication of suicidality via social media., Erin L. Belfort

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Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity., Qing He, Xuehui Yang, Yan Gong, Dmitry Kovalenko, Ernesto Canalis, Clifford J Rosen, and Robert E Friesel

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Detection of eastern equine encephalitis virus antibodies in moose (Alces americana), Maine, 2010., Charles Lubelczyk, Susan P Elias, Lee Kantar, Jennifer Albert, Stephen Hansen, Kali Saxton-Shaw, Katharine MacMillan, Leticia B Smith, Rebecca Eisen, Bethany Swope, Robert Pease Smith, and John-Paul Mutebi

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Development and evaluation of a risk communication curriculum for medical students., Paul K J Han, Katherine Joekes, Glyn Elwyn, Kathleen M Mazor, Richard Thomson, Philip Sedgwick, Judith Ibison, and John B Wong

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Early cardiac catheterization is associated with improved survival in comatose survivors of cardiac arrest without STEMI., Ryan D Hollenbeck, John A McPherson, Michael R Mooney, Barbara T Unger, Nainesh C Patel, Paul W McMullan, Chiu-Hsieh Hsu, David B Seder, and Karl B Kern

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Effect of a dedicated acute care operating room on hospital efficiency., Cecilia Trydestam, Steven Prato, Brad Cushing, and James Whiting

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Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors., Christine W Duarte, J Patrizia Stohn, Qiaozeng Wang, Ivette F Emery, Andrew Prueser, and Volkhard Lindner

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Evidence-based leadership council - a national collaborative., Margaret Haynes, Susan Hughes, Kate Lorig, June Simmons, Susan J Snyder, Lesley Steinman, Nancy Wilson, Roseanne DiStefano, Jennifer Raymond, Stephanie FallCreek, Martha B Pelaez, and Don Smith

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Factors associated with different patterns of nonadherence to HIV care in Dar es Salaam, Tanzania., Gabriela Poles, Michelle Li, Hellen Siril, Aisa Mhalu, Claudia Hawkins, Sylvia Kaaya, Eric Aris, Guerino Chalamilla, and Lisa R Hirschhorn

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FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney., Jennifer L Fetting, Justin A Guay, Michele J Karolak, Renato V Iozzo, Derek C Adams, David E Maridas, Aaron C Brown, and Leif Oxburgh

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Home diuretic protocol for heart failure: partnering with home health to improve outcomes and reduce readmissions., Richard P Veilleux, Joseph N Wight, Ann Cannon, Moira Whalen, and David Bachman

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Impact of perioperative acute kidney injury as a severity index for thirty-day readmission after cardiac surgery., Jeremiah R Brown, Chirag R Parikh, Cathy S Ross, Robert S Kramer, Patrick C Magnus, Kristine Chaisson, Richard A Boss, Robert E Helm, Susan R Horton, Patricia Hofmaster, Helen Desaulniers, Pamela Blajda, Benjamin M Westbrook, Dennis Duquette, Kelly LeBlond, Reed D Quinn, Cheryl Jones, Anthony W DiScipio, and David J Malenka

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Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia., Christine W Duarte, Kimberly Murray, F Lee Lucas, Kathleen Fairfield, Heather Miller, Peter Brooks, and Calvin P H Vary

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Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with Wiskott-Aldrich syndrome., Amy E O'Connell, Stefano Volpi, Kerry Dobbs, Claudia Fiorini, Erdyni Tsitsikov, Helen de Boer, Isil B Barlan, Jenny M Despotovic, Francisco J Espinosa-Rosales, I Celine Hanson, Maria G Kanariou, Roxana Martínez-Beckerat, Alvaro Mayorga-Sirera, Carmen Mejia-Carvajal, Nesrine Radwan, Aaron R Weiss, Sung-Yun Pai, Yu Nee Lee, and Luigi D Notarangelo

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Overview of genetic tools and techniques to study Notch signaling in mice., Thomas Gridley and Andrew K Groves

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Partnership, Maine Medical Center

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Psychiatric hospital treatment of children with autism and serious behavioral disturbance., Matthew Siegel and Robin L Gabriels

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Relationship between regional spending on vascular care and amputation rate., Philip P Goodney, Lori L Travis, Benjamin S Brooke, Randall R DeMartino, David C Goodman, Elliott S Fisher, and John D Birkmeyer

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The epidemiology and pathogenesis of osteoporosis., Clifford J. Rosen

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The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life., Mark A Zander, Gonzalo I Cancino, Thomas Gridley, David R Kaplan, and Freda D Miller

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Total knee arthroplasty designed to accommodate the presence or absence of the posterior cruciate ligament., Melinda K Harman, Stephanie J Bonin, Chris J Leslie, Scott A Banks, and W Andrew Hodge

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Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction., Ting Wang, Linden A Green, Samir K Gupta, Chul Kim, Liang Wang, Sharilyn Almodovar, Sonia C Flores, Igor A Prudovsky, Paul Jolicoeur, Ziyue Liu, and Matthias Clauss

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Unfreezing the Flexnerian Model: introducing longitudinal integrated clerkships in rural communities., Robert G Bing-You, Robert L Trowbridge, Catherine Kruithoff, and John L Daggett

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Use of osmium tetroxide staining with microcomputerized tomography to visualize and quantify bone marrow adipose tissue in vivo., Erica L Scheller, Nancy Troiano, Joshua N Vanhoutan, Mary A Bouxsein, Jackie A Fretz, Yougen Xi, Tracy Nelson, Griffin Katz, Ryan Berry, Christopher D Church, Matthew S Rodeheffer, Ormond A Macdougald, Clifford J Rosen, Mark C Horowitz, and Casey R. Doucette

Submissions from 2013

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Impairment of subendocardial perfusion reserve and oxidative metabolism in nonischemic dilated cardiomyopathy., Susan P Bell, Douglas W Adkisson, Henry Ooi, Douglas B Sawyer, Mark A Lawson, and Marvin W Kronenberg

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Radical, passionate, and curious., Robert C Groom

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Validity and reliability of the critical care pain observation tool: a replication study., Kathleen Marie Keane

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Vitamin D and calcium: what do we need to know?, Vincent Zhang, Xuezhi Jiang, Yousaf Z Farukhi, Clifford J Rosen, and Peter F Schnatz

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Absence of a major role for the snai1 and snai3 genes in regulating skeletal muscle regeneration in mice., Christine R Norton, Ying Chen, Xiang Hua Han, Cara K Bradley, Luke T Krebs, Jeong Kyo Yoon, and Thomas Gridley

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Know Thyself: A Knowledge Repository in the Hospital Setting, Dina McKelvy

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Contemporary issues in nursing: patient safety, decision-making and social support in challenging economic times., Lynn Macken and Kristiina Hyrkas

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Estimating the effect of emergency care on early survival after traffic crashes., David E Clark, Robert J Winchell, and Rebecca A Betensky

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Risk modifiers for concussion and prolonged recovery., Kristen A Scopaz and John R Hatzenbuehler

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Testing the reliability of the Fall Risk Screening Tool in an elderly ambulatory population., Susan J Fielding, Michael McKay, and Kristiina Hyrkas

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The effect of medical students and residents on measures of efficiency and timeliness in an academic medical center emergency department., Matthew DeLaney, Kate D Zimmerman, Tania D Strout, and Megan L Fix

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Interactive 3D analysis of blood vessel trees and collateral vessel volumes in magnetic resonance angiograms in the mouse ischemic hindlimb model., Peter C Marks, Marilena Preda, Terry Henderson, Lucy Liaw, Volkhard Lindner, Robert E Friesel, and Ilka M Pinz

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IGF-1 regulation of key signaling pathways in bone., Anyonya R Guntur and Clifford J Rosen

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Acute complications of movement disorders surgery: effects of age and comorbidities., Anand I Rughani, Mojgan Hodaie, and Andres M Lozano

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Dietary calcium from dairy and nondairy sources, and risk of symptomatic kidney stones., Eric N Taylor and Gary C Curhan

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Educational agenda for diagnostic error reduction., Robert L Trowbridge, Gurpreet Dhaliwal, and Karen S Cosby

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Impact of Let's Go! 5-2-1-0: a community-based, multisetting childhood obesity prevention program., Victoria W Rogers, Patricia H Hart, Elizabeth Motyka, Emily N Rines, Jackie Vine, and Deborah A Deatrick

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Sex-specific association of a common variant of the XG gene with autism spectrum disorders., Shun-Chiao Chang, David L Pauls, Christoph Lange, Roksana Sasanfar, and Susan L Santangelo

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Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src., Yan Gong, Xuehui Yang, Qing He, Lindsey Gower, Igor Prudovsky, Calvin P H Vary, Peter C Brooks, and Robert E Friesel

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TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells., Thomas Green, Xiaofei Chen, Stephen Ryan, Adam S Asch, and Maria J Ruiz-Echevarría

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Telephone administration of the aberrant behavior checklist: a pilot study of feasibility in children with intellectual disability and autism., Matthew Siegel, Briana Milligan, Hannah Stein, Olivia Teer, and Kahsi A Smith

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The value of personalised risk information: a qualitative study of the perceptions of patients with prostate cancer., Paul K J Han, Norbert Hootsmans, Michael Neilson, Bethany Roy, Terence Kungel, Caitlin Gutheil, Michael Diefenbach, and Moritz Hansen

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Patient safety in the cardiac operating room: human factors and teamwork: a scientific statement from the American Heart Association., Joyce A Wahr, Richard L Prager, J H Abernathy, Elizabeth A Martinez, Eduardo Salas, Patricia C Seifert, Robert C Groom, Bruce D Spiess, Bruce E Searles, Thoralf M Sundt, Juan A Sanchez, Scott A Shappell, Michael H Culig, Elizabeth H Lazzara, David C Fitzgerald, Vinod H Thourani, Pirooz Eghtesady, John S Ikonomidis, Michael R England, Frank W Sellke, Nancy A Nussmeier, and American Heart Association Council on Cardiovascular on Quality of Care and Outcomes Research

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Altered thermogenesis and impaired bone remodeling in Misty mice., Katherine J Motyl, Kathleen A Bishop, Victoria E DeMambro, Sheila A Bornstein, Phuong Le, Masanobu Kawai, Sutada Lotinun, Mark C Horowitz, Roland Baron, Mary L Bouxsein, and Clifford J Rosen

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Mediastinal teratoma diagnosed via ultrasound-guided biopsy., Elena L Resnick, Jennifer M Talmadge, and Steven S Winn

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Test- Management of the base of the appendix in pediatric laparoscopic appendectomy: clip, ligate, or staple?, Monica Langer, Arash Safavi, and Erik D Skarsgard

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The path to best care., Robert C Groom

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Stent healing response following delivery of paclitaxel via durable polymeric matrix versus iopromide-based balloon coating in the familial hypercholesterolaemic swine model of coronary injury., Piotr P Buszman, Armando Tellez, Maxwell Afari, Yanping Cheng, Gerard B Conditt, Jennifer C McGregor, Krzysztof Milewski, Mark Stenoien, Greg L Kaluza, and Juan F Granada

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Effect of chronic oral anticoagulation with warfarin on the durability and outcomes of endovascular aortic aneurysm repair., Marques S Johnson, Jasmine Chiang, Jens Eldrup-Jorgensen, David E Clark, and Christopher T Healey

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Lesser trochanter avulsion fracture., Nicholas C Papacostas, Christopher T Bowe, and Tania D Shaffer Strout

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Tissue uptake, distribution, and healing response after delivery of paclitaxel via second-generation iopromide-based balloon coating: a comparison with the first-generation technology in the iliofemoral porcine model., Piotr P Buszman, Armando Tellez, Maxwell E Afari, Athanasios Peppas, Gerard B Conditt, Serge D Rousselle, Jennifer C McGregor, Mark Stenoien, Greg L Kaluza, and Juan F Granada

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Common misconceptions about vitamin D--implications for clinicians., Clifford J Rosen and Christine L Taylor

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National evidence on the use of shared decision making in prostate-specific antigen screening., Paul K J Han, Sarah Kobrin, Nancy Breen, Djenaba A Joseph, Jun Li, Dominick L Frosch, and Carrie N Klabunde

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Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis., Fabienne L Gray, Christopher G Turner, David Zurakowski, Athos Bousvaros, Bradley C Linden, Robert C Shamberger, and Craig W Lillehei

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SPECT vs CT: CT is not the first line test for the diagnosis and prognosis of stable coronary artery disease., Zachary J Trzaska and Mylan C Cohen

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The SNAI1 and SNAI2 proteins occupy their own and each other's promoter during chondrogenesis., Ying Chen and Thomas Gridley

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Carotid artery endarterectomy: a multidisciplinary approach to improving resource utilization and quality assurance., Jill A Knutson, Carol Jo Morse, Jens Eldrup-Jorgensen, Margaret Estee, Lois Hayworth, Tara A Herman, and Angela S Vereshko

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Closure of tubular patent ductus arteriosus in infants with the Amplatzer Vascular Plug II., Abby A R Gross and Jon P Donnelly

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Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis., Ying Chen and Thomas Gridley

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Pediatric postoperative intussusception in the minimally invasive surgery era: a 13-year, single center experience., Justin D Klein, Christopher G Turner, Sophia C Kamran, Alvin Y C Yu, Lynne Ferrari, David Zurakowski, and Dario O Fauza

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Combating infections at Maine Medical Center: Insights into complexity-informed leadership from positive deviance, Curt Lindberg and Margaritte Schneider

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HELP© prevent falls by preventing delirium., Rhonda L Babine, Stacey Farrington, and Heidi R Wierman

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Historic condition in a modern child with autism., Megan Berube, Carol Hubbard, Leah Mallory, Eric Larsen, Peter Morrison, and Marilyn Augustyn

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Managing blunt trauma in patients receiving dabigatran etexilate: case study and review of the literature., Peter Eamonn Croft, Katherine P Cabral, Tania D Strout, Michael R Baumann, Michael A Gibbs, and Matthew C Delaney

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Periurethral aggressive angiomyxoma: a case report., Caroline Foust-Wright, Arielle Allen, and S Abbas Shobeiri

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Aorto-mesenteric and renal allograft transplant: a novel treatment for midaortic syndrome., K Vakili, N M Fullington, C G Turner, R P Cauley, K M Potanos, S Lee, M Ferguson, J E Lock, and H B Kim

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Congenital hypothyroidism., Heather J Shanholtz

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ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions., Laura Pentassuglia and Douglas B Sawyer

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Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis., Yuefeng Tang, Hao Bai, Sumithra Urs, Zack Wang, and Lucy Liaw

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Physicians' beliefs about breast cancer surveillance testing are consistent with test overuse., Paul K J Han, Carrie N Klabunde, Anne-Michelle Noone, Craig C Earle, John Z Ayanian, Patricia A Ganz, Katherine S Virgo, and Arnold L Potosky

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Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1β/ErbB in response to myocardial infarction resulting in worsening heart failure., Oghenerukevwe Odiete, Ewa A Konik, Douglas B Sawyer, and Michael F Hill

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Role for compartmentalization in nephron progenitor differentiation., Aaron C Brown, Sree Deepthi Muthukrishnan, Justin A Guay, Derek C Adams, Dillon A Schafer, Jennifer L Fetting, and Leif Oxburgh